Results 21 to 30 of about 405 (144)
mBio, 2022 β-Lactamases hydrolyze β-lactam antibiotics and are major determinants of antibiotic resistance in Gram-negative pathogens. Enmetazobactam (formerly AAI101) and tazobactam are penicillanic acid sulfone (PAS) β-lactamase inhibitors that differ by an ...
Philip Hinchliffe +10 more
doaj +1 more source
Journal of Global Antimicrobial Resistance, 2021 : Objectives: This study aimed to investigate third-generation cephalosporin (3GC) resistance determinants [extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases and OXA-type β-lactamases] in contemporary clinical Enterobacterales isolates and to ...
Adam Belley +4 more
doaj +1 more source
Safety evaluation of current therapies for high-risk severely ill patients with carbapenem-resistant infections [PDF]
, 2021 Introduction Infections due to carbapenem-resistant Gram-negative bacteria (CR-GNB) are increasingly frequent events, which are associated with a high mortality rate.
Bassetti, Matteo +4 more
core +1 more source
Biochemical exploration of β-lactamase inhibitors [PDF]
, 2023 The alarming rise of microbial resistance to antibiotics has severely limited the efficacy of current treatment options. The prevalence of β-lactamase enzymes is a significant contributor to the emergence of antibiotic resistance.
Debasish Kar, Varshaa Arer
core +1 more source
Iranian Journal of Microbiology, 2022 Background and Objectives: Escherichia coli (E. coli) is an important member of Enterobacteriaceae family involved in severe infections. The increased rate of resistance towards different classes of antibiotics limits their treatment options. The aim of
Ashraf Ahmed Kadry +2 more
doaj +1 more source
Liquid chromatography–tandem mass spectrometry for the simultaneous quantitation of enmetazobactam and cefepime in human plasma [PDF]
Journal of Pharmaceutical and Biomedical Analysis, 2019 A simple ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the simultaneous analysis enmetazobactam (also known as AAI101) and cefepime in human plasma. Sample preparation was based on protein precipitation with acetonitrile. Separation was performed on Acquity BEH HILIC column (50 mm ×
M, Mameli +7 more
+11 more sources
Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors
Proceedings of the National Academy of Sciences, 2022 SignificanceMicrobial resistance to β-lactam antibiotics mediated by β-lactamase–catalyzed hydrolysis is a major global health concern. Penam sulfones, which are structurally related to penicillins, inhibit clinically important serine β-lactamases (SBLs) by forming transiently stable covalent complexes, thereby protecting β-lactam antibiotics from ...
Lang, PA +7 more
openaire +3 more sources
Recommendations to Synthetize Old and New β-Lactamases Inhibitors: A Review to Encourage Further Production [PDF]
, 2022 open2The increasing emergence of bacteria producing β-lactamases enzymes (BLEs), able to inactivate the available β-lactam antibiotics (BLAs), causing the hydrolytic opening of their β-lactam ring, is one of the global major warnings.
Alfei, Silvana, Zuccari, Guendalina
core +1 more source
Cefepime/Enmetazobactam. [PDF]
Hosp PharmEach month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing
Staten AR, Baker DE.
europepmc +3 more sources
Antimicrobial resistance conferred by OXA-48 β-lactamases:towards a detailed mechanistic understanding [PDF]
, 2021 OXA-48-type β-lactamases are now routinely encountered in bacterial infections caused by carbapenem-resistant Enterobacterales. These enzymes are of high and growing clinical significance due to the importance of carbapenems in treatment of health care ...
Hirvonen, Viivi H A +2 more
core +2 more sources