Results 101 to 110 of about 43,584 (222)

Development and Validation of a Predictive Nomogram for Diagnosing Colorectal Cancer Based on Immune‐Nutritional Score

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Early diagnosis of colorectal cancer (CRC) can significantly improve prognosis, but currently there is a lack of simple and effective screening methods in clinical practice. Methods This single‐center retrospective study included patients with CRC and benign colorectal polyps (BCP) diagnosed at our hospital between December 2020 and
Xiaofan Liu, Liuqun Shan, Wei Liang, Lin Fu, Rong Wu, Linzhu Zhang, Qian Lv, Wei Shi, Fei Fei   +8 more
wiley   +1 more source

Melatonin Enhances Heat Tolerance via Increasing Antioxidant Enzyme Activities and Osmotic Regulatory Substances by Upregulating zmeno1 Expression in Maize (Zea mays L.)

Antioxidants
Heat stress severely affects the yield and quality of maize. Melatonin (N-acetyl-5-methoxy-tryptamin, MT) plays an important role in various types of stress resistance in plants, including heat tolerance.
Liru Cao, Abbas Muhammad Fahim, Xiaohan Liang, Senmiao Fan, Yinghui Song, Huafeng Liu, Feiyu Ye, Chenchen Ma, Dongling Zhang, Xiaomin Lu   +9 more
doaj   +1 more source

What Is Your Diagnosis? Splenic Mass in an African Pygmy Hedgehog

Veterinary Clinical Pathology, EarlyView.
Gabriela Hartmann, Milena Carolina Paz, Paola Sônego, Ana Carolina Contri Natal, Lívia Surita, Marcele Bettim Bandinelli, Luciana Sonne   +6 more
wiley   +1 more source

Critical role of keratinocytes and protease‐activated receptor 2 in secondary lymphedema development

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Activated keratinocytes play an important role in the early stage of the pathophysiology of secondary lymphedema through PAR2 signaling. Lymphatic injury‐induced protease activation stimulates keratinocyte PAR2 signaling, driving hyperkeratosis and Th2 inflammation, which can be therapeutically attenuated by teriflunomide. Abstract Background Secondary
Hyeung Ju Park, Sarit Pal, Xizhao Chen, Jinyeon Shin, Gabriela D. García Nores, Jung Eun Baik, Annica Stull‐Lane, Abraham J. Book, Cristina C. Clement, Elizabeth M. Encarnacion, Mark G. Klang, Elyn Riedel, Tafadzwa L. Chaunzwa, Geoffrey E. Hespe, Laura Santambrogio, Michelle Coriddi, Joseph H. Dayan, Babak J. Mehrara, Raghu P. Kataru   +18 more
wiley   +1 more source

Plasmacytoid Dendritic Cells Exhibit High Transferrin Receptor Expression Without Iron Accumulation

European Journal of Immunology, Volume 56, Issue 6, June 2026.
• pDCs are defined by high surface TFRC expression and dynamic iron flux, distinguishing them from conventional dendritic cell subsets. • In the Iron proteome, pDC are enriched for mitochondrial heme and Fe–S proteins but have similar iron storage to cDC. • Iron chelation does not disrupt pDC type‐1 IFN production. ABSTRACT Plasmacytoid dendritic cells
Carrie Corkish, Simon O'Shaughnessy, Claire Lin, Sophia Wugk, Sarah Kenny, Linda Sinclair, Suzanne Cloonan, David Finlay   +7 more
wiley   +1 more source

Impact of Enolase in Allergic Disease

Current Allergy and Asthma Reports
There is growing evidence that enolase is involved in allergy. This manuscript reviews the impact of enolase in allergic disease and describes several sources of this allergen including molds, plants, animals, and pollens, among others. IgE epitopes are carefully analyzed as they may account for cross-reactivity.Enolase has been previously associated ...
Morales-Amparano, Martha Beatriz, Teran, Maria G, Huerta-Ocampo, José Ángel, Teran, Luis M   +3 more
openaire   +2 more sources

Systemic Inflammation and Central Neuronal Damage: The Relationship Between Neutrophil‐to‐Lymphocyte Ratio and Neuron‐Specific Enolase in Acute Ischemic Stroke

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Background and Purpose The systemic inflammatory response, quantified by the neutrophil‐to‐lymphocyte ratio (NLR), and central neuronal injury, reflected by serum neuron‐specific enolase (NSE), are implicated in the pathogenesis of acute ischemic stroke (AIS).
Ning Rong, Hongyan Li, Siyu Qian, Yiting Ya, Hongfu Tian, Ningning Wang, Yuehua Yu, De‐Sheng Zhu, Min‐Yuan Liu   +8 more
wiley   +1 more source

Dysregulation of Non‐Muscle Myosin IIA Assembly and Phosphorylation in S100A4 Null Mouse Lens

Journal of Cellular Physiology, Volume 241, Issue 6, June 2026.
This study identifies S100A4 as a critical regulator of NMIIA assembly, phosphorylation, and actin cytoskeletal organization in the ocular lens. Loss of S100A4 disrupts lens fiber cell architecture and impairs lens transparency, revealing a previously unrecognized role for S100A4 in maintaining lens homeostasis and structural integrity.
Rupalatha Maddala, Levi K. Lankford, Nikolai P. Skiba, Ponugoti V. Rao   +3 more
wiley   +1 more source

RAGE Re‐Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end‐products (RAGE) is expressed by several cell types and sustains the inflammatory response in acute and chronic diseases. Total ablation of RAGE (Ager−/
Sara Chiappalupi, Giulia Gentili, Laura Salvadori, Martina Paiella, Marcello Manfredi, Vittoria Federica Borrini, Kaamashri Mangar, Ann Marie Schmidt, Maurizio Muscaritoli, Francesca Riuzzi, Guglielmo Sorci   +10 more
wiley   +1 more source

EV‐SPEC: Decoding the Spatial Proteomic Signature of the Extracellular Vesicle Corona

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
This study introduces ‘EV‑SPEC’, a spatial proteomics method using TurboID fused to the transmembrane protein CD63 to map the protein corona of extracellular vesicles (EVs) without physical isolation. We show that EV‐SPEC identifies the protein‐protein interaction footprint of serum proteins, similar to those typically found on synthetic nanoparticles,
Camille Menaceur Vandenbroucke, Carsten Scavenius, Yuya Hayashi   +2 more
wiley   +1 more source