Results 111 to 120 of about 43,806 (240)

The Role of Precision Medicine in Neuroblastoma: Targeted Therapies and Personalized Approaches—A Narrative Review

open access: yesHealth Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Neuroblastoma is the most common extracranial solid tumor and contributes the most to pediatric oncology deaths worldwide. Its clinical manifestations are heterogeneous, including relapses, and the prognosis remains poor, especially for high‐risk patients.
Mosammat Jannatul Mawa   +3 more
wiley   +1 more source

Correction: Exposure of HL-60 human leukaemic cells to 4-hydroxynonenal promotes the formation of adduct(s) with α-enolase devoid of plasminogen binding activity. [PDF]

open access: yesBiochem J
Barrera G   +14 more
europepmc   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao   +4 more
wiley   +1 more source

The relationship of glycerol and glycolysis metabolism patway under hyperosmotic stress in Dunaliella salina

open access: yesOpen Life Sciences, 2014
Xia Bing-Bing   +3 more
doaj   +1 more source

Monitoring the Effect of Tributyltin Salicylate and Propionate, Retinoid X Receptor Ligands, on Heat Shock Protein Expression in MDA‐MB‐231 Cells by MALDI MS/MS

open access: yesJournal of Mass Spectrometry, Volume 61, Issue 8, August 2026.
ABSTRACT Organotin (IV) compounds are known to induce apoptosis via the intrinsic mitochondrial pathway, which is a key mechanism of effective anticancer therapy. Their ability to selectively promote apoptotic cell death highlights their potential as chemotherapeutic agents. In this study, the in vitro effects of two triorganotin compounds, tributyltin
Dana Strouhalova   +3 more
wiley   +1 more source

Targeting the NAT1‐ENO1‐Lactate Axis Destabilizes PD‐L1 to Reinvigorate Antitumor Immunity in Colorectal Cancer

open access: yesMedComm, Volume 7, Issue 8, August 2026.
NAT1 downregulates PD‐L1 protein expression by acetylating ENO1, which inhibits lactate‐fueled TRAF6/PD‐L1 signaling (left). Conversely, NAT1 deficiency in CRC cells enhances ENO1 activation, leading to increased glycolysis and lactate production. The lactate then binds to TRAF6, promoting its oligomerization and activation.
Yi‐Xuan Liu   +18 more
wiley   +1 more source

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