Results 61 to 70 of about 39,529 (215)

Treatment With Valoctocogene Roxaparvovec in a Patient With Severe Hemophilia A Led to Sustained Normal FVIII Levels

Haemophilia, EarlyView.
ABSTRACT Introduction Valoctocogene roxaparvovec, an adeno‐associated virus (AAV)‐based gene therapy, enables endogenous factor VIII (FVIII) expression in patients with severe hemophilia A without the need for regular FVIII infusions. Long‐term follow‐up assesses durability, safety, and immune‐related challenges following gene therapy.
Kerstin Herbst, Behnaz Pezeshkpoor, Claudia Klein, Thilo Albert, Philipp Lutz, Christian Strassburg, Ulrich Spengler, Georg Goldmann, Johannes Oldenburg   +8 more
wiley   +1 more source

Obtaining the Enoxaparin Sodium Substance Equivalent to the Original Clexane® and Lovenox®. The Selection of Technological Parameters and Optimization of the “Greenness” of the Purification Stage

Журнал органічної та фармацевтичної хімії, 2023
The aim of the study was to adjust and optimize the purification stage of crude enoxaparin sodium to obtain a substance equivalent to the original drugs Clexane® and Lovenox® according to the criteria specified by the FDA. The purification stage involves
Yuliia V. Bovsunovska, Vitalii V. Rudiuk, Nataliia V. Harna, Olha S. Holovchenko, Victoriya A. Georgiyants   +4 more
doaj   +1 more source

Perspectives of Healthcare Professionals, Patients and Family Members on Managing Regular Medications Across the Perioperative Pathway: An Exploratory Qualitative Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore healthcare professionals', patients', and family members' experiences of managing regular medications across the perioperative pathway in a specialist cancer hospital in Melbourne. Design An exploratory qualitative study using a descriptive‐interpretive approach.
Atefeh Mehrabifar, Elizabeth Manias, Thomas E. Poulton, Bernhard Riedel, Janelle Penno, Patricia Nicholson   +5 more
wiley   +1 more source

Spontaneous uterine rupture after myomectomy in patients during pregnancy: Clinical cases in a single university center

International Journal of Gynecology &Obstetrics, Volume 173, Issue 1, Page 24-34, April 2026.
Abstract Uterine rupture is an infrequent yet sometimes fatal complication of a subsequent vaginal birth attempt following a previous uterine surgery. We have chosen to write about spontaneous uterine ruptures following myomectomy due to the scarcity of data on this subject, stemming from the limited number of reported cases.
Alessandra Brenta, Elena Cesari, Susanna Bonato, Valeria Maria Savasi   +3 more
wiley   +1 more source

Contrast-enhanced Computed Tomography Screening Is Effective for Detecting Venous Thromboembolism not Prevented by Prophylaxis after Total Knee Arthroplasty [PDF]

, 2015
Venous thromboembolism (VTE) is a potential complication occurring after total knee arthroplasty (TKA). We investigated the incidence of VTE after TKA using contrast-enhanced computed tomography (CT), and assessed the efficacy of VTE prophylaxis ...
Abe, Nobuhiro, Fujii, Masataka, Furumatsu, Takayuki, Miyazawa, Shinichi, Okada, Yukimasa, Ozaki, Toshifumi, Tanaka, Takaaki   +6 more
core   +1 more source

At the core of the interaction: Probing charged side chains in flexible protein regions with simultaneous nuclear magnetic resonance experiments

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Charged amino acid side chains are crucial mediators of biomolecular recognition, but their characterization by nuclear magnetic resonance (NMR) is often hindered by conformational and solvent exchange, particularly for arginine guanidinium groups.
Maria Anna Rodella, Marco Schiavina, Maksim Mayzel, Carlotta Cappanni, Rainer Kümmerle, Roberta Pierattelli, Isabella C. Felli   +6 more
wiley   +1 more source

Utilization profile of enoxaparin in hospitalized patients with Chronic Kidney Disease in southern Brazil

Brazilian Journal of Pharmaceutical Sciences, 2020
Chronic Kidney Disease (CKD) patients usually require the use of anticoagulants for treatment or prevention of thromboembolic diseases. One such commonly used anticoagulant is enoxaparin. However, special attention is advised when using this drug for CKD
Carolina Araujo Cirne, Tatiane Araujo Castro Machado   +1 more
doaj   +1 more source

Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction [PDF]

, 2013
BACKGROUNDIt is not known whether prehospital fibrinolysis, coupled with timely coronary angiography, provides a clinical outcome similar to that with primary percutaneous coronary intervention (PCI) early after acute ST-segment elevation myocardial ...
Armstrong, Paul W., Arntz, Hans-Richard, Bluhmki, Erich, Bogaerts, Kris, Carvalho, Antonio C., Danays, Thierry, Fresco, Claudio, Gershlick, Anthony H., Goldstein, Patrick, Grajek, Stefan, Halvorsen, Sigrun, Huber, Kurt, Lambert, Yves, Nanas, John, Ostojic, Miodrag, Regelin, Anne, Rosell Ortiz, Fernando, STREAM Investigative Team, Sulimov, Vitaly, Van de Werf, Frans, Vandenberghe, Katleen, Welsh, Robert C., Wilcox, Robert   +22 more
core   +1 more source

Risks of thrombosis and hemorrhage in concurrent use of anticoagulants and potential interacting prostate cancer agents

Cancer, Volume 132, Issue 6, 15 March 2026.
Abstract Background Pharmacokinetic studies suggest that specific prostate cancer therapies may alter the metabolism of direct oral anticoagulants (DOACs), leading to elevated risks of thrombosis or bleeding. Methods To assess the risk of thrombosis or bleeding, population‐based, retrospective, parallel analyses were conducted in Ontario and Alberta ...
Tzu‐Fei Wang, Anna Clarke, Mitchell Rath, Samantha Yoo, Deena Fremont, Cynthia Wu, Pietro Ravani, Dominick Bossé, Robert Talarico, Marc Carrier, Manish M. Sood   +10 more
wiley   +1 more source

Pancreatic ductal adenocarcinoma [PDF]

, 2013
A 61-year-old gentleman who lives with his wife and 20-year-old son, presented to the polyclinic with a four week history of pruritus. On examination he was found to be jaundiced and his LFTs were high.
Bezzina, Sarah, Debattista, Daniel
core