Results 111 to 120 of about 7,131,528 (351)

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice

eLife, 2019
Adult neurogenesis in the hippocampus may represent a form of plasticity in brain functions including mood, learning and memory. However, mechanisms underlying neural stem/progenitor cells (NSPCs) proliferation are not well understood.
Hongsheng Zhang, Anupama Sathyamurthy, Fang Liu, Lei Li, Lei Zhang, Zhaoqi Dong, Wanpeng Cui, Xiangdong Sun, Kai Zhao, Hongsheng Wang, Hsin-Yi Henry Ho, Wen-Cheng Xiong, Lin Mei   +12 more
doaj   +1 more source

Organization of the Modulopt collection of optimization problems in the Libopt environment -- Version 1.0 [PDF]

arXiv, 2007
This note describes how the optimization problems of the Modulopt collection are organized within the Libopt environment. It is aimed at being a guide for using and enriching this collection in this environment.
arxiv  

The colour-magnitude relation of Globular Clusters in Centaurus and Hydra - Constraints on star cluster self-enrichment with a link to massive Milky Way GCs [PDF]

, 2014
We investigate the colour-magnitude relation of metal-poor globular clusters, the 'blue tilt', in the Hydra and Centaurus galaxy clusters and constrain the primordial conditions for star cluster self-enrichment. We analyse U,I photometry for about 2500 globular clusters in the central regions of Hydra and Centaurus, based on FORS1@VLT data.
arxiv   +1 more source

Enriched environment effects on remote object recognition memory [PDF]

Neuroscience, 2017
Since Ebbinghaus' classical work on oblivion and saving effects, we know that declarative memories may become at first spontaneously irretrievable and only subsequently completely extinguished. Recently, this time-dependent path toward memory-trace loss has been shown to correlate with different patterns of brain activation.
Melani R, Chelini G, Cenni MC, Berardi N
openaire   +2 more sources

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer’s Disease, Improving Memory

Frontiers in Aging Neuroscience, 2018
Alzheimer’s disease (AD) is associated with a progressive dementia, and there is good evidence that it is more pronounced in individuals that have fewer stimuli during their lives.
Janaina Balthazar, Natalia Mendes Schöwe, Gabriela Cabett Cipolli, Hudson Sousa Buck, Tania Araujo Viel, Tania Araujo Viel   +5 more
doaj   +1 more source

Towards Reproducible Evaluations for Flying Drone Controllers in Virtual Environments [PDF]

arXiv, 2022
Research attention on natural user interfaces (NUIs) for drone flights are rising. Nevertheless, NUIs are highly diversified, and primarily evaluated by different physical environments leading to hard-to-compare performance between such solutions. We propose a virtual environment, namely VRFlightSim, enabling comparative evaluations with enriched drone
arxiv  

Comparative lipidomics of mouse brain exposed to enriched environment [PDF]

Journal of Lipid Research, 2013
Several studies have shown that housing conditions and environmental exposure to a series of stimuli lead to behavior improvement in several species. While more works have been focused on illustrating changes of the proteome and transcriptome following enriched environment exposure in mice, little has been done to understand changes in the brain ...
Makoto Nakagawa, Yoshiya Oda, Francois Bernier, Sadaharu Kotani, Ikumi Suzuki, Yoshiaki Sato   +5 more
openaire   +4 more sources

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source