Results 71 to 80 of about 1,893,563 (279)

ProbCD: enrichment analysis accounting for categorization uncertainty [PDF]

, 2007
As in many other areas of science, systems biology makes extensive use of statistical association and significance estimates in contingency tables, a type of categorical data analysis known in this field as enrichment (also over-representation or ...
A Lewin, A Vinayagam, B Engelhardt, C Andersson, C Jones, D Martin, E Levy, I Rivals, Ilya Shmulevich, J Goeman, L Goodman, M Aubry, P Shannon, R Fisher, R Sealfon, R Vencio, Ricardo ZN Vêncio, S Carroll, S Maere, T Joshi, W Zhang, W Zhang, Z Jiang   +22 more
core   +5 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Classroom enrichment through children's specialties. [PDF]

, 1952
Thesis (Ed.M.)--Boston ...
Clancy, Agnes A., Fitzpatrick, John L., Huntly, Bernard, Kelley, Ruth, Morrill, Katherine A., Mulcahey, Frances, Sheerin, James S., Sylvia, Dorothy   +7 more
core   +1 more source

Hopf measuring comonoids and enrichment

, 2016
We study the existence of universal measuring comonoids $P(A,B)$ for a pair of monoids $A$, $B$ in a braided monoidal closed category, and the associated enrichment of a category of monoids over the monoidal category of comonoids. In symmetric categories,
Franco, Ignacio Lopez, Hyland, Martin, Vasilakopoulou, Christina   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The Hottest Horizontal-Branch Stars in omega Centauri - Late Hot Flasher vs. Helium Enrichment

, 2007
UV observations of some massive globular clusters uncovered a significant population of very hot stars below the hot end of the horizontal branch (HB), the so-called blue hook stars.
Bono, G., Calamida, A., Dreizler, S., Lanz, T., Moehler, S., Monelli, M., Nonino, M., Sweigart, A. V.   +7 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Characteristics and main controlling factors of organic pore development in continental shales of the Lianggaoshan Formation in the Fuxing area, Sichuan Basin

Shiyou shiyan dizhi
The Lianggaoshan Formation in the Fuxing area of the Sichuan Basin has developed a typical set of medium to high maturity continental shale condensate oil reservoirs.
Pengwei WANG, Baojian SHEN, Zhongbao LIU, Min LI, Qianwen LI, Jia RONG, Qianru WANG   +6 more
doaj   +1 more source