Results 111 to 120 of about 2,778,759 (291)

STEM-based e-module on excretory system to enhance high school students’ critical thinking and independence

JPBI (Jurnal Pendidikan Biologi Indonesia)
Enrichment programs are important for maximizing capabilities and improving mastery skills 21st century, however, their implementation does not maximize the material system excretion.
Eko Sucipto, Kartika Ratna Pertiwi
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Integrated bulk and single-cell transcriptomic analyses identify transcriptome-defined groups and EGFR-associated microenvironmental programs in glioma

Discover Oncology
Background Glioma exhibits significant molecular heterogeneity, necessitating improved understanding of molecular subtypes for personalized treatment strategies. Methods This study integrated bulk RNA sequencing (GSE35169) to derive transcriptome-defined
Yuanhan Wang, Long Li, Xing Hu, Longhu Han, Yihan Zhang, Zhisen Zhou, Wei Liu, Song Yang   +7 more
doaj   +1 more source

Doctor for a day: the impact of a health professions enrichment program on self-efficacy

Frontiers in Medicine
IntroductionHealth profession enrichment programs for underrepresented minority students are crucial to supporting students’ interest in healthcare careers and improving preparedness for important academic and professional milestones.
Celeste Coler, Kareena Patel, A. J. Balatico, Kumhee Ro, Joshua Villarreal, Nora Coronado, Estell Williams   +6 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Environmental enrichment affects growth and behaviour differently in head-started critically endangered freshwater turtles

Scientific Reports
Freshwater chelonians face severe extinction risk, and head-starting programs increasingly rely on captive rearing to offset poor recruitment. However, evaluating success by growth and release numbers overlooks welfare and post-release competence.
Ashish Kumar Panda, Debdulal Jana, Anupam Srivastav, Syed Ainul Hussain, Ruchi Badola   +4 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Linking Personality and Performance in California Sea Lions (Zalophus californianus) During Computerized Cognitive Enrichment

Animals
Cognitive enrichment is increasingly recognized as an important component of marine mammal welfare, offering animals opportunities for choice, problem solving, and sustained engagement.
Amber Ramos, Kelley Winship
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source