Results 81 to 90 of about 328,404 (292)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Current Perspectives on Viable but Non-Culturable (VBNC) Pathogenic Bacteria

Frontiers in Public Health, 2014
Under stress conditions, many species of bacteria enter into starvation mode of metabolism or a physiologically viable but non-culturable (VBNC) state.
Thandavarayan eRamamurthy, Amit eGhosh, Gururaja Perumal Pazhani, Sumio eShinoda   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Vibrio fluvialis: An Emerging Pathogen

Frontiers in Microbiology, 2014
Vibrio fluvialis is a pathogen commonly found in costal environs. Considering recent increase in numbers of diarrheal outbreaks and sporadic extraintestinal cases, V. fluvialis has been considered as an emerging pathogen.
Thandavarayan eRamamurthy, Goutam eChowdhury, Gururaja P Pazhani, Sumio eShinoda   +3 more
doaj   +1 more source

Abundance and Distribution of Enteric Bacteria and Viruses in Coastal and Estuarine Sediments—a Review [PDF]

, 2016
The long term survival of fecal indicator organisms (FIOs) and human pathogenic microorganisms in sediments is important from a water quality, human health and ecological perspective.
Abdelzaher, Alcântara, Alkan, Allison, Allwood, Amel, Anderson, Arana, Arnold, Arnon, Artz, Asakura, Atkinson, Auer, Avery, Ayrapetyan, Ayrapetyan, Bae, Banning, Bari, Bauman, Berthe, Bilge, Bitton, Bonilla, Borade, Bosch, Bryers, Burton, Busscher, Byappanahalli, Byappanahalli, Cai, Cangelosi, Cao, Carlson, Carr, Carreira, Castro, Cellini, Chan, Charles, Cheville, Chigbu, Chrysikopoulos, Chrysikopoulos, Cook, Cooper, Costerton, Cox, Crabill, Czajkowska, Dancho, Danovaro, Darcan, Davies, de Brauwere, de Brouwer, Deloffre, Dobrindt, Doré, Dowd, Drummond, Drummond, Duhamel, Dulbecco, Ervin, Evanson, Farkas, Ferguson, Filip, Filippini, Fongaro, Foppen, Foppen, Fu, Fukushima, Furtak, Garzio-Hadzick, Geldreich, Gerba, Gerba, Gerba, Gerba, Gerba, Gilbert, Gin, Girones, Goldscheider, Gomez-Suarez, Gottenbos, Goyal, Green, Greening, Guizien, Gwyther, Hadjiev, Haller, Halpern, Hamdan, Harvey, Hassard, Hazen, He, Heijnen, Henry, Henson, Hermansson, Hong, Howell, Howlett, Huang, Ikner, Ishii, Jamieson, Jamieson, Jiang, Jin, John, Johnson, Junkins, Kay, Kerr, Khan, Kierek, Kim, Kirschner, Kitajima, Klayman, Korajkic, Korber, LaBelle, LaBelle, Le Guyader, Lee, LeJeune, Lemos, Lewis, Lewis, Li, Lieleg, Liew, Lorite, Lothigius, Lowther, Lucena, Luna, Madsen, Malham, Malic, Maule, McGee, Meays, Melnick, Meschke, Mills, Miura, Moce-Llivina, Muirhead, Nasser, Neave, Nocker, Norman, Obiri-Danso, Ogorzaly, Ohtomo, Oliver, Oliver, Oliver, Oliver, Ouattara, Ouattara, Pachepsky, Pachepsky, Pachepsky, Paez-Espino, Pang, Park, Passerat, Paul, Payne, Peneau, Perkins, Petterson, Piggot, Pinto, Port, Poulsen, Props, Quignon, Quilliam, Quilliam, Ramaiah, Ramamurthy, Randa, Rao, Rao, Rao, Ren, Rice, Rice, Ritchie, Rock, Roper, Roper, Rosenwasser, Rozen, Ryu, Saby, Samandoulgou, Scherber, Schijven, Scholl, Schultz-Fademrecht, Sen, Setti, Shahrampour, Shelton, Siem-Jorgensen, Signoretto, Singh, Sinton, Skraber, Skraber, Smets, Smith, Soares de Lima Grisi, Solo-Gabriele, Staggemeier, Staggemeier, Stal, Staley, Stapleton, Stenström, Stephenson, Storch, Stumpf, Suhalim, Sutherland, Tan, Thorn, Troussellier, Tsai, van der Mei, Van Houdt, van Loosdrecht, van Loosdrecht, Vignaroli, Vignaroli, Villanueva, Wait, Wallner, Walter, Walters, Wang, Wang, Ward, Watterworth, Weinbauer, Weiss, Williams, Williams, Williamson, Wingender, Wu, Yamahara, Yaron, Yoshida, Young, Zhang   +269 more
core   +5 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Assembly, Biochemical Characterization, Immunogenicity, Adjuvanticity, and Efficacy of Shigella Artificial Invaplex

mSphere, 2018
The native Invaplex (InvaplexNAT) vaccine and adjuvant is an ion exchange-purified product derived from the water extract of virulent Shigella species.
K. Ross Turbyfill, Kristen A. Clarkson, Anthony R. Vortherms, Edwin V. Oaks, Robert W. Kaminski   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source