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The Enteric Nervous System and Its Emerging Role as A Therapeutic Target

Gastroenterology Research and Practice, 2020
The gastrointestinal (GI) tract is innervated by the enteric nervous system (ENS), an extensive neuronal network that traverses along its walls. Due to local reflex circuits, the ENS is capable of functioning with and without input from the central ...
Mark Fleming, Lubaina Ehsan, Sean Moore, Daniel E. Levin   +3 more
openalex   +3 more sources

Enteric nervous system

, 2020
Matt Morgan, Daniel Bell
openalex   +2 more sources

Identification of a rhythmic firing pattern in the enteric nervous system that generates rhythmic electrical activity in smooth muscle [PDF]

Journal of Neuroscience, 2018
The enteric nervous system (ENS) contains millions of neurons essential for organization of motor behavior of the intestine. It is well established that the large intestine requires ENS activity to drive propulsive motor behaviors.
Brookes, Simon J, Costa, Marcello, Dinning, Phil G, Hibberd, Timothy J, Hu, Hongzhen, Keating, Damien J, Sorensen, Julian, Spencer, Nick J, Travis, Lee, Wattchow, David A, Wiklendt, Lukasz   +10 more
core   +3 more sources

Enteric nervous system as a therapeutic target in gastrointestinal disorders. [PDF]

World J Gastrointest Pharmacol Ther
Agrawal H, Agarwal N, Gupta N.
europepmc   +2 more sources

Crosstalk between omega-6 oxylipins and the enteric nervous system: Implications for gut disorders?

Frontiers in Medicine, 2023
The enteric nervous system (ENS) continues to dazzle scientists with its ability to integrate signals, from the outside as well as from the host, to accurately regulate digestive functions.
Marine Mantel, Pascal Derkinderen, Kalyane Bach-Ngohou, Michel Neunlist, Malvyne Rolli-Derkinderen   +4 more
doaj   +1 more source

Psychological stress induces an increase in cholinergic enteric neuromuscular pathways mediated by glucocorticoid receptors

Frontiers in Neuroscience, 2023
IntroductionRepeated acute stress (RASt) is known to be associated with gastrointestinal dysfunctions. However, the mechanisms underlying these effects have not yet been fully understood.
Justine Blin, Justine Blin, Camille Gautier, Philippe Aubert, Tony Durand, Thibauld Oullier, Laetitia Aymeric, Laetitia Aymeric, Philippe Naveilhan, Damien Masson, Damien Masson, Michel Neunlist, Kalyane Bach-Ngohou, Kalyane Bach-Ngohou   +13 more
doaj   +1 more source

Enteric Nervous System: The Bridge Between the Gut Microbiota and Neurological Disorders

Frontiers in Aging Neuroscience, 2022
The gastrointestinal (GI) tract plays an essential role in food digestion, absorption, and the mucosal immune system; it is also inhabited by a huge range of microbes.
Zifan Geng, Yan Zhu, Quan-Lin Li, Chao Zhao, P. Zhou   +4 more
semanticscholar   +1 more source

Region-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients

Scientific Reports, 2023
Patients with spinal cord injury (SCI) suffer from major bowel dysfunction, whose exact pathophysiology, particularly the involvement of the enteric nervous system or epithelial dysfunction is poorly understood.
Chloë Lefèvre, Camille Le Roy, Anne Bessard, Catherine Le Berre-Scoul, Justine Marchix, Emmanuel Coron, Marc Le Rhun, Charlène Brochard, Brigitte Perrouin-Verbe, Michel Neunlist   +9 more
doaj   +1 more source

Could the Microbiota Be a Predictive Factor for the Clinical Response to Probiotic Supplementation in IBS-D? A Cohort Study

Microorganisms, 2023
Background: Increasing evidence suggests the beneficial effects of probiotics in irritable bowel syndrome (IBS), but little is known about how they can impact the gut microbiota. Our objective was to evaluate the effects of a multistrain probiotic on IBS
Justine Marchix, Lucille Quénéhervé, Philippe Bordron, Philippe Aubert, Tony Durand, Thibauld Oullier, Claude Blondeau, Samira Ait Abdellah, Stanislas Bruley des Varannes, Samuel Chaffron, Emmanuel Coron, Michel Neunlist   +11 more
doaj   +1 more source

A functional network of highly pure enteric neurons in a dish

Frontiers in Neuroscience, 2023
The enteric nervous system (ENS) is the intrinsic nervous system that innervates the entire digestive tract and regulates major digestive functions. Recent evidence has shown that functions of the ENS critically rely on enteric neuronal connectivity ...
Martial Caillaud, Morgane E. Le Dréan, Adrien De-Guilhem-de-Lataillade, Catherine Le Berre-Scoul, Jérôme Montnach, Steven Nedellec, Gildas Loussouarn, Vincent Paillé, Michel Neunlist, Hélène Boudin   +9 more
doaj   +1 more source