Clinical outcomes of Enterobacteriaceae infections stratified by carbapenem MICs. [PDF]
ABSTRACT The Clinical and Laboratory Standards Institute (CLSI) lowered the MIC breakpoints for meropenem and imipenem from 4 mg/liter to 1 mg/liter for Enterobacteriaceae in 2010. The breakpoint change improves the probability of pharmacodynamic target attainment and eliminates the need for microbiology ...
Patel TS, Nagel JL.
europepmc +4 more sources
Management of carbapenem-resistant Enterobacteriaceae infections [PDF]
Carbapenem resistance is defined as in vitro non-susceptibility to any carbapenem and/or documented production of a carbapenemase. This feature has rapidly spread worldwide among clinical isolates of Enterobacteriaceae, mostly Klebsiella spp., and is associated with diverse molecular mechanisms. Carbapenem resistance is often associated with resistance
Durante-Mangoni, Emanuele +2 more
openaire +3 more sources
Antibiotic resistance pattern of clinical isolates of ESBL strains and determination of enzymatic relationship with clinical specimen type [PDF]
Background: Differences in clinical isolates may affect the frequency of Extended Spectrum Beta-Lactamase enzymes (ESBLs) in some gram-negative bacteria.
Mahyar Porbaran +2 more
doaj +1 more source
Beta-lactamases in Enterobacteriaceae infections in children [PDF]
Multi-drug resistance in Gram negative bacteria, particularly in Enterobacteriaceae, is a major clinical and public health challenge. The main mechanism of resistance in Enterobacteriaceae is linked to the production of beta-lactamase hydrolysing enzymes such as extended spectrum beta-lactamases (ESBL), AmpC beta-lactamases and carbapenemases ...
Moxon, Christopher Alan +1 more
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INCIDENCE OF ENTEROBACTERIACEAE IN NOSOCOMIAL INFECTIONS
This work was carried out in the field of General Microbiology, combining in its contents elements of different biological, medical and technological disciplines.The special part of this paper included a study at the Tg-Jiu County Emergency Hospital, where we made a statistic during a calendar year on the number of hospitalized patients, detected with ...
Eleonora Daniela Ciupeanu Călugăru +1 more
openaire +1 more source
In vitro activity of tigecycline against local clinical isolates of some Enterobacteriaceae
Infectious diseases that Enterobacteriaceae cause are spreading on a wide scale. Examples of these infections are gastrointestinal tract infections, meningitis, pneumonia, septicemia, urinary tract infections, and wound infections. Antibiotic resistance
Hadeel Eldeeb +3 more
doaj +1 more source
Treatment of Infections by OXA-48-Producing Enterobacteriaceae [PDF]
Carbapenemase-producing Enterobacteriaceae (CPE) contribute significantly to the global public health threat of antimicrobial resistance. OXA-48 and its variants are unique carbapenemases with low-level hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins.
Adam Stewart +3 more
openaire +5 more sources
Treating infections caused by carbapenemase-producing Enterobacteriaceae [PDF]
Carbapenemase-producing Enterobacteriaceae (CPE) have spread worldwide, causing serious infections with increasing frequency. CPE are resistant to almost all available antibiotics, complicating therapy and limiting treatment options. Mortality rates associated with CPE infections are unacceptably high, indicating that the current therapeutic approaches
Tzouvelekis, L.S. +4 more
openaire +3 more sources
Colistin Resistance among Enterobacteriaceae Isolated from Clinical Samples in Gaza Strip
Bacterial infections, especially drug-resistant infections, are a major global health issue. The emergence of multidrug-resistant (MDR) strains of Enterobacteriaceae and the lack of new antibiotics have worrisome prospects for all of humanity.
Mohammad Qadi +3 more
doaj +1 more source
Characterization of two polyvalent phages infecting Enterobacteriaceae [PDF]
AbstractBacteriophages display remarkable genetic diversity and host specificity. In this study, we explore phages infecting bacterial strains of the Enterobacteriaceae family because of their ability to infect related but distinct hosts. We isolated and characterized two novel virulent phages, SH6 and SH7, using a strain of Shigella flexneri as host ...
Sana Hamdi +6 more
openaire +2 more sources

