Results 31 to 40 of about 182,477 (300)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Analysis Of Selected Genetic Traits, Phenotypes, And The Epidemiological Threat Of Enterococcus Bacteria Resistant To Vancomycin

Postępy Mikrobiologii, 2019
Enterococci are Gram-positive bacteria that belong to facultative anaerobic cocci. Species belonging to the Enterococcus genus generally display little infectious potential, although they can cause serious nosocomial infections.
Rogóż Wojciech, Sypniewski Daniel, Bednarek Ilona   +2 more
doaj   +1 more source

Coliformes termotolerantes e enterococcus SP em ostras e águas salinas utilizadas para cultivo de moluscos bivalves da Baia Sul da Ilha de Santa Catarina - Brasil [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Ciência dos Alimentos, Florianópolis, 2009.Este trabalho teve por objetivo pesquisar a incidência de bactérias indicadoras de ...
Miotto, Letícia Adélia
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

Características bacteriológicas, físicas y pH del agua de consumo humano del municipio de Une-Cundinamarca.

NOVA, 2020
Objetivo. Determinar características bacteriológicas, físicas y pH del agua para consumo humano que abastece al municipio de Une, Cundinamarca-Colombia. Métodos. Se tomaron 13 muestras de agua: 10 de la zona rural y 3 de la zona urbana.
Sandra Mónica Estupiñán-Torres, Sara Lilia Ávila de Navia, Diego Barrera Aguirre, Robinson Baquero Torres, Delith Allexandra Díaz Ibañez, Anthony Hever Rodríguez Ramírez   +5 more
doaj  

an Kültürlerinden İzole Edilen Enterokok Suşlarının Antibiyotik Direnci

Sakarya Tıp Dergisi, 2013
Giriş: Enterokok türleri, toplum ve hastane kökenli infeksiyon etkenleri arasında giderek önem kazanmaktadır. Çalışmada, enterokok türlerinin bölgemizdeki direnç durumlarının belirlenmesi amaçlanmıştır.
Ayşe Özkaçmaz, Aytekin Çıkman, Hüseyin Güdücüoğlu, Mehmet Parlak, Mustafa Berktaş   +4 more
doaj   +1 more source

Biofilm Formation by Drug Resistant Enterococci Isolates Obtained from Chronic Periodontitis Patients [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Enterococci are an important cause of opportunistic nosocomial infections and several multidrug resistant strains have emerged. The severity of periodontal diseases is managed by reduction in the pathogenic bacteria.
Sonia Bhonchal Bhardwaj, Manjula Mehta, Shaveta Sood, Jyoti Sharma   +3 more
doaj   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources