Results 11 to 20 of about 3,281 (193)

JAK Inhibitor Upadacitinib Induces Remission in Refractory Immune-Related Colitis Triggered by CTLA-4 and PD-1 Inhibitor Combination Therapy in Malignant Pleural Mesothelioma: A Case Report. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Immune checkpoint inhibitors have demonstrated efficacy against various cancers; however, there is a rising incidence of immune‐related colitis. Some cases of immune‐related colitis prove resistant to treatment, even with the administration of glucocorticoids or infliximab, and there is currently no established standard treatment ...
Kono M, Komeda Y, Kawakami H, Hagiwara S, Tribonias G, Handa K, Omoto S, Takenaka M, Kashida H, Tsuji N, Kudo M.   +10 more
europepmc   +2 more sources

Role of TLR4 in Enteric Glia Response to Clostridioides Difficile Toxins: Insights From In Vivo and In Vitro Studies. [PDF]

J Cell Mol Med
ABSTRACT Clostridioides difficile (C. difficile ) is a Gram‐positive anaerobic bacillus that causes intestinal disorders. Toll‐like receptor 4 (TLR4) plays a key role in innate immunity. This study examines the role of TLR4 in the response to C. difficile toxins, which induce cell death and inflammatory responses in enteric glial cells (EGCs).
Barbosa MLL, Costa DVDS, de Pacífico DM, Rebouças CDSM, Warren CA, de Leitão RFC, Brito GAC.   +6 more
europepmc   +2 more sources

Refractory Infection Cured With Fecal Microbiota Transplantation in Vancomycin-Resistant Enterococcus Colonized Patient [PDF]

Intestinal Research, 2015
The rates and severity of Clostridium difficile infections, including pseudomembranous colitis, have increased markedly. However, there are few effective treatments for refractory or recurrent C. difficile infections and the outcomes are poor.
Mi-Ok Jang, Jun Hwan An, Sook-In Jung, Kyung-Hwa Park   +3 more
doaj   +1 more source

Pseudomembranous colitis in children: Experience of a university hospital in Korea [PDF]

, 2010
Purpose : Pseudomembranous colitis (PMC) occurs rarely in children, but its incidences are increasing due to frequent antibiotic use. We investigated the incidence and clinical characteristics of PMC accompanied by bacterial enteritis-like symptoms in ...
Ae Suk Kim, Bartlett, Bartlett, Biddle, Brook, Burgner, Cleary, Gerding, Holmes, Hookman, Jae Hyun Park, Jin-Bok Hwang, Kim, Kim, Kyung Ji Kang, McFarland, Nair, Olofinlade, Park, Price, Ramaswamy, Savidge, Starr, von Eichel-Streiber, Wanahita, Wenzl, Yu Na Kang, Zwiener   +27 more
core   +1 more source

Laboratorium Diagnosis of Clostridium Difficile Infection [PDF]

, 2006
Clostridium difficile is the most important cause of antibiotic associated diarrhea, and pseudomembranous colitis, a severe infection of the colon.
Legoh, G. N. (Grace), Sosrosumihardjo, R. (Rustadi)   +1 more
core   +1 more source

An epidemiological surveillance study (2021–2022): detection of a high diversity of Clostridioides difficile isolates in one tertiary hospital in Chongqing, Southwest China

BMC Infectious Diseases, 2023
Background Clostridioides difficile is a bacterium that causes antibiotic-associated infectious diarrhea and pseudomembranous enterocolitis. The impact of C. difficile infection (CDI) in China has gained significant attention in recent years.
Yihong Cui, Chuanming Zhang, Qianying Jia, Xue Gong, Yu Tan, Xinping Hua, Wenwen Jian, Shenglin Yang, Kim Hayer, Raja Kamarudin Raja Idris, Yi Zhang, Yuan Wu, Zeng Tu   +12 more
doaj   +1 more source

Faecal microbiota transplantation : a regulatory hurdle? [PDF]

, 2017
During faecal microbiota transplantation, stool from a healthy donor is transplanted to treat a variety of dysbiosis-associated gut diseases. Competent authorities are faced with the challenge to provide adequate regulation.
De Spiegeleer, Bart, Janssens, Yorick, Verbeke, Frederick, Wynendaele, Evelien   +3 more
core   +2 more sources

Fecal Transplantation for —“All Stool May Not Be Created Equal”

Journal of the International Association of Providers of AIDS Care, 2016
Clostridium difficile is a gram-positive bacterium that is recognized as a causative organism of pseudomembranous enterocolitis. This infection has become a major public health challenge and is a source of considerable morbidity and mortality in those ...
Joseph C. Gathe MD, FACP, FIDSA, Efemena M. Diejomaoh MBBS, Carl C. Mayberry PA, John B. Clemmons MD   +3 more
doaj   +1 more source

Hospitalizations and Deaths Associated with Clostridium difficile Infection, Finland, 1996–2004

Emerging Infectious Diseases, 2009
To determine whether the rate of Clostridium difficile–associated disease (CDAD) and CDAD-related deaths were increasing in Finland, we analyzed registry data from 1996 through 2004.
Outi Lyytikäinen, Heli Turunen, Reijo Sund, Marja Rasinperä, Eija Könönen, Petri Ruutu, Ilmo Keskimäki   +6 more
doaj   +1 more source

Fecal microbiota transplants: Emerging social representations in the English-language print media [PDF]

, 2019
open access articleThis study investigates how English-language news sources have represented fecal microbiota transplants (FMT). FMT involves transferring stool from a healthy donor to a recipient with a dysfunctional intestinal flora in order to ...
Jaspal, Rusi, McLeod, Carmen, Nerlich, Brigitte   +2 more
core   +4 more sources