Results 91 to 100 of about 10,640,678 (241)

CellOntologyMapper: Consensus mapping of cell type annotation

iMetaOmics, EarlyView.
CellOntologyMapper automates the standardization of cell type annotations in single‐cell RNA‐seq by mapping user‐defined names to the Cell Ontology (CL) and Cell Taxonomy (CT). The framework constructs a comprehensive embedding database of 19,381 curated cell types using sentence transformers, large language models, and synonym expansion.
Zehua Zeng, Xuehai Wang, Hongwu Du, Cencan Xing   +3 more
wiley   +1 more source

Cell fluorescence analysis for midgut enteroendocrine cells

, 2022
ImageJ tutorial for creating binary cell image and MatLab script for quantifying fluorescence intensity of three confocal channels. This code pulls out data from relevant Z-stacks only and uses local background for background subtraction.
openaire   +1 more source

Diabetes-preventive molecular mechanisms of breast versus formula feeding: new insights into the impact of milk on stem cell Wnt signaling

Frontiers in Nutrition
Human milk serves as a transmitter for epigenetic programming involved in postnatal tissue development and organ maturation of the infant. In contrast to formula feeding (FF), prolonged breastfeeding (BF) has been associated with diabetes-preventive ...
Bodo C. Melnik, Ralf Weiskirchen, Sabine Weiskirchen, Wolfgang Stremmel, Swen M. John, Swen M. John, Claus Leitzmann, Gerd Schmitz   +7 more
doaj   +1 more source

Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery

Cell Reports, 2019
Summary: Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and insulin are widely
Pierre Larraufie, Geoffrey P. Roberts, Anne K. McGavigan, Richard G. Kay, Joyce Li, Andrew Leiter, Audrey Melvin, Emma K. Biggs, Peter Ravn, Kathleen Davy, David C. Hornigold, Giles S.H. Yeo, Richard H. Hardwick, Frank Reimann, Fiona M. Gribble   +14 more
doaj   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

Intestinal Neurod1 expression impairs paneth cell differentiation and promotes enteroendocrine lineage specification

Scientific Reports, 2019
Transcription factor Neurod1 is required for enteroendocrine progenitor differentiation and maturation. Several earlier studies indicated that ectopic expression of Neurod1 converted non- neuronal cells into neurons.
H. J. Li, S. K. Ray, Ning Pan, J. Haigh, Bernd Fritzsch, A. Leiter   +5 more
semanticscholar   +1 more source

Clinical, manometric, genetic, and histologic associations in pediatric intestinal pseudo‐obstruction: A case series

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric intestinal pseudo‐obstruction (PIPO) is a severe bowel motility disorder characterized by impaired propulsion of gastrointestinal contents without mechanical obstruction. PIPO encompasses congenital and acquired disorders, including neuropathies, myopathies, and mesenchymopathies.
Sharon Wolfson, Myra Butrviengpunt, Naomi Tjaden, Alain J. Benitez, Archana S. Kota, Jennifer Webster, Prasanna Kapavarapu, Hayat Mousa, Robert O. Heuckeroth   +8 more
wiley   +1 more source

Expanding the genotypic spectrum of PCSK1 deficiency: A novel mutation in severe neonatal diarrhea

JPGN Reports, EarlyView.
Abstract Among congenital diarrhea and enteropathies (CODEs), proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency is a rare monogenic disorder, associated with severe neonatal diarrhea and polyendocrinopathies. We report an 18‐day‐old male neonate, born to consanguineous parents, presenting with persistent watery diarrhea, metabolic ...
Eleonora Saraceno, Angelo Corso Faini, Silvia Deaglio, Marianna Pellegrini, Raffaele Buganza, Francesca Giuliani, Pier Luigi Calvo, Michele Pinon   +7 more
wiley   +1 more source

PERCC1‐associated enteropathy: Diagnostic challenges and enteral autonomy achieved with teduglutide

JPGN Reports, EarlyView.
Abstract Congenital diarrheas and enteropathies (CODE) are rare inherited disorders characterized by early‐onset intractable diarrhea. Though progress has been made in elucidating the genetic basis of CODE, much remains to be discovered. Another challenge is the lack of curative therapies—treatment is primarily supportive including enteral and ...
Angela Tran, Vivien Nguyen, Phuong Huynh
wiley   +1 more source

Is AMP‐activated protein kinase activation a central mechanism of cardio‐metabolic outcomes after metabolic and bariatric surgery?

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity. It usually results in spectacular weight loss, associated with improvements of obesity‐associated comorbidities. The mechanisms underlying these benefits are not fully understood but could involve a postoperative activation of the enzyme 5′ AMP‐activated ...
Adrien Delcour, Nathalie Niederhoffer
wiley   +1 more source