Results 151 to 160 of about 10,616,742 (287)

Metabolic and appetitive regulation of adipocyte mass during treatment of obesity

open access: yesJournal of Internal Medicine, Volume 299, Issue 1, Page 66-78, January 2026.
Abstract Adipose mass is homeostatically maintained within a narrow range despite fluctuations in daily calorie intake and activity levels. Constituting an adipose mass “set point,” this homeostatic regulation includes sensing mechanisms in the form of hormones reflecting caloric intake that serve as mediators of appetitive behaviors and adipose mass ...
Jonathan Q. Purnell, Carel W. Le Roux
wiley   +1 more source

Cdk4 functions in multiple cell types to control Drosophila intestinal stem cell proliferation and differentiation

open access: yesBiology Open, 2016
The proliferation of intestinal stem cells (ISCs) and differentiation of enteroblasts to form mature enteroendocrine cells and enterocytes in the Drosophila intestinal epithelium must be tightly regulated to maintain homeostasis.
Mojca Adlesic   +2 more
doaj   +1 more source

Teduglutide in pediatric patients under 10 kg with short bowel syndrome on parenteral support: An open‐label study

open access: yesPediatrics International, Volume 68, Issue 1, January/December 2026.
Abstract Background Patients with short bowel syndrome (SBS)‐associated intestinal failure (SBS‐IF) are dependent on parenteral support (PS). In Japan, teduglutide is the only GLP‐2 analog medicine indicated for these patients. There are limited data for pediatric patients, especially those with a low body weight.
Kouji Masumoto   +9 more
wiley   +1 more source

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells

open access: yesJournal of Visualized Experiments, 2017
The gut is the largest endocrine organ of the body, with hormone-secreting enteroendocrine cells located along the length of the gastrointestinal epithelium. Despite their physiological importance, enteroendocrine cells represent only a small fraction of
A. Psichas   +4 more
semanticscholar   +1 more source

Characterization of a Bovine Serum Albumin‐Derived Pro‐Cognitive Peptide (bSAPP): An Orally Active Peptide Alleviates Cognitive Decline in HFD‐Fed Mice via CCK Signaling Through the Gut‐Brain Axis

open access: yesThe FASEB Journal, Volume 39, Issue 24, 31 December 2025.
The popularity of the Western diet has increased the prevalence of dementia in addition to aging. We found that the digest of bovine serum albumin and a peptide derived from the digest showed an oral pro‐cognitive effect in mice fed a high‐fat diet (HFD). We named the peptide bSAPP (EC50 = 0.01 mg/kg BW). The oral effect of bSAPP was modulated by CCK1R
Biyun Zhang   +5 more
wiley   +1 more source

The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine

open access: yesNature Communications, 2019
Notch signaling mediates intestinal enteroblast specification in Drosophila but the molecular mechanism as to how this is regulated is unclear. Here, the authors show that the transcription factor Klumpfuss ensures enteroblast commitment through ...
Jerome Korzelius   +9 more
doaj   +1 more source

Human enteroendocrine cell responses to infection with Chlamydia trachomatis: a microarray study

open access: yesGut Pathogens, 2014
BackgroundEnteroendocrine cells (EEC) are highly specialized cells producing signalling molecules vital to the normal functions of the gut. Recently, we showed altered protein distribution in Chlamydia infected EEC in vitro.
A. Dlugosz   +5 more
semanticscholar   +1 more source

Enteroendocrine cells express functional Toll-like receptors

open access: yesAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2007
Intestinal epithelial cells (IECs) provide a physical and immunological barrier against enteric microbial flora. Toll-like receptors (TLRs), through interactions with conserved microbial patterns, activate inflammatory gene expression in cells of the innate immune system.
Milena, Bogunovic   +7 more
openaire   +3 more sources

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