Results 31 to 40 of about 20,295 (209)

Asymmetric mucosal structure, mesenteric versus antimesenteric, in mouse, rat, and human small intestines

Physiological Reports, 2022
The morphology of the small intestinal mucosa is reflected by the degree of stimuli. Previous studies have come to different conclusion about whether the mucosa is equally symmetrical.
Anna Casselbrant, Herbert F. Helander
doaj   +1 more source

The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice.

PLoS ONE, 2012
Intestinal hormones are key regulators of digestion and energy homeostasis secreted by rare enteroendocrine cells. These cells produce over ten different hormones including GLP-1 and GIP peptides known to promote insulin secretion. To date, the molecular
Anthony Beucher, Elisabet Gjernes, Caitlin Collin, Monica Courtney, Aline Meunier, Patrick Collombat, Gérard Gradwohl   +6 more
doaj   +1 more source

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

Cell Reports, 2017
Summary: Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity.
Lorène J. Lebrun, Kaatje Lenaerts, Dorien Kiers, Jean-Paul Pais de Barros, Naig Le Guern, Jiri Plesnik, Charles Thomas, Thibaut Bourgeois, Cornelis H.C. Dejong, Matthijs Kox, Inca H.R. Hundscheid, Naim Akhtar Khan, Stéphane Mandard, Valérie Deckert, Peter Pickkers, Daniel J. Drucker, Laurent Lagrost, Jacques Grober   +17 more
doaj   +1 more source

Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects. [PDF]

PLoS ONE, 2016
Bitter taste receptors (T2Rs) are expressed in the mammalian gastrointestinal mucosa. In the mouse colon, T2R138 is localized to enteroendocrine cells and is upregulated by long-term high fat diet that induces obesity. The aims of this study were to test
Rocco Latorre, Jennifer Huynh, Maurizio Mazzoni, Arpana Gupta, Elena Bonora, Paolo Clavenzani, Lin Chang, Emeran A Mayer, Roberto De Giorgio, Catia Sternini   +9 more
doaj   +1 more source

Analysis of enteroendocrine cell populations in the human colon [PDF]

Cell and Tissue Research, 2016
Recent studies have shown that patterns of colocalisation of hormones in enteroendocrine cells are more complex than previously appreciated and that the patterns differ substantially between species. In this study, the human sigmoid colon is investigated by immunohistochemistry for the presence of gastrointestinal hormones and their colocalisation. The
Martins, Patricia, Fakhry, Josiane, de Oliveira, Enio Chaves, Hunne, Billie, Fothergill, Linda J, Ringuet, Mitchell, Reis, Débora d'Ávila, Rehfeld, Jens F, Callaghan, Brid, Furness, John B   +9 more
openaire   +3 more sources

High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting

Molecular Metabolism, 2017
Objective: α-cells are the second most prominent cell type in pancreatic islets and are responsible for producing glucagon to increase plasma glucose levels in times of fasting. α-cell dysfunction and inappropriate glucagon secretion occur in both type 1
Amanda M. Ackermann, Jia Zhang, Aryel Heller, Anna Briker, Klaus H. Kaestner   +4 more
doaj   +1 more source

HISTOMORPHOLOGICAL STUDY OF ENDOCRINE CELLS IN VARIOUS REGION OF DIGESTIVE TRACT OF BUFFALO (BUBALUS BUBALIS) [PDF]

Exploratory Animal and Medical Research, 2014
The histomorphology of enteroendocrine cells were studied in different segments of gastrointestinal tract of six adult buffalo. Depending upon the histomorphological study, the enteroendocrine cells were divided into 7 different types viz.
S. Dehury, R.K. Das, U.K. Mishra, G.R. Sahoo, R. Patra   +4 more
doaj  

Developmental Comparative Analysis of Enteroendocrine Hormone Immunoreactive Cells in the Abomasum and Small Intestine of Holstein–Friesian Bulls

Animals
Within the complex regulatory network of the gastrointestinal tract, enteroendocrine cells play a fundamental role in coordinating digestive processes and maintaining metabolic balance.
Ligia Janicka, Aleksandra Dajnowska, Katarzyna Woźniak, Cezary Osiak-Wicha, Katarzyna Kras, Iwona Łuszczewska-Sierakowska, Marcin B. Arciszewski   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source