Results 21 to 30 of about 20,295 (209)

Free Fatty Acid Receptors in Enteroendocrine Cells [PDF]

Endocrinology, 2018
Free fatty acid receptors (FFAs) are highly enriched in enteroendocrine cells providing pathways to link dietary fats and microbially generated short-chain fatty acids (SCFAs) to the secretion of a variety of gut hormones. FFA1 and FFA4 are receptors for long-chain fatty acids that have been linked to the elevation of plasma gut hormones after fat ...
Lu, Van B, Gribble, Fiona M, Reimann, Frank   +2 more
openaire   +2 more sources

Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production

Molecular Metabolism, 2019
Objective: Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage.
Julie Piccand, Constance Vagne, Florence Blot, Aline Meunier, Anthony Beucher, Perrine Strasser, Mari L. Lund, Sabitri Ghimire, Laure Nivlet, Céline Lapp, Natalia Petersen, Maja S. Engelstoft, Christelle Thibault-Carpentier, Céline Keime, Sara Jimenez Correa, Valérie Schreiber, Nacho Molina, Thue W. Schwartz, Adèle De Arcangelis, Gérard Gradwohl   +19 more
doaj   +1 more source

Epidermal growth factor promotes intestinal secretory cell differentiation in weaning piglets via Wnt/β-catenin signalling

Animal, 2020
Small intestinal epithelium homeostasis involves four principal cell types: enterocytes, goblet, enteroendocrine and Paneth cells. Epidermal growth factor (EGF) has been shown to affect enterocyte differentiation.
L.X. Wang, F. Zhu, J.Z. Li, Y.L. Li, X.Q. Ding, J. Yin, X. Xiong, H.S. Yang   +7 more
doaj   +1 more source

Duodenal chemosensory system: enterocytes, enteroendocrine cells, and tuft cells [PDF]

Current Opinion in Gastroenterology, 2020
Purpose of review The gut barrier serves as the primary interface between the environment and host in terms of surface area and complexity. Luminal chemosensing is a term used to describe how small molecules in the gut lumen interact with the host through surface receptors or via transport into the subepithelial space.
Akiba, Yasutada, Hashimoto, Sayuri, Kaunitz, Jonathan   +2 more
openaire   +4 more sources

Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing [PDF]

Current Opinion in Endocrinology, Diabetes & Obesity, 2008
This review discusses the role of enteroendocrine cells of the gastrointestinal tract as chemoreceptors that sense lumen contents and induce changes in gastrointestinal function and food intake through the release of signaling substances acting on a variety of targets locally or at a distance.Recent evidence supports the concept that chemosensing in ...
Catia, Sternini, Laura, Anselmi, Enrique, Rozengurt   +2 more
openaire   +2 more sources

Models and Tools for Studying Enteroendocrine Cells

Endocrinology, 2018
AbstractGut hormones produced by gastrointestinal enteroendocrine cells modulate key physiological processes including glucose homeostasis and food intake, making them potential therapeutic candidates to treat obesity and diabetes. Understanding the function of enteroendocrine cells and the molecular mechanisms driving hormone production is a key step ...
Goldspink, Deborah A, Reimann, Frank, Gribble, Fiona M   +2 more
openaire   +3 more sources

Short Chain Fatty Acids Enhance Expression and Activity of the Umami Taste Receptor in Enteroendocrine Cells via a Gαi/o Pathway

Frontiers in Nutrition, 2020
The short chain fatty acids (SCFAs) acetate, butyrate and propionate, are produced by fermentation of non-digestible carbohydrates by the gut microbiota and regulate appetite, adiposity, metabolism, glycemic control, and immunity.
Matilda Shackley, Matilda Shackley, Yue Ma, Edward W. Tate, Alastair J. H. Brown, Gary Frost, Aylin C. Hanyaloglu   +6 more
doaj   +1 more source

Enteroendocrine cells and appetite dysregulation in Crohn's disease [PDF]

Gut, 2011
Introduction Loss of appetite and malnutrition in active Crohn's disease (CD) are important problems. The biological mechanisms underpinning appetite loss are unclear. Enteroendocrine cells (EEC) form a pivotal part of the brain-gut axis that controls appetite and satiety.
Gordon W. Moran, John McLaughlin
openaire   +1 more source

Glucagon-Like Peptide-2 and the Enteric Nervous System Are Components of Cell-Cell Communication Pathway Regulating Intestinal Na+/Glucose Co-transport

Frontiers in Nutrition, 2018
The Na+/glucose cotransporter 1, SGLT1 is the major route for transport of dietary glucose from the lumen of the intestine into absorptive enterocytes. Sensing of dietary sugars and artificial sweeteners by the sweet taste receptor, T1R2-T1R3, expressed ...
Andrew W. Moran, Miran A. Al-Rammahi, Miran A. Al-Rammahi, Daniel J. Batchelor, David M. Bravo, Soraya P. Shirazi-Beechey   +5 more
doaj   +1 more source

Case Report: Severe Hypocalcemic Episodes Due to Autoimmune Enteropathy

Frontiers in Endocrinology, 2021
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare monogenic disorder, associated with endocrine deficiencies and non-endocrine involvement.
Inbal Halabi, Inbal Halabi, Marie Noufi Barohom, Marie Noufi Barohom, Marie Noufi Barohom, Sarit Peleg, Phillippe Trougouboff, Ghadir Elias-Assad, Ghadir Elias-Assad, Rhania Agbaria, Yardena Tenenbaum-Rakover, Yardena Tenenbaum-Rakover   +11 more
doaj   +1 more source