Results 81 to 90 of about 10,616,742 (287)

Glutamine-induced signaling pathways via amino acid receptors in enteroendocrine L cell line.

Journal of Molecular Endocrinology, 2020
Glucagon-like peptide-1 (GLP-1), secreted by gastrointestinal enteroendocrine L cells, induces insulin secretion and is important for glucose homeostasis. GLP-1 secretion is induced by various luminal nutrients, including amino acids.
Takumi Nakamura, Kazuki Harada, Taichi Kamiya, Mai Takizawa, Jim Küppers, K. Nakajima, M. Gütschow, T. Kitaguchi, K. Ohta, Tadafumi Kato, T. Tsuboi   +10 more
semanticscholar   +1 more source

Gastrointestinal viral load and enteroendocrine cell number are associated with altered survival in HIV-1 infected individuals. [PDF]

PLoS ONE, 2013
Human immunodeficiency virus type 1 (HIV-1) infects and destroys cells of the immune system leading to an overt immune deficiency known as HIV acquired immunodeficiency syndrome (HIV/AIDS).
Guido van Marle, Keith A Sharkey, M John Gill, Deirdre L Church   +3 more
doaj   +1 more source

Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]

, 2018
Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core   +2 more sources

Physiological Gut Oxygenation Alters GLP‐1 Secretion from the Enteroendocrine Cell Line STC‐1

Molecular Nutrition & Food Research, 2018
SCOPE Enteroendocrine cell lines are routinely assayed in simple buffers at ≈20% oxygen to screen foods for bioactives that boost satiety hormone levels.
A. Kondrashina, D. Papkovsky, L. Giblin
semanticscholar   +1 more source

Long-term culture captures injury-repair cycles of colonic stem cells [PDF]

, 2019
The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. The responsive stem cell that mediates this process is unclear, in part because of a lack of in vitro models that recapitulate key ...
Chen, Feidi, Cheng, Jiye, Chiang, I-Ling, Fujii, Satoru, Gordon, Jeffrey I, Han, Nathan D, Janova, Hana, Lai, Chin-Wen, Liu, Ta-Chiang, Lu, Qiuhe, Muegge, Brian D, Ohara, Takahiro E, Sibley, L David, Stappenbeck, Thaddeus S, VanDussen, Kelli L, Ver Heul, Aaron, Wang, Yi, Whitehurst, Charles E, Wu, Renee, Xiong, Shanshan   +19 more
core   +1 more source

A Model of Colonic Crypts using SBML Spatial

, 2013
The Spatial Processes package enables an explicit definition of a spatial environment on top of the normal dynamic modeling SBML capabilities. The possibility of an explicit representation of spatial dynamics increases the representation power of SBML ...
Antoniotti, Marco, Maj, Carlo, Ramazzotti, Daniele   +2 more
core   +2 more sources

Endocrine remodelling of the adult intestine sustains reproduction in Drosophila. [PDF]

, 2015
The production of offspring is energetically costly and relies on incompletely understood mechanisms that generate a positive energy balance. In mothers of many species, changes in key energy-associated internal organs are common yet poorly characterised
Abdou, Al-Anzi, Antonello, Athippozhy, Avila, Bajgar, Barnes, Biteau, Biteau, Bontonou, Buchon, Busson, Carey, Carvalho, Casirola, Cerf, Charles, Choi, Cognigni, David, Economos, Fahrbach, Flatt, Flatt, Flatt, Glinoer, Gore, Gwinn, Hammond, Hansen, Hildebrandt, Horton, Jiang, Jindra, Jindra, Jowett, Keller, Klepsatel, Koren, Koyama, Kubli, Kunte, Langevin, Lee, Lemaitre, Li, Lodhi, Marianes, Marois, McGuire, Micchelli, Middleton, Min, Mirth, Mirth, Moshitzky, Navare, Nijhout, O'Brien, Padmanabha, Palm, Parker, Parra-Peralbo, Phillips, Piersma, R Development Core Team, Rauschenbach, Rera, Riddiford, Roa, Rogina, Ryu, Sarraf-Zadeh, Schneider, Seegmiller, Shimano, Shin, Sieber, Siegmund, Song, Speakman, Theopold, Tiu, Ueyama, Venables, Wen, Wigby, Wyatt, Yamamoto, Yin, Zhang   +90 more
core   +2 more sources

The Elusive S Cells: Reevaluating Enteroendocrine Cell Classification

, 2023
Abstract The nomenclature of enteroendocrine cells (EECs), established in 1977, applies the ”one cell - one hormone” dogma, which distinguishes subpopulations based on the secretion of a specific hormone. These hormone-specific subpopulations include S cells for secretin, K cells for glucose-dependent insulinotropic polypeptide, N cells ...
Martin Klingenspor, Franc Hysenaj, Michael Lauber, Andrea Bast-Habersbrunner, Markus List   +4 more
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Role of Cytolethal Distending Toxin in Altered Stool Form and Bowel Phenotypes in a Rat Model of Post-infectious Irritable Bowel Syndrome. [PDF]

, 2012
Background/aimsCampylobacter jejuni infection is a leading cause of acute gastroenteritis, which is a trigger for post-infectious irritable bowel syndrome (PI-IBS). Cytolethal distending toxin (CDT) is expressed by enteric pathogens that cause PI-IBS. We
Alpern, Joel, Barlow, Gillian M, Chang, Christopher, Hwang, Laura, Jee, Sam-Ryong, Khoshini, Reza, Low, Kimberly, Marsh, Zachary, Morales, Walter, Pimentel, Mark, Pokkunuri, Venkata, Wang, Hanlin, Weitsman, Stacy   +12 more
core   +1 more source