Results 131 to 140 of about 4,441,967 (229)

Modulating the Gut–Ovarian Axis: Mechanistic Rationale and the Limits of Current Evidence for Probiotics in Female Reproductive Aging

open access: yesFood Science &Nutrition, Volume 14, Issue 10, October 2026.
Selected orally administered probiotics and functional‐food interventions may alter gut microbial ecology and intestinal barrier function. Microbiota‐derived metabolites, microbial components, and endocrine signals—including short‐chain fatty acids, bile acids, tryptophan metabolites, and lipopolysaccharide—may influence systemic immune, metabolic, and
Meiqi Chen   +6 more
wiley   +1 more source

Elevated endogenous glucagon‐like peptide‐1 as a novel Alzheimer's disease biomarker associated with neuroinflammation and Aβ pathology

open access: yesGeneral Psychiatry, Volume 39, Issue 5, October 2026.
ABSTRACT Background Alzheimer's disease (AD), a neurodegenerative disorder, is pathologically defined by the accumulation of amyloid‐β (Aβ) plaques, hyperphosphorylated tau tangles and sustained neuroinflammation. Glucagon‐like peptide‐1 (GLP‐1), originally characterised as an incretin hormone, is also expressed endogenously in the brain.
Jianping Li   +12 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Steatohepatitis and the Progression of Cognitive Decline in Older Thai People With HIV

open access: yesJournal of the International AIDS Society, Volume 29, Issue 10, October 2026.
ABSTRACT Introduction Metabolic dysfunction‐associated steatohepatitis (MASH) is more common in people with HIV and associated with systemic inflammation and extrahepatic complications, including cognitive impairment. While cross‐sectional studies suggest an association between MASH and worse cognitive outcomes, its impact on longitudinal cognitive ...
Katekarn Porkaew   +7 more
wiley   +1 more source

Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion

open access: yes, 2007
Enteroendocrine cells are known primarily for their production of hormones that affect digestion, but they might also be implicated in sensing and neutralizing or expelling pathogens.
S. Selleri   +10 more
core   +1 more source

Exclusive enteral nutrition containing transforming growth factor‐β improves intestinal barrier function in a colitis mouse model

open access: yesJournal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 4, Page 692-702, October 2026.
Abstract Objectives Exclusive enteral nutrition (EEN) is the first‐line treatment for pediatric Crohn's disease, but its mechanisms of action remain poorly understood. Our aim was to identify the mechanisms that could explain the anti‐inflammatory effects of EEN, studying the nutritional composition and transforming growth factor‐β (TGF‐β) effects, in ...
Kawthar Boumessid   +6 more
wiley   +1 more source

Gastrointestinal Microbiome Dysbiosis in Cancer Development: Mechanisms and Biomarker Potential

open access: yesMicrobiologyOpen, Volume 15, Issue 5, October 2026.
Dysbiosis of the gastrointestinal microbiome plays a role in carcinogenesis by inducing chronic inflammation, DNA damage, and activation of signaling pathways such as NF‐κB, STAT3, and Wnt/β‐catenin. Microorganisms such as Helicobacter pylori, Fusobacterium nucleatum, and Bacteroides fragilis promote the development of gastrointestinal tumors through ...
Negar Asgari   +2 more
wiley   +1 more source

Organoids: Current Applications and Future Directions

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng   +14 more
wiley   +1 more source

Endoscopic small bowel therapies for type 2 diabetes

open access: yesNutrition in Clinical Practice, Volume 41, Issue 5, Page 1296-1306, October 2026.
Abstract Type 2 diabetes is a global epidemic despite current medical treatments. Many patients are not responsive to medications, and patients with obesity are hesitant about bariatric surgery. Studies investigating the metabolic effects of Roux‐en‐Y gastric bypass have increasingly demonstrated that the duodenum plays a key role in the ...
Roma Patel   +4 more
wiley   +1 more source

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