Results 131 to 140 of about 4,441,967 (229)
Selected orally administered probiotics and functional‐food interventions may alter gut microbial ecology and intestinal barrier function. Microbiota‐derived metabolites, microbial components, and endocrine signals—including short‐chain fatty acids, bile acids, tryptophan metabolites, and lipopolysaccharide—may influence systemic immune, metabolic, and
Meiqi Chen +6 more
wiley +1 more source
Fundamental Neurochemistry Review: The role of enteroendocrine cells in visceral pain. [PDF]
Londregan A +3 more
europepmc +1 more source
ABSTRACT Background Alzheimer's disease (AD), a neurodegenerative disorder, is pathologically defined by the accumulation of amyloid‐β (Aβ) plaques, hyperphosphorylated tau tangles and sustained neuroinflammation. Glucagon‐like peptide‐1 (GLP‐1), originally characterised as an incretin hormone, is also expressed endogenously in the brain.
Jianping Li +12 more
wiley +1 more source
ABSTRACT Introduction Metabolic dysfunction‐associated steatohepatitis (MASH) is more common in people with HIV and associated with systemic inflammation and extrahepatic complications, including cognitive impairment. While cross‐sectional studies suggest an association between MASH and worse cognitive outcomes, its impact on longitudinal cognitive ...
Katekarn Porkaew +7 more
wiley +1 more source
Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion
Enteroendocrine cells are known primarily for their production of hormones that affect digestion, but they might also be implicated in sensing and neutralizing or expelling pathogens.
S. Selleri +10 more
core +1 more source
Abstract Objectives Exclusive enteral nutrition (EEN) is the first‐line treatment for pediatric Crohn's disease, but its mechanisms of action remain poorly understood. Our aim was to identify the mechanisms that could explain the anti‐inflammatory effects of EEN, studying the nutritional composition and transforming growth factor‐β (TGF‐β) effects, in ...
Kawthar Boumessid +6 more
wiley +1 more source
Gastrointestinal Microbiome Dysbiosis in Cancer Development: Mechanisms and Biomarker Potential
Dysbiosis of the gastrointestinal microbiome plays a role in carcinogenesis by inducing chronic inflammation, DNA damage, and activation of signaling pathways such as NF‐κB, STAT3, and Wnt/β‐catenin. Microorganisms such as Helicobacter pylori, Fusobacterium nucleatum, and Bacteroides fragilis promote the development of gastrointestinal tumors through ...
Negar Asgari +2 more
wiley +1 more source
Organoids: Current Applications and Future Directions
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng +14 more
wiley +1 more source
Endoscopic small bowel therapies for type 2 diabetes
Abstract Type 2 diabetes is a global epidemic despite current medical treatments. Many patients are not responsive to medications, and patients with obesity are hesitant about bariatric surgery. Studies investigating the metabolic effects of Roux‐en‐Y gastric bypass have increasingly demonstrated that the duodenum plays a key role in the ...
Roma Patel +4 more
wiley +1 more source

