Results 101 to 110 of about 2,925 (189)
Insights into human norovirus cultivation in human intestinal enteroids
mSphereABSTRACT Human noroviruses (HuNoVs) are a significant cause of epidemic and sporadic acute gastroenteritis worldwide. The lack of a reproducible culture system hindered the study of HuNoV replication and pathogenesis for almost a half-century.
Khalil Ettayebi +15 more
openaire +5 more sources
Regulatory network analysis of Paneth cell and goblet cell enriched gut organoids using transcriptomics approaches [PDF]
, 2020 The epithelial lining of the small intestine consists of multiple cell types, including Paneth cells and goblet cells, that work in cohort to maintain gut health. 3D in vitro cultures of human primary epithelial cells, called organoids, have become a key
Brooks, J +15 more
core +2 more sources
Frontiers in ImmunologyIntroductionThe critical early stages of infection and innate immune responses to porcine epidemic diarrhea virus (PEDV) at the intestinal epithelium remain underexplored due to the limitations of traditional cell culture and animal models.
Lu Yen +6 more
doaj +1 more source
Apical‐out Tubuloids for Accurate Kidney Toxicity Studies
Aggregate, Volume 6, Issue 3, March 2025.Apical‐out tubuloids are developed to study apical drug transport and drug‐induced nephrotoxicity. These tubuloids exhibit primary cilia and relevant structural proteins, indicating apical‐out polarity and enhanced functionality. Functional assays, including bovine serum albumin uptake, confirm their physiological relevance for studying apical ...
Yugyeong Lee +10 more
wiley +1 more source
Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection [PDF]
, 2018 Several viruses induce intestinal epithelial cell death during enteric infection. However, it is unclear whether proapoptotic capacity promotes or inhibits replication in this tissue.
Aravamudhan, Pavithra +12 more
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Mechanisms underlying bone loss associated with gut inflammation [PDF]
, 2019 Patients with gastrointestinal diseases frequently suffer from skeletal abnormality, characterized by reduced bone mineral density, increased fracture risk, and/or joint inflammation.
Abu-Amer, Yousef, Arra, Manoj, Ke, Ke
core +2 more sources
Establishment of a Novel Caco‐2‐Based Cell Culture System for Human Sapovirus Propagation
Genes to Cells, Volume 30, Issue 2, March 2025.We identified that both Caco‐2 cells and in‐house Caco‐2/Cas9 cells are susceptible to human sapovirus (HuSaV) infection. By performing two rounds of single‐cell cloning from Caco‐2/Cas9 cells, we successfully established a highly susceptible cell line, designated as Caco‐2MC.
Yuya Fukuda +7 more
wiley +1 more source
JCI Insight, 2021 Cancer cells reprogram cellular metabolism to maintain adequate nutrient pools to sustain proliferation. Moreover, autophagy is a regulated mechanism to break down dysfunctional cellular components and recycle cellular nutrients. However, the requirement
Samantha N. Devenport +16 more
doaj +1 more source
Metástasis en hueso maxilar superior de adenocarcinoma de esófago: presentación de un caso clínico [PDF]
, 2005 Las metástasis en cavidad oral son lesiones raras que representan aproximadamente el 1% de todas las neoplasias malignas de cavidad oral. Las metástasis orales se localizan en un 80-90% en mandíbula, siendo mas raras en maxilar superior.
Acebal Blanco, Faustino +3 more
core +1 more source
Immunological insights into equine responses against Strongylus vulgaris : Ex vivo studies using equine intestinal organoids and blood mononuclear cells [PDF]
, 2021 Anthelminthic drugs have controlled parasitic infections in veterinary species for decades, but today this use is questioned due to concerns about antimicrobial resistance. For most microorganisms, a feasible alternative is vaccination but for parasites,
Hellman, Stina
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