Results 141 to 150 of about 2,029 (168)

Enteroids for Nutritional Studies

Molecular Nutrition & Food Research, 2019
AbstractNutritional studies are greatly hampered by a paucity of proper models. Previous studies on nutrition have employed conventional cell lines and animal models to gain a better understanding of the field. These models lack certain correlations with human physiological responses, which impede their applications in this field.
Yin, YB (Yuebang), de Jonge, Hugo, Wu, X, Yin, YL   +3 more
openaire   +3 more sources

Establishment of MDR1-knockout human enteroids for pharmaceutical application

Drug Metabolism and Pharmacokinetics, 2023
In the drug development process, it is important to assess the contributions of drug-metabolizing enzymes and/or drug transporters to the intestinal pharmacokinetics of candidate compounds. For such assessments, chemical inhibitors are often used in in vitro systems.
Tatsuya Inui, Ryuga Nomoto, Jumpei Yokota, Tomoki Yamashita, Kentaro Okada, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi   +7 more
openaire   +2 more sources

Generation and Quantitative Imaging of Enteroid Monolayers

2020
The intestinal epithelium is a single layer of cells that plays a critical role in digestion, absorbs nutrients from food, and coordinates the delicate interplay between microbes in the gut lumen and the immune system. Epithelial homeostasis is crucial for maintaining health; disruption of homeostasis results in disorders including inflammatory bowel ...
Laura E, Sanman, Ina W, Chen, Jake M, Bieber, Curtis A, Thorne, Lani F, Wu, Steven J, Altschuler   +5 more
openaire   +2 more sources

Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization [PDF]

Developmental Cell, 2018
The intestinal epithelium maintains a remarkable balance between proliferation and differentiation despite rapid cellular turnover. A central challenge is to elucidate mechanisms required for robust control of tissue renewal.
Curtis A Thorne, Laura E Sanman, Melanie H Cobb   +2 more
exaly   +2 more sources

Translocation across a human enteroid monolayer by zoonotic Streptococcus suis correlates with the presence of Gb3-positive cells

IScience
Summary: Streptococcus suis is a zoonotic pathogen that can cause meningitis and septicaemia. The consumption of undercooked pig products is an important risk factor for zoonotic infections, suggesting an oral route of infection.
Thomas J Roodsant, Constance Schultsz
exaly   +2 more sources

Testing Epithelial Permeability in Fetal Tissue-Derived Enteroids

Journal of Visualized Experiments, 2022
Human fetal tissue-derived enteroids are emerging as a promising in vitro model to study intestinal injuries in preterm infants. Enteroids exhibit polarity, consisting of a lumen with an apical border, tight junctions, and a basolateral outer layer exposed to growth media.
Amelia, Llerena, Shaheda, Urmi, Jahanshah, Amin, Byeong, Cha, Thao Tb, Ho   +4 more
openaire   +2 more sources

Apical-Out Enteroids as an Innovative Model for Necrotizing Enterocolitis

Journal of Surgical Research, 2023
Necrotizing enterocolitis (NEC) is a gastrointestinal disease of premature neonates. We previously validated a NEC enteroid model derived from human infant intestinal tissue. Typical enteroid configuration is basolateral-out (BO) without direct access to the luminal (apical) surface.
Heather Liebe, Camille Schlegel, Xue Cai, Alena Golubkova, Christopher Loerke, Tyler Leiva, Catherine J. Hunter   +6 more
openaire   +2 more sources

Effect of essential amino acids on enteroids: Methionine deprivation suppresses proliferation and affects differentiation in enteroid stem cells

Biochemical and Biophysical Research Communications, 2017
We investigated the effects of essential amino acids on intestinal stem cell proliferation and differentiation using murine small intestinal organoids (enteroids) from the jejunum. By selectively removing individual essential amino acids from culture medium, we found that 24 h of methionine (Met) deprivation markedly suppressed cell proliferation in ...
Yuki, Saito, Ken, Iwatsuki, Hikaru, Hanyu, Natsuki, Maruyama, Eitaro, Aihara, Miki, Tadaishi, Makoto, Shimizu, Kazuo, Kobayashi-Hattori   +7 more
openaire   +2 more sources

[Retroperitoneal enteroid cyst].

Journal de chirurgie, 1976
The author report a case of enteroid retroperitoneal cyst treated by enucleation. Such a lesion raises mainly the problem of histological recognition and embryological interpretation for which there are two possible theories: (1) Uptake, before sealing off of the embryo, of a cell group of endoblastic origin which develops some distance from the ...
J C, Patel, F, Monneins, A, Louvel
openaire   +1 more source

Hyaluronic Acid Stimulated Enterocytic Differentiation of Intestinal Stem Cells and Enhanced Enteroid Grafting on Scaffolds

Biotechnology and Bioprocess Engineering, 2023
Siu Chung Ha, Ya-Hui Tsai, Chao-Ling Yao   +2 more
exaly