Results 111 to 120 of about 9,767 (165)

Glucocorticoids do not cause a clinically relevant elevation in the urine protein-to-creatinine ratio in dogs with inflammatory protein-losing enteropathy

Frontiers in Veterinary Science
ObjectiveThis study aimed to document changes in the urine protein-to-creatinine ratio (UPC) in dogs with inflammatory protein-losing enteropathy (iPLE) undergoing glucocorticoid therapy and with no overt evidence of concurrent renal disease.MethodsDogs ...
Cameron J. Wood, Cameron J. Wood, Peter S. Chapman, Cara Horowitz   +3 more
doaj   +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

Mucosal regulatory and effector T-cell imbalance in CVID-associated enteropathy

Frontiers in Immunology
BackgroundCommon variable immunodeficiency (CVID) frequently presents with gastrointestinal complications, yet the immunopathogenesis of CVID-associated enteropathy remains poorly understood.ObjectiveThis study aimed to investigate intestinal T cell ...
Semra Demir, Nevzat Kahveci, Metin Yusuf Gelmez, Derya Unal, Osman Ozan Yegit, Mehmet Akif Yagli, Zulal İstemihan, Neslihan Berker, Bilger Cavus, Fatih Besisik, Esin Cetin Aktas, Asli Gelincik, Gunnur Deniz   +12 more
doaj   +1 more source

Review Article: Accelerating Coeliac Disease Clinical Trials—Beyond Celiac Meeting With Industry, Academics, Patients and the FDA

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 7, Page 890-896, October 2026.
A 2024 multi‐stakeholder meeting examined how to accelerate coeliac disease drug trials, highlighting key considerations in endpoint selection, symptom–histology alignment and feasibility. Progress requires patient‐centred trials showing symptomatic and intestinal improvement, appropriate gluten challenge, and early regulatory engagement, including ...
Lisa M. Fahey, Robert Anderson, Edwin Liu, Joseph A. Murray, Marie E. Robert, Jocelyn Anne Silvester, Kate Avery, Nelson Cheinquer, Kristie Grebe, Bhargav Tulabandula, Daniel A. Leffler, Beyond Celiac Coalition   +11 more
wiley   +1 more source

Gut Microbiota in NSAID Enteropathy: Current Evidence and Future Perspectives for Therapeutic Strategies

Pharmaceuticals
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed worldwide for their analgesic, antipyretic, and anti-inflammatory properties. However, their long-term use is associated with substantial gastrointestinal (GI) toxicity.
Stefania Piccirelli, Brigida Barberio, Enrico Tettoni, Carla Treppiccione, Edoardo Pezzuto, Elisa Tabbone, Daniele Salvi, Luisa Bertin, Viviana Gerardi, Paola Cesaro, Edoardo Vincenzo Savarino   +10 more
doaj   +1 more source

Review Article: Immune Effector Cell‐Mediated Enterocolitis Following CAR‐T Cell Therapy—Clinical Features, Pathophysiology and Management

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 8, Page 1046-1057, October 2026.
Immune effector cell‐mediated enterocolitis is an emerging complication of CAR‐T therapy. This review summarizes its epidemiology, pathophysiology, diagnosis, endoscopic and histopathologic features, and evidence‐based management, emphasizing early recognition, multidisciplinary intervention, and step‐up therapy.
John A. Damianos, Yi Lin, Zongming Eric Chen, Kenneth J. C. Lim, Navreet M. Chowla   +4 more
wiley   +1 more source

Tufting Enteropathy with EpCAM Mutations in Two Siblings

, 2010
Tufting enteropathy is a rare autosomal recessive disorder presenting with early-onset severe intractable diarrhea. The epithelial cell adhesion molecule gene (EpCAM) has recently been identified as the gene responsible for tufting enteropathy.

core   +1 more source

The effect of feeding on serum concentrations of cobalamin, folate, trypsin‐like immunoreactivity, and pancreatic lipase immunoreactivity in dogs with signs of chronic gastrointestinal disease

Journal of Veterinary Internal Medicine
Background It is unknown if serum concentrations of cobalamin, folate, canine pancreatic lipase immunoreactivity (cPLI), and canine trypsin‐like immunoreactivity (cTLI) obtained postprandially are equivalent to measurements obtained after withholding ...
Ashley Melco, Jessica C. Pritchard, Scott J. Hetzel, Alexander Saver, Joao Pedro Cavasin, Jörg M. Steiner   +5 more
doaj   +1 more source

Coagulation Status Assessment in Dogs with Chronic Enteropathy Using Viscoelastic Point-of-Care Coagulation Monitor

Animals
Canine chronic inflammatory enteropathy (CIE) has been associated with coagulation abnormalities, predisposing affected dogs to a hypercoagulable state and potential thromboembolic events.
María José Marín Lucas, Tim Sparks, Chantal Rosa   +2 more
doaj   +1 more source

Faecal Microbiota Transplantation Reduces Lesion Severity and Medication Use in Canine Atopic Dermatitis: A Randomised, Placebo‐Controlled, Double‐Blinded Clinical Trial

Veterinary Dermatology, Volume 37, Issue 5, Page 735-744, October 2026.
Background: Faecal microbiota transplantation (FMT) is an established therapy for gastrointestinal disease, yet its role in canine atopic dermatitis (cAD) remains unclear. Hypothesis/Objectives: We hypothesised that adjunctive FMT improves clinical severity and reduces symptomatic medication use in dogs with cAD.
Vera Felten, Erin Asley West, Franco Martini, Claude Favrot, Stefan Unterer, Jan Suchodolski, Michael Scharl, Harald Renz, Nina Maria Fischer, Ana Rostaher   +9 more
wiley   +1 more source