Results 91 to 100 of about 10,893 (158)

Precision Antimicrobial Therapy Against Fusobacterium nucleatum Using Bioengineered Probiotics Expressing Guided Antimicrobial Peptides (gAMPs)

Microbial Biotechnology, Volume 18, Issue 12, December 2025.
We engineered a probiotic using Lactococcus lactis that targets Fusobacterium nucleatum, a cancer‐associated microbe, by secreting guided antimicrobial peptides (gAMPs) binding to the FomA porin protein. This approach inhibits biofilms, preserves microbial diversity and provides a precise, microbiome‐sparing alternative to broad‐spectrum antibiotics ...
Ankan Choudhury, Colin Scano, Allison Barton, Christopher M. Kearney, K. Leigh Greathouse   +4 more
wiley   +1 more source

Megasphaera Elesdenii Dysregulates Colon Epithelial Homeostasis, Aggravates Colitis‐Associated Tumorigenesis

Advanced Science, Volume 12, Issue 41, November 6, 2025.
A fecal microbial meta‐analysis reveals that Megasphaera is highly abundant in the Asian population with IBD and CRC. M. elsdenii reshapes colonic immunity by triggering DC cell‐mediated Th1 and Th17 inflammation. M. elsdenii and M. elsdenii‐enriched microbiota exacerbate colonic inflammation and tumorigenesis in AOM/DSS mice.
Xinxin Hou, Zhaozhou Zhang, Wanqing Chen, Jinming Li, Xiangxiang Zhu, Mingjie Li, Xiaoqi Guan, Haidong Guo, Yanlei Ma, Ling Zhao   +9 more
wiley   +1 more source

Applications of bacteriophages in precision engineering of the human gut microbiome

Engineering Microbiology
As our understanding of the role of the gut microbiome in human diseases deepens, precision engineering of the gut microbiome using bacteriophages has gained significant attention.
Xiaoxian Kuang, Juntao Shen, Linggang Zheng, Yi Duan, Yingfei Ma, Elaine Lai-Han Leung, Lei Dai   +6 more
doaj   +1 more source

The association between fecal enterotoxigenic B. fragilis with colorectal cancer

BMC Cancer, 2019
Background Enterotoxigenic Bacteroides fragilis (ETBF) is an enterotoxin-producing bacterium that possibily has a role in the occurrence and progression of colorectal cancer (CRC) by modulating the mucosal immune response and inducing epithelial cell ...
Fakhri Haghi, Elshan Goli, Bahman Mirzaei, Habib Zeighami   +3 more
doaj   +1 more source

The Intestinal Microbiota and Colorectal Cancer

Frontiers in Immunology, 2020
The intestinal microbiota, composed of a large population of microorganisms, is often considered a “forgotten organ” in human health and diseases. Increasing evidence indicates that dysbiosis of the intestinal microbiota is closely related to colorectal ...
Yiwen Cheng, Zongxin Ling, Lanjuan Li
doaj   +1 more source

Postbiotic from Lactobacillus acidophilus Inhibits Ferroptosis in Intestinal Stem Cells via Microbiota–AhR Axis to Mitigate Colitis

Food Frontiers, Volume 6, Issue 6, Page 2975-2993, November 2025.
Lacidophilin tablets alleviate colitis by regulating gut microbiota balance and maintaining intestinal barrier integrity. ABSTRACT Inflammatory bowel disease (IBD) is a chronic, progressive intestinal disorder. Dysbiosis of the gut microbiota is strongly implicated in the onset and progression of IBD.
Denglong Sun, Chenxuan Wang, Qigui Fan, Yang Zhan, Xiaoying Cheng, Jingwen Zhang, Qinxin Wang, Yingmeng Li, Qiong Li, Yanxia Xiong, Wenjun Liu   +10 more
wiley   +1 more source

Quantitative Profiling of Colorectal Cancer-Associated Bacteria Reveals Associations between Fusobacterium spp., Enterotoxigenic Bacteroides fragilis (ETBF) and Clinicopathological Features of Colorectal Cancer

PLoS ONE, 2015
Various studies have presented clinical or in vitro evidence linking bacteria to colorectal cancer, but these bacteria have not previously been concurrently quantified by qPCR in a single cohort.
Katie S Viljoen, A. Dakshinamurthy, P. Goldberg, J. Blackburn   +3 more
semanticscholar   +1 more source

Gut Virome: What's the Role in Irritable Bowel Syndrome?

Reviews in Medical Virology, Volume 35, Issue 6, November 2025.
ABSTRACT The gut virome, an integral but still poorly understood component of the gut microbiota, is emerging as an important player in the pathophysiology of irritable bowel syndrome (IBS). Recent evidence suggests that alterations in virome diversity and phage–bacteria interactions contribute to gut dysbiosis, immune modulation and gut barrier ...
Francesco Rettura, Christian Lambiase, Andrea Bottari, Fabio Filippini, Luca Giacomelli, Mauro Pistello, Massimo Bellini   +6 more
wiley   +1 more source

A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues

Nature Communications
Efficient interbacterial competitions and diverse defensive strategies employed by various bacteria play a crucial role in acquiring a hold within a dense microbial community.
Ming Tong, Jinghua Xu, Weixun Li, Kun Jiang, Yan Yang, Zhe Chen, Xuyao Jiao, Xiangfeng Meng, Mingyu Wang, Jie Hong, Hongan Long, Shuang-Jiang Liu, Bentley Lim, Xiang Gao   +13 more
doaj   +1 more source

Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin

Frontiers in Cellular and Infection Microbiology, 2019
Objective: The human intestinal microbiome plays an important role in inflammatory bowel disease (IBD) and colorectal cancer (CRC) development. One of the first discovered bacterial mediators involves Bacteroides fragilis toxin (BFT, also named as ...
Paul Metz, Paul Metz, Paul Metz, Martijn J. H. Tjan, Martijn J. H. Tjan, Shaoguang Wu, Mehrosh Pervaiz, Susanne Hermans, Aishwarya Shettigar, Cynthia L. Sears, Tina Ritschel, Bas E. Dutilh, Bas E. Dutilh, Annemarie Boleij   +13 more
doaj   +1 more source