Results 101 to 110 of about 10,893 (158)

The tumor–microbe connection

Molecular Oncology, Volume 19, Issue 10, Page 2753-2757, October 2025.
Tumor‐associated bacteria (TAB) dynamically influence cancer biology by modulating tumor progression, metastatic spread, and therapeutic efficacy. Their presence redefines the tumor microenvironment (TME) as a microbial–host interface, yet mechanistic insights remain limited. Understanding TAB colonization routes, functional impacts, and crosstalk with
Gerlanda Vella, Maria Rescigno
wiley   +1 more source

The Ambivalent Nature of Bacteroides fragilis and the Interaction with Clostridioides difficile: Benefits and Disadvantages for the Human Host

Toxins
Bacteroides fragilis is a usually beneficial colonizer of the human gut that can also act as an opportunistic pathogen, causing infection and contributing to the development and progression of important diseases.
Patrizia Spigaglia
doaj   +1 more source

The microbiome in cancer

iMeta, Volume 4, Issue 5, October 2025.
This comprehensive review elucidates the transformative role of the human microbiome in cancer biology, revealing innovative mechanistic insights into the intricate tumor–microbe interactions across diverse organ systems. This work highlights the clinical and translational value of novel microbiome‐based biomarkers for early detection, prognosis, and ...
Anqi Lin, Minying Xiong, Aimin Jiang, Lihaoyun Huang, Hank Z. H. Wong, Suyin Feng, Chunyan Zhang, Yu Li, Li Chen, Hao Chi, Pengpeng Zhang, Bicheng Ye, Hengguo Zhang, Nan Zhang, Lingxuan Zhu, Weiming Mou, Junyi Shen, Kailai Li, Wentao Xu, Haoxuan Ying, Cangang Zhang, Dongqiang Zeng, Jindong Xie, Xinpei Deng, Qi Wang, Jianying Xu, Wenjie Shi, Chang Qi, Chunrun Qu, Xufeng Huang, András Hajdu, Chaoqun Li, Changmin Peng, Xuanye Cao, Guangsheng Pei, Lin Zhang, Yujia Huo, Jiabao Xu, Antonino Glaviano, Attila Gábor Szöllősi, Sicheng Bian, Zhengrui Li, Hailin Tang, Bufu Tang, Zaoqu Liu, Jian Zhang, Kai Miao, Quan Cheng, Ting Wei, Shuofeng Yuan, Peng Luo   +50 more
wiley   +1 more source

Outer Membrane Vesicles From Bacteroides fragilis Contain Coding and Non‐Coding Small RNA Species That Modulate Inflammatory Signalling in Intestinal Epithelial Cells

Journal of Extracellular Biology, Volume 4, Issue 10, October 2025.
Outer membrane vesicles (OMVs) from Bacteroides fragilis carry distinct coding and non‐coding RNAs that influence host inflammatory signaling. Extravesicular RNAs from OMVs suppress IL‐8 expression in intestinal epithelial cells, while removal of these RNAs enhances pro‐inflammatory IL‐8 responses.
Aadil Sheikh, Colin Scano, Julia Xu, Tolulope Ojo, Jessica M. Conforti, Kayla L. Haberman, Bryan King, Alysia S. Martinez, Michelle Pujol, Juli Watkins, James Lotter, Emily L. Lin, Bernd Zechmann, Amanda Sevcik, Christie Sayes, Elyssia S. Gallagher, Steven P. Lang, Joshua Mell, Garth D. Ehrlich, Joseph H. Taube, K. Leigh Greathouse   +20 more
wiley   +1 more source

Bacteroides Fragilis‐Derived Outer Membrane Vesicles Deliver MiR‐5119 and Alleviate Colitis by Targeting PD‐L1 to Inhibit GSDMD‐Mediated Neutrophil Extracellular Trap Formation

Advanced Science, Volume 12, Issue 35, September 18, 2025.
Bacteroides fragilis‐derived outer membrane vesicles deliver miR‐5119 and alleviate colitis by targeting PD‐L1 to inhibit GSDMD‐mediated neutrophil extracellular trap formation. Abstract Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system.
Yi Yang, Lanmengxi Yang, Yilin Yang, Haiyi Deng, Shiyu Su, Yinxiao Xia, Jin Su, Yuheng Liu, Junwei Wu, Jing Zhang, Yao Liao, Lifu Wang   +11 more
wiley   +1 more source

Influence of Citrobacter freundii on NINJ2 Expression and Oxaliplatin Resistance in Colorectal Cancer

Cancer Medicine, Volume 14, Issue 13, July 2025.
Oxaliplatin resistance was found to be induced in colon cancer cells by bacterial filtrates from Citrobacter freundii. This resistance was associated with downregulation of the NINJ2 gene, which was found to suppress apoptosis and reactive oxygen species.
Reio Ueta, Hiroo Imai, Ken Saijo, Yoshifumi Kawamura, Shuto Kodera, Chikashi Ishioka   +5 more
wiley   +1 more source

[Selected properties of Bacteroides fragilis enterotoxigenic strains].

Medycyna doswiadczalna i mikrobiologia, 1996
Seven B. fragilis strains were examined. One strain was reference, non-enterotoxigenic, representing serotype E2 according to Beerens et al. (1971). Six strains produced enterotoxin (ETBF). Four of them were isolated from human feces and two of them from swine feces.
A, Rokosz, F, Meisel-Mikołajczyk
openaire   +1 more source

Bacteroides fragilis Toxin Induces Sequential Proteolysis of E-Cadherin and Inflammatory Response in Mouse Intestinal Epithelial Cell Line

Microorganisms
Enterotoxigenic Bacteroides fragilis (ETBF) is an intestinal bacterium that secretes the metalloprotease Bacteroides fragilis toxin (BFT), which induces E-cadherin cleavage and interleukin-8 secretion in human intestinal epithelial cell lines.
Woo-Seung Kim, Soonjae Hwang, Sun-Yeong Gwon, Minjeong Jo, Sang-Hyeon Yoo, Jiyun Hong, Ha-Neul Jang, Ju-Eun Hong, Da-Hye Kang, Miyong Yun, Ki-Jong Rhee   +10 more
doaj   +1 more source

Zerumbone Suppresses Enterotoxigenic Bacteroides fragilis Infection-Induced Colonic Inflammation through Inhibition of NF-κΒ

International Journal of Molecular Sciences, 2019
Enterotoxigenic Bacteroides fragilis (ETBF) is human intestinal commensal bacterium and a potent initiator of colitis through secretion of the metalloprotease Bacteroides fragilis toxin (BFT).
Soonjae Hwang, Minjeong Jo, J. Hong, Chan Oh Park, C. Lee, Miyong Yun, Ki-Jong Rhee   +6 more
semanticscholar   +1 more source

Microplastics and the Rising Tide of Early‐Onset Colorectal Cancer: Exploring the Environmental Gut Connection

ANZ Journal of Surgery, Volume 95, Issue 10, Page 1982-1985, October 2025.
Rathin Gosavi, Wye‐Khay Fong, Raymond Yap, Stephen Bell, Geraldine Ooi, Vignesh Narasimhan   +5 more
wiley   +1 more source