Results 81 to 90 of about 10,893 (158)

The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice

iScience, 2023
Summary: The gut microbiota in early childhood is linked to asthma risk, but may continue to affect older patients with asthma. Here, we profile the gut microbiota of 38 children (19 asthma, median age 8) and 57 adults (17 asthma, median age 28) by 16S ...
Naomi G. Wilson, Ariel Hernandez-Leyva, Anne L. Rosen, Natalia Jaeger, Ryan T. McDonough, Jesus Santiago-Borges, Michael A. Lint, Thomas R. Rosen, Christopher P. Tomera, Leonard B. Bacharier, S. Joshua Swamidass, Andrew L. Kau   +11 more
doaj   +1 more source

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
Centralizes the microbiome within 3D tumor‐microbiome model platforms, including spheroids, organoids, 3D‐bioprinted constructs, and microfluidic chips, each enabling structured host‐tumor‐microbe studies. These systems support bacterial colonization, facilitating investigation of microbial impacts on tumor growth, immunity, and therapy. The microbiome
Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky, Opal Avramoff, Anshika Katyal, Koren Salomon, Adan Miari, Dana Venkert, Tania T. Barnatan, América García Alvarado, Shahar Greenberg, Ronit Satchi‐Fainaro   +12 more
wiley   +1 more source

Diversity of the Metalloprotease Toxin Produced by Enterotoxigenic Bacteroides fragilis [PDF]

Infection and Immunity, 2002
ABSTRACT Enterotoxigenic Bacteroides fragilis (ETBF) strains produce a 20-kDa zinc metalloprotease toxin (BFT) associated with diarrheal disease of animals, young children, and adults. BFT stimulates secretion in intestinal loops in vivo and modifies epithelial cell morphology in vitro.
Shaoguang, Wu, Lawrence A, Dreyfus, Art O, Tzianabos, Chika, Hayashi, Cynthia L, Sears   +4 more
openaire   +2 more sources

Progress in the detection of gut microbiota based on microfluidic technology

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
Abstract Gut microbiota, a complex microbial community in the human intestine, are vital for digestion, nutrient absorption, and immune regulation, maintaining gut micro‐ecological balance. Accurate detection of its composition, structure, and function is crucial for understanding the relationship between health and disease, early disease diagnosis ...
Yuan Tan, Jiayue Huang, Yi Liu, Xiaofei Lai   +3 more
wiley   +1 more source

Gut colonization with an obesity-associated enteropathogenic microbe modulates the premetastatic niches to promote breast cancer lung and liver metastasis

Frontiers in Immunology, 2023
IntroductionObesity, an independent risk factor for breast cancer growth and metastatic progression, is also closely intertwined with gut dysbiosis; and both obese state and dysbiosis promote each other.
Sheetal Parida, Sumit Siddharth, Himavanth R. Gatla, Shaoguang Wu, Guannan Wang, Guannan Wang, Kathleen Gabrielson, Kathleen Gabrielson, Cynthia L. Sears, Cynthia L. Sears, Cynthia L. Sears, Brian H. Ladle, Brian H. Ladle, Dipali Sharma   +13 more
doaj   +1 more source

Identification of enterotoxigenic Bacteroides fragilis in patients with diarrhea: A study targeting 16S rRNA, gyrB and nanH genes.

Anaerobe, 2021
OBJECTIVES We aimed to identify the enterotoxigenic Bacteroides fragilis (ETBF) and bft subtypes among patients with diarrhea. In addition, we assessed whether DNA gyrase subunit B (gyrB) and neuraminidase (nanH) genes are useful determinants for ...
Rosa Amiri, Zahra Norouzbabaei, Naeemeh Kalali, S. Ghourchian, M. Yaseri, A. Abdollahi, M. Douraghi   +6 more
semanticscholar   +1 more source

The interplay between tissue‐resident microbiome and host proteins by integrated multi‐omics during progression of colorectal adenoma to carcinoma

iMeta, Volume 4, Issue 6, December 2025.
This study integrated metagenomic and proteomic profiling of 185 colorectal tissue samples—spanning adenoma (A), tumor (T), and para‐tumor (P)—to characterize multi‐kingdom microbiome and host protein dynamics in colorectal cancer (CRC). In total, 4057 bacterial, 61 fungal, 108 archaeal, and 374 viral species were identified, revealing CRC‐specific ...
Di Wu, An‐Jun Wang, De‐Chao Bu, Yan‐Yan Sun, Chen‐Hao Li, Yue‐Mei Hong, Shan Zhang, Shi‐Yang Chen, Jin‐An Zhou, Tian‐Yi Zhang, Min‐Hao Yu, Yong‐Jing Ma, Xiu‐Li Wang, Jia Xu, Wei He, Christopher Heeschen, Jian‐Feng Chen, Wen‐Jun Mao, Hui Ding, Wen‐Juan Wu, Yi Zhao, Hui Wang, Ning‐Ning Liu   +22 more
wiley   +1 more source

Polyamine catabolism contributes to enterotoxigenicBacteroides fragilis-induced colon tumorigenesis [PDF]

Proceedings of the National Academy of Sciences, 2011
It is estimated that the etiology of 20–30% of epithelial cancers is directly associated with inflammation, although the direct molecular events linking inflammation and carcinogenesis are poorly defined. In the context of gastrointestinal disease, the bacterium enterotoxigenicBacteroides fragilis(ETBF) is a significant source of chronic inflammation ...
Andrew C, Goodwin, Christina E, Destefano Shields, Shaoguang, Wu, David L, Huso, XinQun, Wu, Tracy R, Murray-Stewart, Amy, Hacker-Prietz, Shervin, Rabizadeh, Patrick M, Woster, Cynthia L, Sears, Robert A, Casero   +10 more
openaire   +2 more sources

Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer

Frontiers in Cellular and Infection Microbiology, 2022
Although a dysfunctional gut microbiome is strongly linked to colorectal cancer (CRC), our knowledge of the mediators between CRC and the microbiome is limited.
Juan Xing, Yiqun Liao, Huan Zhang, Wenjie Zhang, Zhilin Zhang, Jie Zhang, Daorong Wang, Dong Tang   +7 more
doaj   +1 more source

Protective Effects of Zerumbone on Colonic Tumorigenesis in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized AOM/DSS BALB/c Mice

International Journal of Molecular Sciences, 2020
Chronic inflammation has been linked to colitis-associated colorectal cancer in humans. The human symbiont enterotoxigenic Bacteroides fragilis (ETBF), a pro-carcinogenic bacterium, has the potential to initiate and/or promote colorectal cancer ...
Soonjae Hwang, Minjeong Jo, J. Hong, Chan Oh Park, C. Lee, Ki-Jong Rhee   +5 more
semanticscholar   +1 more source