Results 11 to 20 of about 94,987 (195)

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

bioRxiv, 2020
The main protease of coronaviruses and the 3C protease of enteroviruses share a similar active-site architecture and a unique requirement for glutamine in the P1 position of the substrate.
Linlin Zhang, Daizong Lin, Y. Kusov, Yong Nian, Q. Ma, Jiang Wang, A. von Brunn, P. Leyssen, Kristina Lanko, J. Neyts, Adriaan H. de Wilde, E. Snijder, Hong Liu, R. Hilgenfeld   +13 more
semanticscholar   +1 more source

Antivirals and vaccines for Enterovirus A71 [PDF]

Journal of Biomedical Sciences, 2019
Enterovirus A71 (EV-A71) is an important emerging virus posing a threat to children under five years old. EV-A71 infection in infants or young children can cause hand-foot-and-mouth disease, herpangina, or severe neurological complications.
Jing‐Yi Lin, Yu-An Kung, Shin‐Ru Shih   +2 more
openalex   +2 more sources

Decreased incidence of enterovirus and norovirus infections during the COVID-19 pandemic, Victoria, Australia, 2020.

Communicable diseases intelligence, 2021
Significant reductions in the incidence of enteroviruses and noroviruses, both transmitted primarily by the faecal-oral route, were noted in 2020 compared to the previous decade, in Victoria, Australia.
L. Bruggink, Arnau Garcia-Clapes, T. Tran, J. Druce, B. Thorley   +4 more
semanticscholar   +1 more source

Susceptibility and cytokine responses of human neuronal cells to multiple circulating EV-A71 genotypes in India

Scientific Reports, 2021
Enterovirus-A71 (EV-A71) associated Hand, foot and mouth disease (HFMD) is a highly contagious viral infection affecting children in Asia–Pacific region and has become a major threat to public health.
Madhu Chhanda Mohanty, Swapnil Yashavant Varose, Vinay Kumar Saxena   +2 more
doaj   +1 more source

Impact of Wearing Masks, Hand Hygiene, and Social Distancing on Influenza, Enterovirus, and All-Cause Pneumonia During the Coronavirus Pandemic: Retrospective National Epidemiological Surveillance Study

Journal of Medical Internet Research, 2020
Background The coronavirus disease (COVID-19) pandemic is an important health crisis worldwide. Several strategies were implemented to combat COVID-19, including wearing masks, hand hygiene, and social distancing.
N. Chiu, H. Chi, Yu-Lin Tai, C. Peng, C. Tseng, Chung-Chu Chen, B. Tan, Chien-Yu Lin   +7 more
semanticscholar   +1 more source

Enterovirus A71 Vaccines

Vaccines, 2021
Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) and herpangina. Moreover, EV-A71 infection can lead to neurological complications and death.
Mei-Ling Li, S. Shih, B. Tolbert, G. Brewer   +3 more
semanticscholar   +1 more source

The pathogenesis and virulence of enterovirus-D68 infection

Virulence, 2021
In 2014, enterovirus D68 (EV-D68) emerged causing outbreaks of severe respiratory disease in children worldwide. In a subset of patients, EV-D68 infection was associated with the development of central nervous system (CNS) complications, including acute ...
Syriam Sooksawasdi Na Ayudhya, B. Laksono, D. van Riel   +2 more
semanticscholar   +1 more source

Epidemiological aspects of enterovirus infection in the Russian Federation during the period of 2018–2019

Журнал инфектологии, 2021
Aim: Analysis of enterovirus infection morbidity and characteristics of the etiological agents of this infection on some territories of Russia in 2017.Materials and methods: We investigated 7858 samples of the biological material from the patients ...
N. I. Romanenkova, N. R. Rozaeva, M. A. Bichurina, O. I. Kanaeva, I. G. Chkhyndzheriya, L. V. Shishkina, A. G. Madoyan, N. V. Valdaitseva   +7 more
doaj   +1 more source

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Viruses, 2020
Flavonoids are natural biomolecules that are known to be effective antivirals. These biomolecules can act at different stages of viral infection, particularly at the molecular level to inhibit viral growth.
S. Lalani, C. Poh
semanticscholar   +1 more source

Enteroviruses in Respiratory Samples from Paediatric Patients of a Tertiary Care Hospital in Germany

Viruses, 2021
Enteroviruses are associated with various diseases accompanied by rare but severe complications. In recent years, outbreaks of enterovirus D68 and enterovirus A71 associated with severe respiratory infections and neurological complications have been ...
Susanne Baertl, Corinna Pietsch, Melanie Maier, Mario Hönemann, Sandra Bergs, Uwe G. Liebert   +5 more
doaj   +1 more source