Results 31 to 40 of about 28,174 (173)

VP1 of Enterovirus 71 Protects Mice Against Enterovirus 71 and Coxsackievirus B3 in Lethal Challenge Experiment

open access: yesFrontiers in Immunology, 2019
Enterovirus and Coxsackievirus are the major viruses that cause hand, foot, and mouth disease (HFMD) outbreaks worldwide. Several studies have shown the potential of viral envelope protein 1 (VP1) on providing protective effects from viral strains of ...
Fang-Hong Chen   +12 more
doaj   +1 more source

Neurologic Complications of Enterovirus 71 Infection

open access: yesPediatric Neurology Briefs, 1999
The neurologic complications associated with the 1998 Taiwan enterovirus 71 epidemic are reported from National Cheng Kung University, Tainan; Chang Gung Children’s Hospital, Kaohsiung; and National Defense Medical Center, Taipei, Taiwan.
J Gordon Millichap
doaj   +1 more source

Enterovirus 71 CNS Infection and ADHD

open access: yesPediatric Neurology Briefs, 2008
ADHD symptoms as long-term sequelae of virus-confirmed enterovirus 71 infection were evaluated in 86 children, aged 4 to 16 years, followed at National Taiwan University Hospital, Taipei, and Chang Gung Children’s Hospital, Taoyuan, Taiwan.
J Gordon Millichap
doaj   +1 more source

Crystal Structure of Human Enterovirus 71 [PDF]

open access: yesScience, 2012
The structure of a virus linked to neurological disease reveals how drugs targeting viruses in this family can be modified.
Pavel, Plevka   +4 more
openaire   +2 more sources

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

open access: yesAdvanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng   +9 more
wiley   +1 more source

Excellent Response to Plasma Exchange in Three Patients With Enterovirus-71 Neurological Disease

open access: yesFrontiers in Neurology, 2019
The clinical spectrum of Enterovirus-71-associated neurological disease includes acute flaccid paralysis, encephalomyelitis, or brainstem encephalitis with autonomic dysfunction.
Elba Pascual-Goñi   +8 more
doaj   +1 more source

The infection mechanism of enterovirus 71

open access: yesUirusu, 2012
Identification of a specific viral receptor is important for understanding the virus infection mechanism. I identified P-selectin glycoprotein ligand-1 (PSGL-1) as one of the functional receptors for enterovirus 71 (EV71), a pathogen that causes hand, foot, and mouth disease.
openaire   +3 more sources

Host Factors in Enterovirus 71 Replication [PDF]

open access: yesJournal of Virology, 2011
ABSTRACT Enterovirus 71 (EV71) infections continue to remain an important public health problem around the world, especially in the Asia-Pacific region. There is a significant mortality rate following such infections, and there is neither any proven therapy nor a vaccine for EV71.
Shin-Ru, Shih   +2 more
openaire   +2 more sources

First isolation of enterovirus 71 (EV-71) from Northern Brazil

open access: yesBrazilian Journal of Infectious Diseases
Enterovirus 71 (EV-71) has been associated to cases of neurological disease in many countries including Brazil. This virus has now been reported from three of the five Brazilian regions.
Leticia Martins Lamarão   +2 more
doaj   +1 more source

Continuous veno-venous hemofiltration for treatment of enterovirus 71-induced fulminant cardiopulmonary failure: a case report

open access: yesJournal of Medical Case Reports, 2012
Introduction Fulminant cardiopulmonary failure is a severe complication of hand, foot and mouth diseases due to enterovirus 71 infection, with a high mortality rate. The treatment is mainly supportive with aggressive cardiopulmonary resuscitation.
Phan Phuc   +6 more
doaj   +1 more source

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