Results 1 to 10 of about 5,966,929 (265)

Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models

iScience, 2021
Summary: Nonconvulsive epileptiform activity and microglial alterations have been detected in people with Alzheimer’s disease (AD) and related mouse models. However, the relationship between these abnormalities remains to be elucidated.
Melanie Das, Wenjie Mao, Eric Shao, Soniya Tamhankar, Gui-Qiu Yu, Xinxing Yu, Kaitlyn Ho, Xin Wang, Jiaming Wang, Lennart Mucke   +9 more
doaj   +1 more source

Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by inhibition of BACE1

Molecular Neurodegeneration, 2020
Background Alzheimer’s disease (AD) is the most frequent and costly neurodegenerative disorder. Although diverse lines of evidence suggest that the amyloid precursor protein (APP) is involved in its causation, the precise mechanisms remain unknown and no
Erik C. B. Johnson, Kaitlyn Ho, Gui-Qiu Yu, Melanie Das, Pascal E. Sanchez, Biljana Djukic, Isabel Lopez, Xinxing Yu, Michael Gill, Weiping Zhang, Jeanne T. Paz, Jorge J. Palop, Lennart Mucke   +12 more
doaj   +1 more source

Patients with gastroenteric tumor after upper abdominal surgery were more likely to require rescue analgesia than lower abdominal surgery

BMC Anesthesiology, 2022
Objectives To find out the reasons why patients still need to use rescue analgesics frequently after gastrointestinal tumor surgery under the patient-controlled intravenous analgesia (IV-PCA), and the different abdominal surgery patients using the ...
Ting-Ting Li, Quan-Yuan Chang, Liu-Lin Xiong, Yan-Jun Chen, Qi-Jun Li, Fei Liu, Ting-Hua Wang   +6 more
doaj   +1 more source

Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

Molecular Neurodegeneration, 2017
Background Hyperexcitability of neuronal networks can lead to excessive release of the excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by overactivating NMDA-type glutamate receptors and related signaling pathways.
Takashi Miyamoto, Liana Stein, Reuben Thomas, Biljana Djukic, Praveen Taneja, Joseph Knox, Keith Vossel, Lennart Mucke   +7 more
doaj   +1 more source

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

Molecular Neurodegeneration, 2019
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Ramsey Najm, Emily A. Jones, Yadong Huang   +2 more
doaj   +1 more source

DPYSL2 is a novel regulator for neural stem cell differentiation in rats: revealed by Panax notoginseng saponin administration

Stem Cell Research & Therapy, 2020
Background The limited neuronal differentiation of the endogenous or grafted neural stem cells (NSCs) after brain injury hampers the clinic usage of NSCs.
Liu-Lin Xiong, De-Lu Qiu, Guang-Hui Xiu, Mohammed Al-Hawwas, Ya Jiang, You-Cui Wang, Yue Hu, Li Chen, Qing-Jie Xia, Ting-Hua Wang   +9 more
doaj   +1 more source

High-salt diet downregulates TREM2 expression and blunts efferocytosis of macrophages after acute ischemic stroke

Journal of Neuroinflammation, 2021
Background A high-salt diet (HSD) is one of the major risk factors for acute ischemic stroke (AIS). As a potential mechanism, surplus salt intake primes macrophages towards a proinflammatory phenotype.
Mengyan Hu, Yinyao Lin, Xuejiao Men, Shisi Wang, Xiaobo Sun, Qiang Zhu, Danli Lu, Sanxin Liu, Bingjun Zhang, Wei Cai, Zhengqi Lu   +10 more
doaj   +1 more source

Sarcopenia is associated with non-motor symptoms in Han Chinese patients with Parkinson's Disease: a cross-sectional study

BMC Geriatrics, 2023
Background Sarcopenia is commonly seen in the older adults and increases in incidence with age, also in Parkinson’s disease (PD). Although research has indicated that the development of sarcopenia in patients with PD may be related to both motor symptoms
Qiu-Wan Liu, Cheng-Jie Mao, Zhao-Hui Lu, Rong-Fang Shi, Ying-Chun Zhang, Ping Zhao, Chun-Feng Liu   +6 more
doaj   +1 more source

Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation/inhibition ratios, and counteracts network hypersynchrony

Cell Reports, 2021
Summary: The protein tau has been implicated in many brain disorders. In animal models, tau reduction suppresses epileptogenesis of diverse causes and ameliorates synaptic and behavioral abnormalities in various conditions associated with excessive ...
Che-Wei Chang, Mark D. Evans, Xinxing Yu, Gui-Qiu Yu, Lennart Mucke   +4 more
doaj   +1 more source

Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice

Communications Biology, 2021
Anton Malkov, Irina Popova et al. demonstrate that beta-amyloid application induces oxidative stress and reduces glucose consumption in the mouse brain, leading to network hyperactivity and behavioral changes—pathologies similar to those observed early ...
Anton Malkov, Irina Popova, Anton Ivanov, Sung-Soo Jang, Seo Yeon Yoon, Alexander Osypov, Yadong Huang, Yuri Zilberter, Misha Zilberter   +8 more
doaj   +1 more source