Results 21 to 30 of about 5,966,929 (265)

Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy

Molecular Neurodegeneration, 2023
Background Alzheimer Disease (AD) and cerebral amyloid angiopathy (CAA) are both characterized by amyloid-β (Aβ) accumulation in the brain, although Aβ deposits mostly in the brain parenchyma in AD and in the cerebrovasculature in CAA.
Monica Xiong, Chao Wang, Maud Gratuze, Fareeha Saadi, Xin Bao, Megan E. Bosch, Choonghee Lee, Hong Jiang, Javier Remolina Serrano, Ernesto R. Gonzales, Michal Kipnis, David M. Holtzman   +11 more
doaj   +1 more source

Scaling up services for mental and neurological disorders in low-resource settings. [PDF]

, 2009
Mental and neurological disorders (MNDs) account for a large, and growing, burden of disease in low- and middle-income countries. Most people do not have access to even basic health care for these disorders.
Vikram Patel, Desai, Rajnanda, Patel, Vikram, Goel, Digvijay Singh, Digvijay Singh Goel, Rajnanda Desai   +5 more
core   +2 more sources

Neurological diseases of rabbits and rodents

, 2015
Clinical signs of neurological disease, such as head tilt, hind limb paresis or paralysis, seizures, and muscle weakness, are commonly encountered in pet rabbits, and in the authors׳ experience, less often in rodent species.
Meredith, Anna L., Richardson, Jenna
core   +1 more source

Phosphorylation of Extracellular Signal-Regulated Kinase after Transient Cerebral Ischemia in Hyperglycemic Rats

Neurobiology of Disease, 2001
The present study was undertaken to investigate whether extracellular signal-regulated kinase (ERK) was involved in mediating hyperglycemia-exaggerated cerebral ischemic damage. Phosphorylation of ERK 1/2 was studied by immunocytochemistry and by Western
Ping-An Li, Qing Ping He, Ouyang Yi-Bing, Bing Ren Hu, Bo K. Siesjö   +4 more
doaj   +1 more source

Istradefylline reduces memory deficits in aging mice with amyloid pathology

Neurobiology of Disease, 2018
Adenosine A2A receptors are putative therapeutic targets for neurological disorders. The adenosine A2A receptor antagonist istradefylline is approved in Japan for Parkinson's disease and is being tested in clinical trials for this condition elsewhere ...
Anna G. Orr, Iris Lo, Heike Schumacher, Kaitlyn Ho, Michael Gill, Weikun Guo, Daniel H. Kim, Anthony Knox, Takashi Saito, Takaomi C. Saido, Jeffrey Simms, Carlee Toddes, Xin Wang, Gui-Qiu Yu, Lennart Mucke   +14 more
doaj   +1 more source

Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model

Nature Communications, 2023
Accumulation of amyloid beta protein (Aβ) in brain vessels damages blood brain barrier (BBB) integrity in cerebral amyloid angiopathy (CAA). Macrophage lineage cells scavenge Aβ and produce disease-modifying mediators. Herein, we report that Aβ40-induced
Mengyan Hu, Tiemei Li, Xiaomeng Ma, Sanxin Liu, Chunyi Li, Zhenchao Huang, Yinyao Lin, Ruizhen Wu, Shisi Wang, Danli Lu, Tingting Lu, Xuejiao Men, Shishi Shen, Huipeng Huang, Yuxin Liu, Kangyu Song, Banghao Jian, Yuxuan Jiang, Wei Qiu, Quentin Liu, Zhengqi Lu, Wei Cai   +21 more
doaj   +1 more source

Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models

Neurobiology of Disease, 2023
The R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2) increases the risk of Alzheimer's disease (AD). To investigate potential mechanisms, we analyzed knockin mice expressing human TREM2-R47H from one mutant mouse Trem2 allele ...
Melanie Das, Wenjie Mao, Yuliya Voskobiynyk, Deanna Necula, Irene Lew, Cathrine Petersen, Allie Zahn, Gui-Qiu Yu, Xinxing Yu, Nicholas Smith, Faten A. Sayed, Li Gan, Jeanne T. Paz, Lennart Mucke   +13 more
doaj   +1 more source

An uncommon disease included commonly in the differential diagnosis of neurological diseases: Neuro-Behcet's syndrome

, 2021
Behcet's Syndrome (BS) may present with different neurological problems, related either directly (primary) or indirectly (secondary) to BS. Primary neurological involvement is named as neuro-Behcet's syndrome (NBS), and its two major subtypes that are ...
Uygunoglu, Ugur, Siva, Aksel
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

NIHSS Scores in Ischemic Small Vessel Disease: A Study in CADASIL [PDF]

, 2012
Background: The National Institutes of Health Stroke Scale (NIHSS) is widely used to measure neurological deficits, evaluate the effectiveness of treatment and predict outcome in acute ischemic stroke.
Herve, Dominique, Jouvent, Eric, Duering, Marco, Chabriat, Hugues, Allili, Nassira, Yao, Ming, Dichgans, Martin   +6 more
core   +1 more source