Results 41 to 50 of about 5,966,929 (265)

肌萎缩侧索硬化医疗质量控制指标 Medical Quality Control Indicators for Amyotrophic Lateral Sclerosis

Zhongguo cuzhong zazhi
国家神经系统疾病医疗质量控制中心于2022年设立了运动神经元病（motor neuron disease，MND）质控专病组，启动了肌萎缩侧索硬化（amyotrophic lateral sclerosis，ALS）/MND医疗质量控制体系建设。通过系统调研循证医学证据和国内外指南，MND质控专病组利用德尔菲法制定了ALS医疗质量控制指标体系，从统一诊断标准，建立患者全面管理概念，规范治疗方案等方面系统完善ALS的住院诊疗质量控制过程。该ALS医疗质量控制指标体系共15个指标 ...
The Motor Neuron Disease Working Group of National Center for Healthcare Quality Management in Neurological Diseases
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Clinically probable RBD is an early predictor of malignant non-motor Parkinson’s disease phenotypes

npj Parkinson's Disease
Non-motor symptoms (NMS) in Parkinson’s disease (PD) significantly impact quality of life, especially in later stages. REM sleep behavior disorder (RBD) affects approximately 42% of all PD patients and frequently precedes motor PD symptoms. RBD is linked
Alfonso Enrique Martinez-Nunez, Hunter Hutchinson, Patricia Coutinho, Filipe Pereira Sarmento, Venkat Srikar Lavu, Qingqi Yuan, Jagan Mohan Reddy Dwarampudi, Aysegul Gunduz, Gregory M. Pontone, Michael S. Okun, Joshua K. Wong   +10 more
doaj   +1 more source

TNFα increases tyrosine hydroxylase expression in human monocytes

npj Parkinson's Disease, 2021
Most, if not all, peripheral immune cells in humans and animals express tyrosine hydroxylase (TH), the rate limiting enzyme in catecholamine synthesis. Since TH is typically studied in the context of brain catecholamine signaling, little is known about ...
Adithya Gopinath, Martin Badov, Madison Francis, Gerry Shaw, Anthony Collins, Douglas R. Miller, Carissa A. Hansen, Phillip Mackie, Malú Gámez Tansey, Abeer Dagra, Irina Madorsky, Adolfo Ramirez-Zamora, Michael S. Okun, Wolfgang J. Streit, Habibeh Khoshbouei   +14 more
doaj   +1 more source

Temporal and Spatial Dynamics of Inflammasome Activation After Ischemic Stroke

Frontiers in Neurology, 2021
Background: The inflammasome represents a highly pro-inflammatory mechanism. It has been identified that inflammasome was activated after ischemic stroke. However, the impact of inflammasomes on stroke outcomes remains contradictory.
Danli Lu, Mengyan Hu, Bingjun Zhang, Yinyao Lin, Qiang Zhu, Xuejiao Men, Zhengqi Lu, Wei Cai, Wei Cai   +8 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Burden of neurological disorders in China and its provinces, 1990–2021: Findings from the global burden of disease study 2021 [PDF]

Background: The burden of neurological disorders in China has not been systematically analyzed. We aim to provide a comprehensive estimation of the national and subnational neurological burden across China from the Global Burden of Disease Study (GBD ...
Ma, Q, Yang, Xuan, Neurological Disorders Collabo, GBD 2021 China, Hao, J, Kisa, Adnan, Yin, P, Zhang, Chen, Kisa, Sezer, Yang, X, Ma, Qingfeng, Guo, Cui, Yin, Peng, GBD 2021 China Neurological Disorders Collaborators, Wan, D, Zhang, C, Zhou, Maigeng, Hao, Junwei, Wan, Dongshan, Zhou, M   +18 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Vestibular disease in dogs: association between neurological examination, MRI lesion localisation and outcome. [PDF]

, 2020
OBJECTIVES To determine whether the neurological examination correctly distinguishes between central and peripheral vestibular lesions in dogs. MATERIALS AND METHODS Retrospective study on dogs with vestibular disease presenting to two referral ...
J. Nessler, Stein, V M, A. Maiolini, Tipold, A, V. M. Stein, Bathen-Nöthen, A, A. Bathen‐Nöthen, Maiolini, A, Nessler, J, Bongartz, U, U. Bongartz, A. Tipold   +11 more
core   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source