Results 121 to 130 of about 69,989 (234)

A neonatal gnotobiotic pig model of human enterovirus 71 infection and associated immune responses

Emerging Microbes & Infections, 2014
Vaccine development and pathogenesis studies for human enterovirus 71 are limited by a lack of suitable animal models. Here, we report the development of a novel neonatal gnotobiotic pig model using the non-pig-adapted neurovirulent human enterovirus 71 strain BJ110, which has a C4 genotype.
Yang, Xingdong, Li, Guohua, Wen, Ke, Bui, Tammy, Liu, Fangning, Kocher, Jacob, Jortner, Bernard S., Vonck, Marlice, Pelzer, Kevin D., Deng, Jie, Zhu, Runan, Li, Yuyun, Qian, Yuan, Yuan, Lijuan   +13 more
openaire   +3 more sources

Molecular epidemiology and clinical features of hand, foot and mouth disease in northern Thailand in 2016: a prospective cohort study

BMC Infectious Diseases, 2018
Background Hand, foot and mouth disease (HFMD) is a major communicable disease in children ≤6 years old, particularly in several countries in the Asia-Pacific Region, including Thailand.
Panupong Upala, Tawatchai Apidechkul, Wipob Suttana, Niwed Kullawong, Ratipark Tamornpark, Chadaporn Inta   +5 more
doaj   +1 more source

Comparative analysis of viral shedding in pediatric and adult subjects with central nervous system-associated enterovirus infections from 2013 to 2015 in Switzerland. [PDF]

, 2017
Several enterovirus (EV) genotypes can result in aseptic meningitis, but their routes of access to the central nervous system remain to be elucidated and may differ between the pediatric and adult populations.
Ambrosioni, J., Asner, S., Cordey, S., Gonçalves, A.R., Kaiser, L., L'Huillier, A.G., Posfay-Barbe, K.M., Schibler, M., Turin, L., Wagner, N.   +9 more
core   +1 more source

Systematic Proteomic Characterization of EV‐A71‐Infected Mice Identifies Dynamic Molecular Changes and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
Time‐resolved multi‐omics of EV‐A71‐infected BALB/c mice uncovered dynamic host responses, revealing rapid neutrophil extracellular traps (NETs) activation as a key event. Screened drugs (kinase inhibitors) suppressed viral replication in vitro and in vivo, suggesting the promise of targeting host phosphorylation networks as a viable antiviral strategy.
Wanjun Peng, Qiaochu Wang, Binbin Zhao, Lihong Zhang, Jing Wu, Xiaohui Wei, Na Rong, Zhaohua Wang, Kaihui Liu, Jiangfeng Liu, Juntao Yang, Jiangning Liu   +11 more
wiley   +1 more source

Complete Genome Sequence of a Human Enterovirus 71 Strain Isolated in Brunei in 2006

Genome Announcements, 2013
ABSTRACT The complete genome sequence of a human enterovirus 71 strain isolated in Brunei in 2006 was determined. Phylogenetic analysis based on the complete genome sequence classified this strain into subgenogroup B5.
Zaini, Zainun, McMinn, Peter
openaire   +2 more sources

The Autophagic Machinery in Enterovirus Infection

Viruses, 2016
The Enterovirus genus of the Picornaviridae family comprises many important human pathogens, including polioviruses, rhinovirus, enterovirus A71, and enterovirus D68.
Jeffrey K. F. Lai, I-Ching Sam, Yoke Fun Chan   +2 more
doaj   +1 more source

Epidemiological and Clinical Characteristics of the Enterovirus D68 Outbreak in Spain in 2024 [PDF]

J Med Virol
ABSTRACT Enterovirus D68 (EV‐D68) is a significant cause of respiratory and neurological disease worldwide. In 2024, Spain experienced its largest recorded EV‐D68 outbreak, accounting for 37.4% of all typed EV (294/892). This study describes the epidemiological, clinical, and phylogenetic features of EV‐D68 infections.
Camacho J, García‐Ibáñez N, Fernández‐García M, Biya Y, Ruiz de Pedro E, Gutiérrez A, Nieto M, Ruiz‐García M, Pastor‐Fajardo M, Lagarejos E, de Leonardo Simón C, Navascués A, Moreno‐Docón A, Gozalo‐Marguello M, Berengua C, Antequera P, Huéscar‐Pascual M, Calvo C, Cabrerizo M.   +18 more
europepmc   +2 more sources

Impact of the BioFire FilmArray Meningitis‐Encephalitis Panel on Management of Suspected Paediatric Central Nervous System Infections: A Single‐Centre Retrospective Cohort Study

Journal of Paediatrics and Child Health, Volume 62, Issue 4, Page 586-593, April 2026.
ABSTRACT Background Meningoencephalitis causes significant morbidity and mortality in children worldwide. Prompt diagnosis remains challenging, yet advances in molecular diagnostic technology have improved diagnostic performance. This study examined whether the introduction of the BioFire FilmArray meningitis/encephalitis (ME) multiplex panel impacted ...
Louisa Mary Churcher, Adam William Bartlett, Stella Pendle, Rob Slade, Phoebe C. M. Williams   +4 more
wiley   +1 more source

Genome Characterisation of Enteroviruses 117 and 118: A New Group within Human Enterovirus Species C

PLoS ONE, 2013
The more than 120 genotypes of human enteroviruses (HEVs) reflect a wide range of evolutionary divergence, and there are 23 currently classified as human enterovirus C species (HEV-C). Two new HEV-C (EV-C117 and EV-C118) were identified in the Community-Acquired Pneumonia Pediatric Research Initiative (CAP-PRI) study, and the present paper describes ...
A. Piralla, C. Daleno, A. Scala, D. Greenberg, V. Usonis, N. Principi, F. Baldanti, S. Esposito, CAP PRI Study Group   +8 more
openaire   +6 more sources

A human intestinal organoid derived from fetal human colon cells model for studying enteroviral pathogenesis

Virulence
Human enteroviruses, including enterovirus 71 (EV71), cause hand, foot, and mouth disease (HFMD) and may lead to severe neurological diseases in infants.
Chengcheng Li, Yanxi Chen, Xing Zhou, Jiuxiu Lin, Zhen Luo   +4 more
doaj   +1 more source