Results 71 to 80 of about 69,989 (234)
Modeling viral infectious diseases and development of antiviral therapies using human induced pluripotent stem cell-derived systems [PDF]
, 2015 The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate ...
Barzon, Luisa +6 more
core +2 more sources
Advanced Science, EarlyView.This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun +19 more
wiley +1 more source
Antiviral Effect of Matrine against Human Enterovirus 71
Molecules, 2012 Human enterovirus 71, a member of the <em>Picornaviridae</em> family, is one of the major causative agent of hand, foot and mouth disease in children less than six years old. This illness has caused mortalities in large-scale outbreaks in the
Jiangning Liu +6 more
doaj +1 more source
Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1 [PDF]
, 2019 Comprehensive knowledge of the host factors required for picornavirus infection would facilitate antiviral development.
Adamovich +60 more
core +2 more sources
MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity
Advanced Science, EarlyView.During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen +12 more
wiley +1 more source
Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda. [PDF]
, 2019 Febrile illness is a major burden in African children, and non-malarial causes of fever are uncertain. In this retrospective exploratory study, we used metagenomic next-generation sequencing (mNGS) to evaluate serum, nasopharyngeal, and stool specimens ...
Byaruhanga, Oswald +17 more
core +3 more sources
Advanced Science, EarlyView.A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park +11 more
wiley +1 more source
Development of a enterovirus diagnostic assay system for diagnosis of viral myocarditis in humans [PDF]
Microbiology and Immunology, 2013 AbstractThe coxsackieviruses type B3 (CVB3) are members of the genus Enterovirus of the family Picornaviridae. They are the commonest cause of chronic myocarditis and dilated cardiomyopathy. However, there is still no effective method for diagnosing CVB3 infection in humans.
Byung-Kwan, Lim +6 more
openaire +2 more sources
Enteroviruses: A Gut-Wrenching Game of Entry, Detection, and Evasion
Viruses, 2019 Enteroviruses are a major source of human disease, particularly in neonates and young children where infections can range from acute, self-limited febrile illness to meningitis, endocarditis, hepatitis, and acute flaccid myelitis.
Alexandra I. Wells, Carolyn B. Coyne
doaj +1 more source
Human picornaviruses associated with neurological diseases and their neutralization by antibodies [PDF]
, 2017 Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system.
Ang +22 more
core +1 more source