Results 61 to 70 of about 27,128 (236)

Monitoring the VDPV2 outbreak in Egypt during 2020–2021 highlights the crucial role of environmental surveillance and boosting immunization in combating Poliovirus

BMC Infectious Diseases
Background Poliovirus is a highly infectious enterovirus (EV) that primarily affects children and can lead to lifelong paralysis or even death. Vaccine-derived polioviruses (VDPVs) are a great threat since they are derived from the attenuated virus in ...
Menna R. Shabana, Amira Y. Zaghloul, Tamer H. El Shaarawy, Nooran S. Elleboudy, Khaled M. Aboshanab   +4 more
doaj   +1 more source

Enterovirus Replication Organelles and Inhibitors of Their Formation

Frontiers in Microbiology, 2020
Enteroviral replication reorganizes the cellular membrane. Upon infection, viral proteins and hijacked host factors generate unique structures called replication organelles (ROs) to replicate their viral genomes.
Xinhong Li, Xinhong Li, Xinhong Li, Mingshu Wang, Mingshu Wang, Mingshu Wang, Anchun Cheng, Anchun Cheng, Anchun Cheng, Xingjian Wen, Xingjian Wen, Xingjian Wen, Xumin Ou, Xumin Ou, Xumin Ou, Sai Mao, Sai Mao, Sai Mao, Qun Gao, Qun Gao, Qun Gao, Di Sun, Di Sun, Di Sun, Renyong Jia, Renyong Jia, Renyong Jia, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Dekang Zhu, Dekang Zhu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Bin Tian, Bin Tian, Leichang Pan, Leichang Pan, Xiaoyue Chen, Xiaoyue Chen, Xiaoyue Chen   +62 more
doaj   +1 more source

Aseptic Meningitis Epidemic during a West Nile Virus Avian Epizootic

Emerging Infectious Diseases, 2003
While enteroviruses have been the most commonly identified cause of aseptic meningitis in the United States, the role of the emerging, neurotropic West Nile virus (WNV) is not clear.
Kathleen G. Julian, James A. Mullins, Annette Olin, Heather Peters, W. Allan Nix, M. Steven Oberste, Judith C. Lovchik, Amy Bergmann, Ross J. Brechner, Robert A. Myers, Anthony A. Marfin, Grant L. Campbell   +11 more
doaj   +1 more source

Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses.

European journal of medicinal chemistry, 2019
The hydrophobic pocket within viral capsid protein 1 is a target to combat the rhino- and enteroviruses (RV and EV) using small molecules. The highly conserved amino acids lining this pocket enable the development of antivirals with broad-spectrum of ...
A. Egorova, S. Ekins, M. Schmidtke, V. Makarov   +3 more
semanticscholar   +1 more source

A preterm neonate with infantile liver failure syndrome 1 due to leucyl‐tRNA synthetase 1 gene (LARS1) mutations with a histopathologic phenotype of neonatal hemochromatosis

JPGN Reports, EarlyView.
Abstract We report a case of a premature, growth‐restricted female infant with feeding intolerance and coagulopathy, treated initially for sepsis, who progressed to neonatal acute liver failure and end‐stage hepatic encephalopathy after a prolonged hospitalization with extensive diagnostic evaluation, and was found by autopsy to have histopathologic ...
Adrienne Bruder, Naomi Laventhal, Raja Rabah, Jacqueline Meadow   +3 more
wiley   +1 more source

Biochemical testing and pathology reveal rare cause of pediatric acute liver failure: Hyperornithinemia‐hyperammonemia‐homocitrullinuria syndrome

JPGN Reports, EarlyView.
Abstract Hyperornithinemia‐hyperammonemia‐homocitrullinuria (HHH) syndrome is a rare metabolic condition that can cause lethargy, ataxia, tachypnea, nausea, vomiting, seizures, coma, and acute liver failure. We present a 26‐month‐old female with acute liver failure who was diagnosed with HHH 1 week after admission. Histology revealed an acute hepatitic
Tierra L. Mosher, Kathryn S. Czepiel, Matthew B. Neu, Andrea Carolina Cortes Fernandez, L. Walden Browne, Annie D. Niehaus, Roberto Gugig   +6 more
wiley   +1 more source

Enteroviruses in the etiology of acute respiratory viral infections in children, Novosibirsk, Russia

Юг России: экология, развитие
Aim. To assess the contribution of human enteroviruses to the overall structure of acute respiratory viral infections in children in Novosibirsk during the epidemic season 2022–2023.   Material and Methods.
O. G. Kurskaya, T. A. Saroyan, A. R. Nokhova, N. A. Dubovitskiy, A. A. Derko, P. S. Basova, T. A. Gutova, M. V. Solomatina, T. A. Murashkina, K. A. Sharshov   +9 more
doaj   +1 more source

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

PLoS Biology, 2019
Rhino- and enteroviruses are important human pathogens, against which no antivirals are available. The best-studied inhibitors are “capsid binders” that fit in a hydrophobic pocket of the viral capsid.
R. Abdelnabi, James A. Geraets, Yipeng Ma, C. Mirabelli, J. Flatt, Aušra Domanska, L. Delang, D. Jochmans, T. A. Kumar, Venkatesan Jayaprakash, B. N. Sinha, P. Leyssen, S. Butcher, J. Neyts   +13 more
semanticscholar   +1 more source

Nail Disorders in Systemic Conditions

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail findings in children can be indicative of an underlying systemic disease. Many of these findings are seen in multiple entities and are not specific to one disease. The importance of specifically examining for these nail changes cannot be overstated.
Jane Sanders Bellet
wiley   +1 more source

Detection of Nonpolio Enteroviruses among children with acute flaccid paralysis from institutions and from migrants’ families

Журнал инфектологии, 2014
Aim: to study of the frequency of isolation and determination of the spectrum of enterovirus serotypes excreted by children living in the North-Western region of Russia and children arriving in this region from unsafe territories.Materials and methods ...
N. I. Romanenkova, O. I. Kanaeva, M. A. Bichurina, N. R. Rozaeva   +3 more
doaj   +1 more source