Results 61 to 70 of about 5,862 (206)
T cells, the Next Big Target in Axial Spondyloarthritis?
Arthritis &Rheumatology, EarlyView.Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley +1 more source
Advancing tendon-to-bone enthesis repair:from biomimetic materials to microRNA modulation [PDF]
The insertion between tendons and bones is called enthesis. Injuries at the enthesis account for a significant proportion of all sport-related injuries. Additionally, sedentarism, obesity, and ageing are risk factors for enthesis injuries.
Peniche Silva, Carlos Julio
core +1 more source
, 2020 The enthesis is a specialised tissue interface between tendon and bone, essential for adequate force transmission. Following injuries and surgical repair, the enthesis is often not re-established and traditionally used tissue substitutes have lacked to ...
Pugliese, Eugenia +1 more
core +2 more sources
Arthritis &Rheumatology, EarlyView.Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede +11 more
wiley +1 more source
Histological scale used to assess the tissue engineering of the enthesis.
, 2013 The first 3 columns are visual grades assigned by examining x 25 images of the bone-tendon junction. The last 2 columns are assessments of x 100 images.
Colette Salvat (362460) +8 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective The gut–joint axis is a central paradigm in spondyloarthritis, yet the cellular mechanisms linking intestinal and joint immunity remain poorly understood. One potential link is T cell receptor αβ+ CD4+ colon intraepithelial lymphocytes (cIELs) that can traffic to extraintestinal tissues, including the joint.
Sarah M. Danielson +4 more
wiley +1 more source
Tendon-to-bone enthesis as a structured nanomaterial [PDF]
, 2014 Tendon attaches to bone through a hierarchical and spatial graded structure called the enthesis. Entheses at the rotator cuff of the humeral head are highly resilient against injury in younger adults, but tears are common in older adults.
Boyle, John +8 more
core
Multimaterial and multiscale scaffold for engineering enthesis organ
, 2023 Tendon and ligament injuries are relevant clinical problems in modern society, and the current medical approaches do not guarantee complete recovery of the physiological functionalities. Moreover, they present a non-negligible failure rate after surgery.
Russo, Lara +17 more
core +1 more source
EFFECT OF STRETCHING STIMULATION DURING CULTURE ON MENISCAL ENTHESIS CONSTRUCTS [PDF]
, 2021 96 pagesTissue engineered (TE) menisci have been seen as a very promising treatment for meniscus injury repair in human knee joints. Although much effort has been focused on the TE meniscus body, less attention has been paid to the connective integration
Wang, Xun
core +1 more source
Arthritis &Rheumatology, Accepted Article.Objective The Diagnostic Ultrasound Enthesitis Tool (DUET) study aimed to develop and validate a new sonographic scoring system for enthesitis to aid PsA diagnosis. Methods We prospectively enrolled patients with early PsA, psoriasis without arthritis (PsO), and non‐inflammatory musculoskeletal symptoms as controls (CTL) from 17 centers. A standardized
Lihi Eder +27 more
wiley +1 more source