Results 41 to 50 of about 5,862 (206)

TGF-β1 derived from macrophages contributes to load-induced tendon-bone healing in the murine rotator cuff repair model by promoting chondrogenesis

open access: yesBone & Joint Research, 2023
Aims: It has been established that mechanical stimulation benefits tendon-bone (T-B) healing, and macrophage phenotype can be regulated by mechanical cues; moreover, the interaction between macrophages and mesenchymal stem cells (MSCs) plays a ...
Linfeng Wang   +7 more
doaj   +1 more source

Local anisotropy in mineralized fibrocartilage and subchondral bone beneath the tendon-bone interface

open access: yesScientific Reports, 2021
The enthesis allows the insertion of tendon into bone thanks to several remarkable strategies. This complex and clinically relevant location often features a thin layer of fibrocartilage sandwiched between tendon and bone to cope with a highly ...
Alexandra Tits   +8 more
doaj   +1 more source

Consilient evidence affirms expansive stabilizing ligaments in the tyrannosaurid foot

open access: yesVertebrate Anatomy, Morphology, Palaeontology, 2022
Tyrannosaurid dinosaurs were ecologically unique vertebrates as the sole clade of large terrestrial carnivores (adults >400 kg) in their continent-spanning habitats.
Lara Surring   +7 more
doaj   +1 more source

Enthesis: A Brief Review

open access: yesApollo Medicine, 2015
Abstract Bone is a living tissue capable of changing its structure as the result of the stress to which it is subjected. It consists of cells, fibers and matrix. Calcification of extra cellular matrix makes it hard. The slight degree of elasticity in the bone is due to the presence of the organic fibers. The main function of the bone is protection of
Nitya Waghray   +4 more
openaire   +1 more source

Negative impact of disuse and unloading on tendon enthesis structure and function

open access: yes, 2021
International audienceExposure to chronic skeletal muscle disuse and unloading that astronauts experience results in muscle deconditioning and bone remodeling.
Camy, Claire   +11 more
core   +1 more source

Innate Lymphoid Cells are Present at Healthy Patients Spinal Enthesis, Providing a Potential Mechanism for Spondyloarthropathy Pathogenesis

open access: yesGlobal Spine Journal, 2016
Background The pathogenesis of murine spondyloarthropathy (SpA) has been intimately linked to the presence of Interleukin(IL)-23 responsive, innate like lymphocytes at different anatomical regions including spinal enthesis. Human SpAs are associated with
Richard Cuthbert   +5 more
doaj   +1 more source

Growth and mechanobiology of the tendon-bone enthesis

open access: yesSeminars in Cell & Developmental Biology, 2022
Tendons are cable-like connective tissues that transfer both active and passive forces generated by skeletal muscle to bone. In the mature skeleton, the tendon-bone enthesis is an interfacial zone of transitional tissue located between two mechanically dissimilar tissues: compliant, fibrous tendon to rigid, dense mineralized bone.
openaire   +2 more sources

Why Inhibition of IL-23 Lacked Efficacy in Ankylosing Spondylitis

open access: yesFrontiers in Immunology, 2021
The term spondyloarthritis pertains to both axial and peripheral arthritis including ankylosing spondylitis (AS) and psoriatic arthritis (PsA), which is strongly linked to psoriasis and also the arthritis associated with inflammatory bowel disease.
Dennis McGonagle   +8 more
doaj   +1 more source

The Effects of Downhill Running and Maturation on Histological and Morphological Properties of Tendon and Enthesis in Mice

open access: yesBiology, 2023
To date, it remains unclear how overuse affects the tendons and entheses at different stages of maturation. Therefore, we evaluated histological and morphological changes in the tendons and entheses in adolescent (4-week-old) and adult mice (8-week-old ...
Kaichi Ozone   +4 more
doaj   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

open access: yesAdvanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan   +8 more
wiley   +1 more source

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