Results 41 to 50 of about 3,843 (182)

New perspectives in enthesis ultrasound: validation of enthesis fibrocartilage

International Journal of Clinical Rheumatology, 2011
Evaluation of: Aydin SZ, Bas E, Basci O et al.: Validation of ultrasound imaging for Achilles entheseal fibrocartilage in bovines and description of changes in humans with spondyloarthritis. Ann. Rheum. Dis. 69(12), 2165–2168 (2010). Enthesitis, the hallmark of spondyloarthritis is underestimated in clinical practice and improving the knowledge of ...
openaire   +1 more source

Hedgehog signaling directs cell differentiation and plays a critical role in tendon enthesis healing

npj Regenerative Medicine
A high prevalence of rotator cuff tears presents a major clinical challenge. A better understanding of the molecular mechanisms underlying enthesis development and healing is needed for developing treatments.
Fei Fang, Matthew Casserly, Julia Robbins, Stavros Thomopoulos   +3 more
doaj   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Millimeter‐Scale Dual‐Opposing RNA‐Gradient Hydrogel for Interfacial Gene Silencing

Advanced Science, EarlyView.
A branched microfluidic platform enables the fabrication of millimeter‐scale hydrogels with dual‐opposing RNA‐gradients for precise spatial control of cell gene expression. This device allows for the generation of multiple constructs at once, offering potential for future engineering of complex tissue interfaces with improved physiological relevance ...
Tyler Hoffman, Cong Truc Huynh, Marcus J. Goudie, Peyton J. Tebon, Hyojin Ko, Minh Khanh Nguyen, Kaelyn L. Gasvoda, Yang Song, Kirsten Fetah, Ali Khademhosseini, Song Li, Eben Alsberg   +11 more
wiley   +1 more source

Mineral Distributions at the Developing Tendon Enthesis

PLoS ONE, 2012
Tendon attaches to bone across a functionally graded interface, "the enthesis". A gradient of mineral content is believed to play an important role for dissipation of stress concentrations at mature fibrocartilaginous interfaces. Surgical repair of injured tendon to bone often fails, suggesting that the enthesis does not regenerate in a healing setting.
Andrea G Schwartz, Jill D Pasteris, Guy M Genin, Tyrone L Daulton, Stavros Thomopoulos   +4 more
openaire   +4 more sources

Decoding the mechanical characteristics of the human anterior cruciate ligament entheses through graduated mineralization interfaces

Nature Communications
The anterior cruciate ligament is anchored to the femur and tibia via specialized interfaces known as entheses. These play a critical role in ligament homeostasis and joint stability by transferring forces, varying in magnitude and direction between ...
Jinghua Fang, Xiaozhao Wang, Huinan Lai, Wenyue Li, Xudong Yao, Zongyou Pan, Renwei Mao, Yiyang Yan, Chang Xie, Junxin Lin, Wei Sun, Rui Li, Jiajie Wang, Jiacheng Dai, Kaiwang Xu, Xinning Yu, Tengjing Xu, Wangping Duan, Jin Qian, Hongwei Ouyang, Xuesong Dai   +20 more
doaj   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

Enthesis regeneration: a role for Gli1+ progenitor cells [PDF]

Development, 2017
The tendon enthesis originates from a specific pool of hedgehog-active Gli1+ progenitor cells that differentiate and produce mineralized fibrocartilage. The current study investigated the regenerative capacity of this cell population by comparing the responses of early postnatal and mature entheses to injury.
Andrea G. Schwartz, Leesa M. Galatz, Stavros Thomopoulos   +2 more
openaire   +2 more sources

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Multimaterial Triphasic Scaffold Replicates Enthesis Microenvironment to Modulate Early Cell Responses

Advanced NanoBiomed Research, EarlyView.
A bioinspired triphasic scaffold integrating 3D printed polycaprolactone and electrospun poly(lactic‐co‐glycolic acid) is developed to replicate the organization of the tendon‐to‐bone enthesis. Cyclic mechanical stimulation induces spatially defined cell morphology and lineage‐related gene expression in human mesenchymal stem cells, highlighting the ...
Ginevra Pegollo, Simone Micalizzi, Girish Pattappa, Philipp Stahlhut, Jürgen Groll, Carmelo De Maria, Denitsa Docheva, Giovanni Vozzi   +7 more
wiley   +1 more source