Results 31 to 40 of about 5,862 (206)

Mechanical stimulation promotes enthesis injury repair by mobilizing Prrx1+ cells via ciliary TGF-β signaling

eLife, 2022
Proper mechanical stimulation can improve rotator cuff enthesis injury repair. However, the underlying mechanism of mechanical stimulation promoting injury repair is still unknown. In this study, we found that Prrx1+ cell was essential for murine rotator
Han Xiao, Tao Zhang, Changjun Li, Yong Cao, Linfeng Wang, Huabin Chen, Shengcan Li, Changbiao Guan, Jianzhong Hu, Di Chen, Can Chen, Hongbin Lu   +11 more
doaj   +1 more source

Pathogenesis of the Hallux Valgus: Enthesopathy of the Metatarsosesamoid Ligament

Foot & Ankle Orthopaedics, 2023
Category: Bunion; Basic Sciences/Biologics Introduction/Purpose: It is generally accepted that failure of the medial supporting soft tissue structure of the metatarsophalangeal joint plays an important role in the development of hallux valgus.
Hiroki Yabiku MD, Kotaro Higa MD
doaj   +1 more source

SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis Insights

Frontiers in Immunology, 2021
ObjectiveBacterial and viral infectious triggers are linked to spondyloarthritis (SpA) including psoriatic arthritis (PsA) development, likely via dendritic cell activation.
Qiao Zhou, Qiao Zhou, Qiao Zhou, Jayakumar Vadakekolathu, Abdulla Watad, Kassem Sharif, Tobias Russell, Hannah Rowe, Almas Khan, Peter A. Millner, Peter Loughenbury, Abhay Rao, Robert Dunsmuir, Jake Timothy, Giovanni Damiani, Giovanni Damiani, Paolo D. M. Pigatto, Paolo D. M. Pigatto, Piergiorgio Malagoli, Giuseppe Banfi, Yasser M. El-Sherbiny, Charlie Bridgewood, Dennis McGonagle, Dennis McGonagle   +23 more
doaj   +1 more source

Genetic lineage tracing of targeted cell populations during enthesis healing. [PDF]

, 2018
Rotator cuff supraspinatus tendon injuries are clinically challenging due to the high rates of failure after surgical repair. One key limitation to functional healing is the failure to regenerate the enthesis transition between tendon and bone, which ...
Galatz, Leesa M, Huang, Alice H, Zumstein, Matthias, Laudier, Damien, Moser, Helen L., Meier, Kristen, Doe, Anton P., Moser, Helen Laura, Galatz, Leesa M., Doe, Anton P, Akiyama, Haruhiko, Garnier, Simon, Huang, Alice H., Zumstein, Matthias A., Doe AP, Laudier D, Galatz LM, Moser HL, Huang AH, Garnier S, Akiyama H, Zumstein MA, Meier K   +22 more
core   +2 more sources

Anatomy and histomorphology of the flexor digitorum profundus enthesis: functional implications for tissue engineering and surgery

BMC Musculoskeletal Disorders, 2021
Background The enthesis possesses morphological adaptations across the soft-hard tissue junction which are not fully restored during surgical avulsion repairs.
Jeremy W. Mortimer, Hamad Alsaykhan, Subashan Vadibeler, Philippa A. Rust, Jennifer Z. Paxton   +4 more
doaj   +1 more source

Growth and mechanobiology of the Achilles enthesis in mice

, 2021
Killian, Megan L.Santare, Michael H.Entheses are connective tissues that connect tendon to bone, two vastly different hierarchical materials with different structural and mechanical properties. As a result of this material mismatch, entheses are prone to
Ganji, Elahe
core   +1 more source

Primary cilia as the nexus of biophysical and hedgehog signaling at the tendon enthesis [PDF]

, 2020
The tendon enthesis is a fibrocartilaginous tissue critical for transfer of muscle forces to bone. Enthesis pathologies are common, and surgical repair of tendon to bone is plagued by high failure rates.
Moore, Emily R, Sup, McKenzie E, Schwartz, Andrea G, Fang, Fei, Thomopoulos, Stavros   +4 more
core   +1 more source

Enthesis Repair [PDF]

Journal of Bone and Joint Surgery, 2018
Abstract: On May 22, 2017, the National Institutes of Health (NIH)/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) hosted a roundtable on “Innovative Treatments for Enthesis Repair.” A summary of the roundtable discussion, as well as a list of the extramural participants, can be found at https://www.niams.nih.gov/
Kathleen A. Derwin, Leesa M. Galatz, Anthony Ratcliffe, Stavros Thomopoulos   +3 more
openaire   +2 more sources

Optical anisotropy reveals molecular order in a mouse enthesis

, 2016
FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOEntheses are specialized biological structures that functionally anchor tendons to bones. The complexity, mechanical characteristics and properties of the entheses, particularly those related ...
Vidal, Benedicto de Campos, Dos Anjos, Eli Heber M, Mello, Maria Luiza S.   +2 more
core   +2 more sources

The enthesis: a review of the tendon-to-bone insertion [PDF]

, 2014
The integration of tendon into bone occurs at a specialized interface known as the enthesis. The fibrous tendon to bone enthesis is established through a structurally continuous gradient from uncalcified tendon to calcified bone.
Dwyer, Corey R., Russell, Ryan P., Weinreb, Jeffrey H., Cote, Mark P., Beitzel, Knut, Apostolakos, John, Alaee, Farhang, McCarthy, Mary Beth R., Durant, Thomas J. S., Mazzocca, Augustus D., John Apostolakos   +10 more
core   +2 more sources