Results 11 to 20 of about 39,445 (247)

Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands

Nature Communications, 2022
Extensive studies concluded that homophilic interactions between pre- and postsynaptic teneurins, evolutionarily conserved cell-adhesion molecules, encode the specificity of synaptic connections.
Xuchen Zhang, Pei-Yi Lin, Kif Liakath-Ali, Thomas C. Südhof   +3 more
doaj   +1 more source

Correlation Analysis of the Entorhinal Cortex-Hippocampus Nerve Fiber Changes and Memory Dysfunction in P301L-Tau Mouse Model and Molecular Mechanism

康复学报, 2023
ObjectiveTo observe the correlation between the changes of entorhinal cortex-hippocampus nerve fibers and learning and memory function in the P301L-Tau mouse model of Alzheimer's disease (AD) and related molecular mechanism, so as to provide the evidence
CHEN Xiaocheng, LIANG Shengxiang, LIN Bingbing, LIU Weilin, HUANG Jia   +4 more
doaj  

Left entorhinal cortex and object recognition [PDF]

NeuroReport, 2018
The present research explored the role of the medial temporal lobes in object memory in the unique patient MR, who has a selective lesion to her left lateral entorhinal cortex. Two experiments explored recognition memory for object identity and object location in MR and matched controls.
James, Adele, von Oertzen, Tim J., Norbury, Ray, Huppertz, Hans-Juergen, Brandt, Karen R.   +4 more
openaire   +5 more sources

An Optimized Deep Learning Model for Predicting Mild Cognitive Impairment Using Structural MRI

Sensors, 2023
Early diagnosis of mild cognitive impairment (MCI) with magnetic resonance imaging (MRI) has been shown to positively affect patients’ lives. To save time and costs associated with clinical investigation, deep learning approaches have been used widely to
Esraa H. Alyoubi, Kawthar M. Moria, Jamaan S. Alghamdi, Haythum O. Tayeb   +3 more
doaj   +1 more source

What Does the Anatomical Organization of the Entorhinal Cortex Tell Us?

Neural Plasticity, 2008
The entorhinal cortex is commonly perceived as a major input and output structure of the hippocampal formation, entertaining the role of the nodal point of cortico-hippocampal circuits. Superficial layers receive convergent cortical information, which is
Cathrin B. Canto, Floris G. Wouterlood, Menno P. Witter   +2 more
doaj   +1 more source

Mapping sequence structure in the human lateral entorhinal cortex

eLife, 2019
Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a route through ...
Jacob LS Bellmund, Lorena Deuker, Christian F Doeller   +2 more
doaj   +1 more source

Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease

Neural Plasticity, 2010
All neurons are not created equal. Certain cell populations in specific brain regions are more susceptible to age-related changes that initiate regional and system-level dysfunction.
Alexis M. Stranahan, Mark P. Mattson
doaj   +1 more source

Intrinsic Projections of Layer Vb Neurons to Layers Va, III, and II in the Lateral and Medial Entorhinal Cortex of the Rat

Cell Reports, 2018
Summary: Layer V of the entorhinal cortex (EC) receives input from the hippocampus and originates main entorhinal outputs. The deep-sublayer Vb, immunopositive for the transcription factor Ctip2, is thought to be the main recipient of hippocampal ...
Shinya Ohara, Mariko Onodera, Øyvind W. Simonsen, Rintaro Yoshino, Hiroyuki Hioki, Toshio Iijima, Ken-Ichiro Tsutsui, Menno P. Witter   +7 more
doaj   +1 more source

Rat hippocampal CA1 region represents learning-related action and reward events with shorter latency than the lateral entorhinal cortex

Communications Biology, 2023
The hippocampus and entorhinal cortex are deeply involved in learning and memory. However, little is known how ongoing events are processed in the hippocampal-entorhinal circuit.
Shogo Soma, Shinya Ohara, Satoshi Nonomura, Naofumi Suematsu, Junichi Yoshida, Eva Pastalkova, Yutaka Sakai, Ken-Ichiro Tsutsui, Yoshikazu Isomura   +8 more
doaj   +1 more source

Entorhinal cortex dysfunction in Alzheimer's disease

Trends in Neurosciences, 2023
The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and cell death. Recently, brain imaging studies from preclinical AD patients and electrophysiological recordings from AD animal models have shown that impaired neuronal ...
openaire   +4 more sources