Results 81 to 90 of about 49,661 (296)

Coalescing neutron stars - a step towards physical models III. Improved numerics and different neutron star masses and spins [PDF]

, 2001
(Abridged) In this paper we present a compilation of results from our most advanced neutron star merger simulations, including a description of the employed numerical procedures and a more complete overview over a large number of computed models.
Akmal, Ayal, Baumgarte, Baumgarte, Baumgarte, Bildsten, Blanchet, Blandford, Bonazzola, Bulik, Centrella, Colella, Cook, Cook, Cook, Cooperstein, Cutler, Davies, Duncan, Eichler, Faber, Faber, Flanagan, Freiburghaus, Fryer, H.-Th. Janka, Haensel, Heiselberg, Hilf, Hulse, Janka, Janka, Kalogera, Kochanek, Lai, Lai, Lai, Lai, Lai, Lattimer, Lattimer, Lattimer, Lattimer, Lee, Li, Lombardi, M. Ruffert, Marronetti, Meyer, Mészáros, Mészáros, Nakamura, New, Oohara, Oohara, Paczynski, Paczynski, Popham, Qian, Rasio, Rasio, Rasio, Rosswog, Rosswog, Ruffert, Ruffert, Ruffert, Ruffert, Ruffert, Ruffert, Sawyer, Shen, Shibata, Shibata, Shibata, Shibata, Sumiyoshi, Swesty, Symbalisty, Taniguchi, Thorne, Thorne, Tscharnuter, van den Horn, Waxman, Waxman, Woosley, Woosley, Zhuge   +88 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Analysis of Entropy Generation Rate in an Unsteady Porous Channel Flow with Navier Slip and Convective Cooling

Entropy, 2013
This study deals with the combined effects of Navier Slip, Convective cooling, variable viscosity, and suction/injection on the entropy generation rate in an unsteady flow of an incompressible viscous fluid flowing through a channel with permeable walls.
Oluwole Daniel Makinde, Tirivanhu Chinyoka   +1 more
doaj   +1 more source

Hall Current and Joule Heating Effects on Flow of Couple Stress Fluid with Entropy Generation [PDF]

, 2018
In this work, an analytical study of the effects of Hall current and Joule heating on the entropy generation rate of couple stress fluid is performed. It is assumed that the applied pressure gradient induces fluid motion.
Agboola, O.O., Bishop, S.A., Okagbue, H. I., Opanuga, A. A.   +3 more
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Combined Effect of Buoyancy Force and Navier Slip on Entropy Generation in a Vertical Porous Channel

Entropy, 2012
In this paper, we investigate the combined effects of buoyancy force and Navier slip on the entropy generation rate in a vertical porous channel with wall suction/injection.
Oluwole Daniel Makinde, Adetayo Samuel Eegunjobi   +1 more
doaj   +1 more source

Flow and Temperature Fields in Cooling Devices with Embedded Serpentine Tubes [PDF]

, 2014
The turbulent flow (Re = 5124) and conjugate heat transfer in heat-sink designs of the tube-on-plate type are numerically investigated. The cooling configurations employ a serpentine tube partially (or fully) embedded inside the plate.
E. Papanicolaou, G. C. Bergeles, I. K. Karathanassis, Kim D. W., Kobayashi H., V. Belessiotis   +5 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source