Results 91 to 100 of about 255,733 (268)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Surface Nanostructuring of Copper Using Fluoride and Chloride
ChemElectroChemCopper is an active electrocatalyst for various energy conversion reactions, but its performance depends on the structure of the active surface sites. In this work, we propose a simple strategy to tailor both the roughness and the active site's geometry ...
Vicente Pascual‐Llorens +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Field emission effect in triboelectric nanogenerators
Nature CommunicationsTriboelectric nanogenerators (TENGs) have garnered increasing attention due to their exceptional ability to convert mechanical energy into electricity.
Di Liu +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Nano-Micro LettersHighlights Systematically expounding functional design of reported triboelectric nanogenerators (TENGs). Conducting an extensive comparison of the power conversion efficiencies of TENGs in air and water wave environments.
Ying Lou +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Explaining the entropy concept and entropy components [PDF]
, 2017 Total entropy of a thermodynamic system consists of two components: thermal entropy due to energy, and residual entropy due to molecular orientation. In this article, a three-step method for explaining entropy is suggested. Step one is to use a classical method to introduce thermal entropy S
openaire +3 more sources
Effect of Zr on precipitation kinetics of Fe-Cr-Al alloys
Heat Treatment and Surface EngineeringThe present work investigated the effect of Zr on the precipitation behavior and mechanical properties of Fe-13.5Cr-4.73Al-2.07Mo-(0.34∼0.45)Nb-(0.65∼0.87)Ta-(0.11∼0.33)Zr (wt. %) alloys.
Ben Niu +5 more
doaj +1 more source