Results 101 to 110 of about 1,137,287 (295)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Phase-shift engineered triboelectric nanogenerators for constant-voltage output and efficient energy harvesting

Communications Materials
Triboelectric nanogenerators (TENGs) have emerged as a promising technology for harvesting ambient mechanical energy, their practical deployment has been strongly underpinned by their excellent inherent capabilities for ambient mechanical energy ...
Xinyuan Li, Lijiang Yin, Pengbo Li, Jie Wang   +3 more
doaj   +1 more source

Rapidity dependence of entropy production in proton- and nucleus-induced reactions on heavy nuclei [PDF]

, 2006
The entropy of hot nuclear systems is deduced from the mass distribution of fragments emitted from high energy proton- and nucleus-induced reactions via a quantum statistical model. It is found that the entropy per baryon, S/A, of intermediate rapidity ("
Jacak, Barbara V., Stöcker, Horst, Westfall, Gary D.   +2 more
core  

Memory and Entropy

Entropy, 2022
I study the physical nature of traces. Surprisingly, (i) systems separation with (ii) temperature differences and (iii) long thermalization times are sufficient conditions to produce macroscopic traces. Traces of the past are ubiquitous because these conditions are largely satisfied in our universe.
openaire   +5 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Drift-free ferroelectric photodetection with fast temporal response via thermal diffusion engineering

Nature Communications
Self-powered ferroelectric photodetectors offer an attractive platform for low-power optoelectronics, exploiting intrinsic bulk photovoltaic effects to achieve bias-free operation.
Jabir Zamir Minhas, Weiqi Qian, Lan Xu, Chong Guo, Chris R. Bowen, Ya Yang   +5 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Kolmogorov-Sinai Entropy Rate versus Physical Entropy

Physical Review Letters, 1999
This paper elucidates the connection between the KS entropy-rate kappa and the time evolution of the physical or statistical entropy S. For a large family of chaotic conservative dynamical systems including the simplest ones, the evolution of S(t) for far-from-equilibrium processes includes a stage during which S is a simple linear function of time ...
LATORA, Vito Claudio, M. BARANGER
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source