Results 111 to 120 of about 312,386 (294)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Second Law Analysis of AlO-Water Nanofluid Turbulent Forced Convection in a Circular Cross Section Tube with Constant Wall Temperature

Advances in Mechanical Engineering, 2013
The present paper proposes an analysis based on the second principle of thermodynamics applied to a water-Al 2 O 3 nanofluid. The nanofluid flows inside a circular section tube subjected to constant wall temperature.
Vincenzo Bianco, Oronzio Manca, Sergio Nardini   +2 more
doaj   +1 more source

Entropy Generation Analysis of the Flow Boiling in Microgravity Field. [PDF]

Entropy (Basel), 2022
Sun Z, Zhang H, Wang Q, Sun W.
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Sensitivity Analysis of Entropy Generation in Nanofluid Flow inside a Channel by Response Surface Methodology

Entropy, 2016
Nanofluids can afford excellent thermal performance and have a major role in energy conservation aspect. In this paper, a sensitivity analysis has been performed by using response surface methodology to calculate the effects of nanoparticles on the ...
Bijan Darbari, Saman Rashidi, Javad Abolfazli Esfahani   +2 more
doaj   +1 more source

Entropy Generation Analysis in Turbulent Reacting Flows and Near Wall: A Review. [PDF]

Entropy (Basel), 2022
Sadiki A, Agrebi S, Ries F.
europepmc   +1 more source

Weak randomness in device independent quantum key distribution and the advantage of using high dimensional entanglement

, 2013
We show that in device independent quantum key distribution protocols the privacy of randomness is of crucial importance. For sublinear test sample sizes even the slightest guessing probability by an eavesdropper will completely compromise security.
Huber, Marcus, Pawlowski, Marcin
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Entropy generation analysis for MHD flow of water past an accelerated plate. [PDF]

Sci Rep, 2021
Abdelhameed TN.
europepmc   +1 more source