Results 71 to 80 of about 25,153,568 (292)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Global Sensitivity Analysis Based on Entropy: From Differential Entropy to Alternative Measures
, 2021 Differential entropy can be negative, while discrete entropy is always non-negative. This article shows that negative entropy is a significant flaw when entropy is used as a sensitivity measure in global sensitivity analysis.
Zdeněk Kala, Kala, Zdeněk
core +1 more source
A mathematical model for entropy generation in a Powell-Eyring nanofluid flow in a porous channel
Heliyon, 2019 The continuous generation of entropy leads to exergy destruction which reduces the performance of a physical system. Hence, entropy minimization becomes necessary.
Hammed Abiodun Ogunseye +1 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Is There a Unique Physical Entropy? Micro versus Macro [PDF]
, 2012 Entropy in thermodynamics is an extensive quantity, whereas standard methods in statistical mechanics give rise to a non-extensive expression for the entropy. This discrepancy is often seen as a sign that basic formulas of statistical mechanics should be
Dieks, D.G.B.J. +4 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Entropy Generation on MHD Slip Flow Over a Stretching Cylinder with Heat Generation/Absorption [PDF]
, 2018 In the present study, we have investigated entropy generation on a magnetohydrodynamic fluid flow and heat transfer over a stretching cylinder with a porous medium in slip flow regime. A uniform heat source and radiation is also considered.
S. Bohra, Jain, S., Bohra, S., S. Jain
core +1 more source
Energy Science & Engineering, 2023 Complex implicit expressions and many intermediate parameters are not conducive to the application of entropy generation optimization to the performance of thermal and energy systems from component and system perspectives.
Chenzhi Ju +5 more
doaj +1 more source
Analysis of Entropy Generation in a Rectangular Porous Duct
Journal of Applied Mathematics and Physics, 2016 In this paper, we have considered a fully developed flow of a viscous incompressible fluid in a rectangular porous duct saturated with the same fluid. The duct is heated from the bottom for forced and mixed convection. The Brinkman model is used to simulate the momentum transfer in the porous duct.
Shyam Lal Yadav, Ashok Kumar Singh
openaire +2 more sources