Results 81 to 90 of about 314,940 (287)

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Exergy Analysis of a Domestic Refrigerator

open access: yesJournal of Engineering, 2018
An energy and exergy thermodynamic analysis using EES program was done for a domestic refrigerator working with R-134a using vapor compression refrigeration cycle. The analysis deals with the system component, i.e.
Loauy Abd Al-Azez Mahdi   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Entropy generation in a mixed convection Poiseulle flow of molybdenum disulphide Jeffrey nanofluid

open access: yesResults in Physics, 2018
Entropy analysis in a mixed convection Poiseulle flow of a Molybdenum Disulphide Jeffrey Nanofluid (MDJN) is presented. Mixed convection is caused due to buoyancy force and external pressure gradient.
Aaiza Gul   +2 more
doaj   +1 more source

Investigation to define the propagation characteristics of a finite amplitude acoustic pressure wave [PDF]

open access: yes
A theoretical analysis of the propagation characteristics of a finite amplitude pressure wave is presented. The analysis attempts to study the contribution of entropy-producing regions to the mechanism of aerodynamic noise generation.
Cottrell, J. W., Peter, A. C.
core   +1 more source

Utilizing RNA-Seq Data for Cancer Network Inference

open access: yes, 2012
An important challenge in cancer systems biology is to uncover the complex network of interactions between genes (tumor suppressor genes and oncogenes) implicated in cancer. Next generation sequencing provides unparalleled ability to probe the expression
Atwal, Gurinder S.   +2 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Shape Effect of Nanosize Particles on Magnetohydrodynamic Nanofluid Flow and Heat Transfer over a Stretching Sheet with Entropy Generation

open access: yesEntropy, 2020
Magnetohydrodynamic nanofluid technologies are emerging in several areas including pharmacology, medicine and lubrication (smart tribology). The present study discusses the heat transfer and entropy generation of magnetohydrodynamic (MHD) Ag-water ...
Umair Rashid   +3 more
doaj   +1 more source

Metastable Evolutionary Dynamics: Crossing Fitness Barriers or Escaping via Neutral Paths?

open access: yes, 1999
We analytically study the dynamics of evolving populations that exhibit metastability on the level of phenotype or fitness. In constant selective environments, such metastable behavior is caused by two qualitatively different mechanisms. One the one hand,
Crutchfield, James P.   +1 more
core   +1 more source

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