Results 81 to 90 of about 25,153,568 (292)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Entropy Generation Analysis of Buoyancy Effect on Hydromagnetic Poiseuille Flow with Internal Heat Generation [PDF]

, 2017
This paper presents the entropy generation analysis of buoyancy effect with internal heat generation on a viscous incompressible non-Newtonian hydromagnetic Poiseuille flow through vertical isothermal walls.
Olasumbo O. Agboola, Ogbu F. Imaga, Abiodun A. Opanuga, Hilary I. Okagbue   +3 more
core   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Effects of Multi-objective Optimization of the First-stage Impeller on the Energy Loss Characteristics of a Multistage Molten Salt Pump [PDF]

Journal of Applied Fluid Mechanics
To mitigate the prohibitive cost of simultaneously modifying all stages in multistage molten salt pumps used in concentrating solar power plants, address the substantial degradation of hydraulic performance under off-design operating conditions, and ...
Q. Chen, X. Yongkang, L. Shilin, Q. Zhipeng, W. Xiaohui   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Methods to Calculate Entropy Generation [PDF]

Entropy generation, formulated by combining the first and second laws of thermodynamics with an appropriate thermodynamic potential, emerges as the difference between a phenomenological entropy function and a reversible entropy function.
Michael D. Bryant, Osara, Jude A.; id_orcid, Bryant, Michael D., Jude A. Osara   +3 more
core   +1 more source

Exergy Analysis of a Domestic Refrigerator

Journal of Engineering, 2018
An energy and exergy thermodynamic analysis using EES program was done for a domestic refrigerator working with R-134a using vapor compression refrigeration cycle. The analysis deals with the system component, i.e.
Loauy Abd Al-Azez Mahdi, Wahid S. Mohammad, Samir Akram Mahmood   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Entropy generation in a mixed convection Poiseulle flow of molybdenum disulphide Jeffrey nanofluid

Results in Physics, 2018
Entropy analysis in a mixed convection Poiseulle flow of a Molybdenum Disulphide Jeffrey Nanofluid (MDJN) is presented. Mixed convection is caused due to buoyancy force and external pressure gradient.
Aaiza Gul, Ilyas Khan, Stanislav S. Makhanov   +2 more
doaj   +1 more source