Results 121 to 130 of about 125,230 (316)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Generalized Distance-Based Entropy and Dimension Root Entropy for Simplified Neutrosophic Sets

open access: yesEntropy, 2018
In order to quantify the fuzziness in the simplified neutrosophic setting, this paper proposes a generalized distance-based entropy measure and a dimension root entropy measure of simplified neutrosophic sets (NSs) (containing interval-valued and single ...
Wen-Hua Cui, Jun Ye
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Decomposition of Gini and the generalized entropy inequality measures [PDF]

open access: yes
In this article we provide an overview of the Gini decomposition and the generalized entropy inequality measures, a free access to their computation, an application on French wages, and a different way than Dagum to demonstrate that the Gini index is a ...
Michel Terraza   +2 more
core  

Minimal Entropy and Entropic Risk Measures: A Unified Framework via Relative Entropy

open access: yesRisks
We introduce a new coherent risk measure, the minimal-entropy risk measure, which is built on the minimal-entropy σ-martingale measure—a concept inspired by the well-known minimal-entropy martingale measure used in option pricing.
Moritz Sohns
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Learning Entropy: Multiscale Measure for Incremental Learning

open access: yesEntropy, 2013
First, this paper recalls a recently introduced method of adaptive monitoring of dynamical systems and presents the most recent extension with a multiscale-enhanced approach.
Ivo Bukovsky
doaj   +1 more source

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