Results 51 to 60 of about 42,764 (288)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang   +6 more
wiley   +1 more source

Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays

open access: yesAdvanced Science, EarlyView.
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen   +13 more
wiley   +1 more source

Melanotic neuroectodermal tumor of infancy: Does enucleation alone suffice?

open access: yesJournal of Indian Association of Pediatric Surgeons, 2021
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare melanin-containing mesenchymal tumor of neural crest origin. We present a case of MNTI in a 1-year-old girl. It was managed successfully with conservative excision (enucleation).
M M Zameer   +3 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

open access: yesAdvanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong   +24 more
wiley   +1 more source

Predictors of Enucleation and Morcellation Time During Holmium Laser Enucleation of the Prostate.

open access: yes, 2015
Objective To examine predictors of enucleation and morcellation times within a large cohort of men undergoing holmium laser enucleation of the prostate (HoLEP) for benign prostatic hypertrophy.
El Tayeb, Marawan   +6 more
core   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

open access: yesAdvanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao   +10 more
wiley   +1 more source

Minimally Invasive Thulium Laser Enucleation of the Prostate

open access: yesJournal of Urological Surgery
The goal of Minimal Invasive Laser Enucleation of Prostate (MiLEP) surgery is to reduce complication rates and risk of urethral trauma, while providing similar success rates by using smaller caliber instruments. Enucleation was performed with 22 Ch outer
Ahmet Furkan Özsoy   +1 more
doaj   +1 more source

Orbital relapse of retinoblastoma in patients with high-risk histopathology features

open access: yesTherapeutic Advances in Ophthalmology, 2019
Aim: To describe the clinical picture of orbital relapse of retinoblastoma following uncomplicated enucleation. Methods: Case series of two patients with group E retinoblastoma with high-risk features on histopathology, namely, post-laminar optic nerve ...
Maria Vittoria Cicinelli, Swathi Kaliki
doaj   +1 more source

Surgical Treatment for Esophageal Leiomyoma: 13 Years of Experience in a High-Volume Tertiary Hospital

open access: yesFrontiers in Oncology, 2022
BackgroundEsophageal leiomyoma is the most common benign tumor in the esophagus. Thoracotomy and thoracoscopy are both elective for esophageal leiomyoma enucleation.
Gu-Ha A-Lai   +3 more
doaj   +1 more source

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