Results 11 to 20 of about 39,645 (195)

Detecting early memory changes in preclinical Alzheimer's disease using TabCAT Favorites Test: data from the European Prevention of Alzheimer's Dementia cohort [PDF]

Alzheimers Dement
Abstract Background Sensitive memory paradigms are needed to detect subtle memory changes associated with early Alzheimer's disease (AD) pathology in individuals without established clinical symptomatology. We explored cross‐sectional associations between performance on a brief computerized episodic memory test with AD cerebrospinal fluid (CSF ...
Brugulat‐Serrat A, Tsoy E, Sánchez‐Benavides G, Milà‐Alomà M, Grau‐Rivera O, Gaynor L, Gispert J, Kramer J, Possin K.   +8 more
europepmc   +2 more sources

Late motherhood linked to accelerated memory decline in amyloid‐positive cognitively unimpaired women [PDF]

Alzheimers Dement
Abstract Background Both nulliparity and multiparity have been linked to an increased risk of dementia. However, evidence is inconclusive and requires further study. To further investigate the link between pregnancy history and cognition, we explored the link between age at first childbirth and cognitive change in cognitively unimpaired (CU) women and ...
Brugulat‐Serrat A, Gallay C, Sánchez‐Benavides G, López‐Martos D, Fernández‐Arcos A, Zetterberg H, Blennow K, Suárez‐Calvet M, Grau‐Rivera O, Gispert J, Sundermann E.   +10 more
europepmc   +2 more sources

Association of graph network properties with Alzheimer's pathological hallmarks early in the disease continuum [PDF]

Alzheimers Dement
Abstract Background Altered resting‐state functional connectivity (RSFC) has been reported in early Alzheimer's disease (AD). Graph metrics derived from RSFC networks provide valuable insights into brain organization. However, their potential in characterizing early network dysfunction and their relationship with AD biomarkers and cognitive performance
Lizarraga A, Kassinopoulos M, González‐de‐Echávarri J, Huguet J, Sánchez‐Benavides G, Grau‐Rivera O, Suarez‐Calvet M, Milà‐Alomà M, Blennow K, Zetterberg H, Kollmorgen G, Quijano‐Rubio C, Gispert J, Salvadó G, Cacciaglia R.   +14 more
europepmc   +2 more sources

Estrategia y plan de acción mundiales sobre el envejecimiento y la salud, 2016-2020 [PDF]

, 2016
La 69ª Asamblea Mundial de la Salud, convocada por la OMS aprobó la “Estrategia y plan de acción mundiales sobre el envejecimiento y la salud 2016-2020”, cuyos objetivos estratégicos son:Compromiso para adoptar medidas sobre el envejecimiento saludable ...
Abellán García, Antonio, Pérez Díaz, Julio   +1 more
core   +1 more source

Ancianos en la investigación de medicamentos

Revista Iberoamericana de Bioética, 2020
En las últimas décadas se viene produciendo un envejecimiento de la población que es foco de atención de instituciones de ámbito mundial con objeto de promover un envejecimiento saludable.
Olga Martínez Casares, Reyes Boceta Muñoz, Marta Albert Márquez   +2 more
doaj   +1 more source

Detecting Amyloid–β Pathology in Subjective Cognitive Decline using novel CSF and plasma biomarkers [PDF]

Alzheimers Dement
Abstract Background Cerebrospinal fluid (CSF) and blood‐based biomarkers are essential tools for detecting individuals with cognitive complaints and at‐risk of Alzheimer's disease (AD). However, their utility in detecting underlying AD pathology in subjective cognitive decline (SCD) remains to be fully established, and direct comparisons between ...
Contador J, Pozzi F, Sánchez‐Benavides G, Fernández‐Arcos A, Minguillón C, Fauria K, Escalante A, Ortiz‐Romero P, Quijano‐Rubio C, Kollmorgen G, Bastard N, Nadal A, Gonzalez‐Ortiz F, Rodriguez J, Montoliu‐Gaya L, Vanmechelen E, Torres‐Torronteras J, Ashton N, Zetterberg H, Blennow K, Gispert J, Molinuevo J, del Campo M, Grau‐Rivera O, Suárez‐Calvet M.   +24 more
europepmc   +2 more sources

Plasma biomarkers predict long‐term longitudinal cognitive decline in individuals at‐risk for Alzheimer's disease: differences across demographic groups [PDF]

Alzheimers Dement
Abstract Background Plasma biomarkers are promising tools for detecting Ab pathology in cognitively unimpaired (CU) individuals. However, their association with cognitive trajectories and how this associations vary across demographic subgroups remain unclear.
Escalante A, Ortiz‐Romero P, Torres‐Torronteras J, Jiménez‐Moyano E, Blasco‐Forniés H, Diego‐Osaba M, Anastasi F, Triana‐Baltzer G, Kolb H, Vanmechelen E, López‐Martos D, Sánchez‐Benavides G, Grau‐Rivera O, Minguillon C, Fauria K, Blennow K, Zetterberg H, Ashton N, Vilor‐Tejedor N, del Campo M, Suárez‐Calvet M.   +20 more
europepmc   +2 more sources

Envejecimiento saludable

, 2018
Para muchas generaciones ha sido un sueño el deseo de poder vivir más años. Hoy día, muchas personas han visto cumplido este anhelo ya que ha habido un avance en la ciencia y en la medicina, paralelo a un desarrollo social tanto a través del progreso de polí­ ticas sociales como de los servicios prestados por el Sistema Nacional de Salud, que han
Comino Sanz, Inés María, Sanchez Pablo, Clara   +1 more
openaire   +3 more sources

Factores de riesgo de fractura incidente en pacientes con cáncer de mama tratadas con inhibidores de la aromatasa: cohorte B-ABLE

Revista de Osteoporosis y Metabolismo Mineral, 2020
Objetivo: Los inhibidores de la aromatasa (IA) se han asociado con una pérdida de masa ósea acelerada y un mayor riesgo de fracturas osteoporóticas.
García-Giralt N, Pineda-Moncusí M, Ovejero D, Aymar I, Soldado-Folgado J, Campodarve I, Rodríguez-Morera J, Nogués X   +7 more
doaj   +1 more source

Recent Approaches to Determine Static and Dynamic Redox State-Related Parameters

Antioxidants, 2022
Oxidative stress refers to an imbalance between oxidant and antioxidant molecules, which is usually associated with oxidative damage to biomolecules and mitochondrial malfunction. Redox state-related parameters include (1) the direct measurement of ROS, (
Cristina Mas-Bargues, Esther García-Domínguez, Consuelo Borrás   +2 more
doaj   +1 more source