Results 41 to 50 of about 1,784 (173)

Supervised Exercise Intervention Restores Physical Activity and MultiOMIC‐Derived Frailty Biomarkers in Older Adults

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The molecular mechanisms underlying frailty are under intense investigation. Independent observational studies revealed various biological processes and biomarkers differentially expressed in frail individuals and after interventions.
Diego Marcos‐Perez, Sara Cruces‐Salguero, Morelva Saeteros, Rafael Garcia Molina, Ruben Alcantud‐Córcoles, Cristina Alonso‐Bouzon, Itziar Vergara, Sergio J. Sanabria, Leocadio Rodriguez‐Mañas, Pedro Abizanda, Ander Matheu   +10 more
wiley   +1 more source

Digital speech‐based markers to advance prognosis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Validated prognostic tools are essential to advance drug development and clinical care in Alzheimer's disease, particularly as the field shifts toward the prevention of cognitive decline. While progress has been made in developing blood‐based biomarkers for the early detection of amyloid pathology, amyloid positivity alone does not reliably ...
Melissa Lee, Stephan Meylan, Eli Shobin, the SpeechDx Consortium, Laura Nisenbaum, Aishwarya Sukumar, Lampros Kourtis   +6 more
wiley   +1 more source

Small extracellular vesicles from senescent stem cells trigger adaptive mechanisms in young stem cells by increasing antioxidant enzyme expression

Redox Biology, 2023
Extracellular vesicles' biogenesis, shedding, and uptake are redox-sensitive. Indeed, oxidative stress conditions influence extracellular vesicles’ release and content, which can modulate the redox status of the receiving cells.
Cristina Mas-Bargues, Jorge Sanz-Ros, Nekane Romero-García, Javier Huete-Acevedo, Mar Dromant, Consuelo Borrás   +5 more
doaj   +1 more source

Physical Fitness and Cognitive Performance in Preschool Children: Cross‐Sectional and Longitudinal Associations From the ELFIT Trial

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 6, June 2026.
ABSTRACT Growing evidence shows that physical fitness and cognitive function might be interrelated, but evidence is mostly cross‐sectional and research in preschool children remains scarce. We aimed to analyze both cross‐sectional and longitudinal associations between fitness indicators and cognitive outcomes in preschoolers. In this secondary analysis
Carlos Martin‐Martinez, Pedro L. Valenzuela, Asier Mañas, Oscar Martinez‐de‐Quel   +3 more
wiley   +1 more source

Speech‐based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Early detection of Alzheimer's disease (AD) is critical for timely intervention as disease‐modifying treatments emerge. Speech‐based digital biomarkers offer scalable options for remotely capturing speech‐derived functional changes associated with early cognitive decline, but validation across real‐world populations remains ...
Alexandra König, Johannes Tröger, Elisa Mallick, Nicklas Linz, Craig Ritchie, Sarah Gregory, Matthew Hunter, Kay Johnson, Gonzalo Sánchez Benavides, Oriol Grau‐Rivera, Andreea Radoi, Claudia Porta‐Mas, Stefanie Köhler, Stefan Teipel, Oskar Hansson, Pontus Tideman, Anika Wuestefeld, Sebastian Palmqvist   +17 more
wiley   +1 more source

Comparative Analysis of Dietary Patterns in Children With Phenylketonuria Phenotypes and Controls: Implications for Nutritional Status

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Individuals with phenylketonuria (PKU), caused by different variants of the phenylalanine hydroxylase gene, need to restrict their intake of phenylalanine. This study evaluated dietary patterns and physical activity levels in children with different PKU phenotypes compared to healthy controls. Eighty‐two children were recruited (22 classic PKU
Dolores Garcia‐Arenas, Aida Ormazabal, Paula Isern, Blanca Barrau‐Martinez, Arnau Gonzalez‐Rodriguez, Alba Tor‐Roca, Rafael Llorach, Jaume Campistol‐Plana, Mireia Urpi‐Sarda, Consortium PKU.cat.   +9 more
wiley   +1 more source

Associations of 18F‐RO‐948 tau PET with fluid AD biomarkers, Centiloid, and cognition in early AD continuum

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION We examined neurofibrillary tangle (NFT) pathology using 18F‐RO‐948 tau positron emission tomography (PET) in cognitively unimpaired individuals and its associations with amyloid plaques, fluid biomarkers, and cognition in early preclinical Alzheimer's disease (AD).
Mahnaz Shekari, Armand González Escalante, Marta Milà‐Alomà, Carles Falcon, David López‐Martos, Gonzalo Sánchez‐Benavides, Anna Brugulat‐Serrat, Aida Niñerola‐Baizán, Nicholas J. Ashton, Thomas K. Karikari, Juan Lantero‐Rodriguez, Laia Montoliu‐Gaya, Anniina Snellman, Theresa A. Day, Jeffrey L. Dage, Paula Ortiz‐Romero, Matteo Tonietto, Edilio Borroni, Gregory Klein, Gwendlyn Kollmorgen, Margherita Carboni, Clara Quijano‐Rubio, Eugeen Vanmechelen, Carolina Minguillón, Karine Fauria, Andrés Perissinotti, José Luis Molinuevo, Henrik Zetterberg, Kaj Blennow, Oriol Grau‐Rivera, Marc Suárez‐Calvet, Juan Domingo Gispert, for the ALFA Study   +32 more
wiley   +1 more source

Effect of the Tumor Suppressor miR-320a on Viability and Functionality of Human Osteosarcoma Cell Lines Compared to Primary Osteoblasts

Applied Sciences, 2020
The miR-320a regulates a number of genes involved in various physiological processes. In particular, it has been reported as a tumor suppressor in several types of human cancers and involved in osteoporotic fracture and osteoblast function.
Laura De-Ugarte, Susanna Balcells, Robert Guerri-Fernandez, Daniel Grinberg, Adolfo Diez-Perez, Xavier Nogues, Natalia Garcia-Giralt   +6 more
doaj   +1 more source

Envejecimiento activo desde una perspectiva de género

Revista Iberoamericana de Bioética, 2022
El presente artículo analiza el envejecimiento activo de las mujeres mayores y la doble discriminación que sufren tanto por encontrarse en su etapa de envejecimiento, como por el hecho de ser mujeres. Existen grandes desigualdades entre hombres y mujeres
María Oliva Sirgo Álvarez
doaj   +1 more source

Comunicación, Envejecimiento y Salud

REVISTA CIENTÍFICA SIGNOS FÓNICOS, 2015
  Introducción: La Comunicación como eje trasversal de los programas de promoción de la salud permite generar acciones encaminadas al mejoramiento de la calidad de vida de las personas en todas sus dimensiones (salud, social, cultural, afectiva). Métodos: La sistematización de experiencias como metodología de investigación permite re-construir las ...
openaire   +1 more source