Results 61 to 70 of about 1,784 (173)

A Multidomain Lifestyle Intervention Is Associated With Improved Functional Trajectories and Favorable Changes in Epigenetic Aging Markers in Frail Older Adults: A Randomized Controlled Trial

Aging Cell, Volume 25, Issue 2, February 2026.
In frail older adults, a 6‐month lifestyle intervention slowed epigenetic aging and improved functional outcomes, suggesting lifestyle strategies may delay biological aging and disability progression. ABSTRACT Frailty emerges as the intermediate stage preceding disability, but there is a gap in molecular signatures for early detection of subclinical ...
Gloria Olaso‐Gonzalez, Fernando Millan‐Domingo, Luis Garcia‐Fernandez, Elisa Garcia‐Tercero, Monica Cebrian, Cristina Garcia‐Dominguez, Juan Antonio Carbonell, German Casabo‐Valles, Jose Luis Garcia‐Gimenez, Eva Tamayo‐Torres, Juan Gambini, Francisco Jose Tarazona‐Santabalbina, Jose Vina, Maria Carmen Gomez‐Cabrera   +13 more
wiley   +1 more source

Validation status of cognitive digital assessments by the FDA BEST framework and context of use in preclinical AD studies: A systematic review

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract Digital cognitive assessments have rapidly expanded in Alzheimer's disease (AD) research, offering a sensitive, scalable, and cost‐effective alternative to traditional neuropsychological tests. This systematic review examines the validation and utility of digital cognitive assessments in cognitively normal (CN) individuals and explores their ...
Clàudia Porta‐Mas, Oriol Grau‐Rivera, Juan Domingo Gispert, Gemma Salvadó Blasco, Gonzalo Sánchez‐Benavides   +4 more
wiley   +1 more source

Microglial reactivity attenuates ptau231‐related amyloid accumulation in preclinical Alzheimer’s disease [PDF]

Alzheimers Dement
Abstract Background Recent studies indicate that soluble tau phosphorylated at threonine 231 (p‐tau231) rises most prominently in the earliest preclinical stages of Alzheimer's disease (AD), preceding overt amyloid‐beta (Aβ) PET positivity. Elevated p‐tau231 levels may promote emerging Aβ deposition, but the biological mechanisms linking early tau ...
Pelkmans W, Shekari M, Escalante A, Kollmorgen G, Quijano‐Rubio C, Blennow K, Zetterberg H, Gispert J, Suárez‐Calvet M, Salvadó G.   +9 more
europepmc   +3 more sources

Envelhecimento saudável: uma revisão das pesquisas em Língua Inglesa

Movimento, 2006
"Envejecimiento saludable", con una perspectiva particular para explorar la relación entre salud y envejeciemento, es un paradigma teórico poderoso en la cultura e práctica de la geriatria y una fuerza dominante en las agendas de pesquisa, organizaciones
Paula J. Gardner
doaj  

Bases moleculares del envejecimiento. Un envejecimiento saludable

, 2022
Grado en ...
openaire   +1 more source

El papel de la extensión universitaria en el avance del envejecimiento saludable en América Latina

MedUNAB
Editorial ¿De qué manera una universidad demuestra realmente su impacto en la sociedad? Esta pregunta es cada vez más recurrente en los debates académicos en América Latina. ¿Cuál es el camino más pertinente y coherente?
Hendrik Adrián Baracaldo-Campo, Rafael Pizarro-Mena   +1 more
doaj   +1 more source

Artículo de revisión sobre la prevención del envejecimiento patológico con base en factores psíquicos protectores

Entretextos, 2020
La vejez —construcción social de la última etapa de la vida— y el envejecimiento —proceso gradual desarrollado a lo largo de la vida— (OEA, 2020) implican distintos cambios en diferentes aspectos de la persona; sin embargo, nunca se da de la misma manera
Estefany Jazmín López Ramos, Montserrat Uribe Rodríguez, Osiel Jafit Equihua Márquez   +2 more
doaj   +1 more source

New Diterpenes from

Natural Product Communications, 2014
Two new diterpenes,2-acetoxy-13-hydroxy-mulin-11-ene and 2-acetoxy-mulin-11, 13-diene, have been isolated from the aerial parts of Azorella spinosa and their structures determined by spectroscopic and conventional chemical methods.
Luis Astudillo, Margarita Gutiérrez, Luisa Quesada, Aurelio San-Martín, Luis Espinoza, Patricio Peñailillo   +5 more
doaj   +1 more source

Synergistic Effects of Plasma p‐tau217 and GFAP on Neurodegeneration and Cognitive Decline in Cognitively Unimpaired Individuals [PDF]

Alzheimers Dement
Abstract Background Plasma phosphorylated tau at threonine 217 (p‐tau217) is an accurate biomarker for Alzheimer's pathology. Emerging data suggest that plasma p‐tau217, especially when combined with Glial Fibrillary Acidic Protein (GFAP), predicts cognitive decline up to a decade before clinical onset. However, no studies have quantified its impact on
Cacciaglia R, Escalante A, Ortiz‐Romero P, Grau‐Rivera O, Sánchez‐Benavides G, Day T, Blennow K, Zetterberg H, Molinuevo J, Gispert J, Suárez‐Calvet M, Salvadó G.   +11 more
europepmc   +2 more sources

Autopercepción de Salud y Envejecimiento

Ciencia e Innovación en Salud, 2013
El aumento de la esperanza de vida ha producido en las últimas décadas un importante crecimiento de la población adulta mayor, estimándose que en el año 2050 casi un tercio de la población mundial estará compuesta por personas mayores de 65 años.
openaire   +2 more sources