Results 51 to 60 of about 101,226 (206)

Supervised Exercise Intervention Restores Physical Activity and MultiOMIC‐Derived Frailty Biomarkers in Older Adults

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The molecular mechanisms underlying frailty are under intense investigation. Independent observational studies revealed various biological processes and biomarkers differentially expressed in frail individuals and after interventions.
Diego Marcos‐Perez   +10 more
wiley   +1 more source

Digital speech‐based markers to advance prognosis in Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Validated prognostic tools are essential to advance drug development and clinical care in Alzheimer's disease, particularly as the field shifts toward the prevention of cognitive decline. While progress has been made in developing blood‐based biomarkers for the early detection of amyloid pathology, amyloid positivity alone does not reliably ...
Melissa Lee   +6 more
wiley   +1 more source

Small extracellular vesicles from senescent stem cells trigger adaptive mechanisms in young stem cells by increasing antioxidant enzyme expression

open access: yesRedox Biology, 2023
Extracellular vesicles' biogenesis, shedding, and uptake are redox-sensitive. Indeed, oxidative stress conditions influence extracellular vesicles’ release and content, which can modulate the redox status of the receiving cells.
Cristina Mas-Bargues   +5 more
doaj   +1 more source

Physical Fitness and Cognitive Performance in Preschool Children: Cross‐Sectional and Longitudinal Associations From the ELFIT Trial

open access: yesScandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 6, June 2026.
ABSTRACT Growing evidence shows that physical fitness and cognitive function might be interrelated, but evidence is mostly cross‐sectional and research in preschool children remains scarce. We aimed to analyze both cross‐sectional and longitudinal associations between fitness indicators and cognitive outcomes in preschoolers. In this secondary analysis
Carlos Martin‐Martinez   +3 more
wiley   +1 more source

Speech‐based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts

open access: yesAlzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Early detection of Alzheimer's disease (AD) is critical for timely intervention as disease‐modifying treatments emerge. Speech‐based digital biomarkers offer scalable options for remotely capturing speech‐derived functional changes associated with early cognitive decline, but validation across real‐world populations remains ...
Alexandra König   +17 more
wiley   +1 more source

Comparative Analysis of Dietary Patterns in Children With Phenylketonuria Phenotypes and Controls: Implications for Nutritional Status

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Individuals with phenylketonuria (PKU), caused by different variants of the phenylalanine hydroxylase gene, need to restrict their intake of phenylalanine. This study evaluated dietary patterns and physical activity levels in children with different PKU phenotypes compared to healthy controls. Eighty‐two children were recruited (22 classic PKU
Dolores Garcia‐Arenas   +9 more
wiley   +1 more source

Associations of 18F‐RO‐948 tau PET with fluid AD biomarkers, Centiloid, and cognition in early AD continuum

open access: yesAlzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION We examined neurofibrillary tangle (NFT) pathology using 18F‐RO‐948 tau positron emission tomography (PET) in cognitively unimpaired individuals and its associations with amyloid plaques, fluid biomarkers, and cognition in early preclinical Alzheimer's disease (AD).
Mahnaz Shekari   +32 more
wiley   +1 more source

COVID-19 y Envejecimiento Saludable

open access: yes, 2021
Jornadas Académicas de Salud 2021Las Jornadas Académicas en Salud 2021 tienen como propósito promover la actualización de los profesionales de la salud de diversas especialidades, enfatizando la atención interprofesional centrada en el ...
Dra. Alba Zuzunaga
core  

Effect of the Tumor Suppressor miR-320a on Viability and Functionality of Human Osteosarcoma Cell Lines Compared to Primary Osteoblasts

open access: yesApplied Sciences, 2020
The miR-320a regulates a number of genes involved in various physiological processes. In particular, it has been reported as a tumor suppressor in several types of human cancers and involved in osteoporotic fracture and osteoblast function.
Laura De-Ugarte   +6 more
doaj   +1 more source

The landscape of dementia research, diagnosis, treatment, and care in Latin America

open access: yesAlzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Latin America is undergoing rapid population aging alongside a rising burden of dementia. While the region holds substantial potential for dementia risk reduction, challenges remain, such as delayed diagnoses, limited access to specialized care and biomarker testing, persistent stigma, and deep‐rooted structural inequities.
Claudia K. Suemoto   +41 more
wiley   +1 more source

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