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Associations of 18F‐RO‐948 tau PET with fluid AD biomarkers, Centiloid, and cognition in early AD continuum

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION We examined neurofibrillary tangle (NFT) pathology using 18F‐RO‐948 tau positron emission tomography (PET) in cognitively unimpaired individuals and its associations with amyloid plaques, fluid biomarkers, and cognition in early preclinical Alzheimer's disease (AD).
Mahnaz Shekari +32 more
wiley +1 more source

The landscape of dementia research, diagnosis, treatment, and care in Latin America

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Latin America is undergoing rapid population aging alongside a rising burden of dementia. While the region holds substantial potential for dementia risk reduction, challenges remain, such as delayed diagnoses, limited access to specialized care and biomarker testing, persistent stigma, and deep‐rooted structural inequities.
Claudia K. Suemoto +41 more
wiley +1 more source

N‐Acetylglucosamine Selectively Attenuates Neuroinflammation in a Mouse Model of Mitochondrial Dysfunction

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim Mitochondrial dysfunction plays a central role in multiple neurodegenerative diseases, yet the temporal sequence of cellular events underlying neurodegeneration remains poorly defined. This study aimed to characterize the progression of neurodegeneration in a mouse model of fatal mitochondrial encephalopathy and to evaluate the therapeutic
Laura Jiménez‐Sánchez +12 more
wiley +1 more source

Cognición en adultos mayores con envejecimiento saludable: Análisis de la Encuesta Nacional de Salud y Envejecimiento en México 2012-2015 [PDF]

, 2023
En nuestro estudio se pudieron analizar las bases de datos de la Encuesta Nacional de Salud y Envejecimiento en México (ENASEM) durante los periodos del 2012 y 2015.
Garza Guerra, José Daniel
core

Efficacy of a Multicomponent Intervention for Frailty or Physical Function in Prefrail or Frail Older Adults: FRAILMERIT Multicenter Clinical Trial

Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 658-668, March 2026.
Clinical management of the older adult. ABSTRACT Objectives Frailty is a common condition in community‐dwelling older adults with high health and socioeconomic implications. However, primary care‐led randomized trials have been scarcely tested. Design Multicenter cluster randomized clinical trial.
Adriana Abizanda Saro +86 more
wiley +1 more source

Differential contribution of T‐type voltage‐gated calcium channels to vascular reactivity in the aorta and renal artery of healthy rabbits

Experimental Physiology, Volume 111, Issue 3, Page 1498-1512, 1 March 2026.
Abstract figure T‐type VGCCs contribute to the contraction of the rabbit aorta and modulate both contraction and vasodilation in the rabbit renal artery. α1, alpha 1 adrenergic receptor; ATR, angiotensin II receptor; Ang II, angiotensin II; CaM, calmodulin; Cav3, T‐type voltage‐gated Ca2⁺ channels; cGMP, cyclic guanidine monophosphate; EC, endothelial ...
Andrea Suarez +6 more
wiley +1 more source

COVID-19 y Envejecimiento Saludable

, 2021
Jornadas Académicas de Salud 2021Las Jornadas Académicas en Salud 2021 tienen como propósito promover la actualización de los profesionales de la salud de diversas especialidades, enfatizando la atención interprofesional centrada en el ...
Dra. Alba Zuzunaga
core

Detecting early memory changes in preclinical Alzheimer's disease using TabCAT favorites test: Data from the European Prevention of Alzheimer's Disease (EPAD) cohort

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sensitive memory paradigms may allow the detection of subtle memory changes associated with early Alzheimer's pathology in individuals without established clinical symptomatology. METHODS We explored the cross‐sectional association between performance on Tablet‐based Cognitive Assessment Tool (TabCAT) Favorites, a brief ...
Anna Brugulat‐Serrat +9 more
wiley +1 more source

Relationship between locus coeruleus and slow‐wave sleep in aging and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep disruption, particularly loss of slow‐wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus coeruleus (LC) integrity relates to SWS across the AD continuum and whether sex and perivascular spaces (PVSs) modify these associations.
Neus Falgàs +20 more
wiley +1 more source

A Multidomain Lifestyle Intervention Is Associated With Improved Functional Trajectories and Favorable Changes in Epigenetic Aging Markers in Frail Older Adults: A Randomized Controlled Trial

Aging Cell, Volume 25, Issue 2, February 2026.
In frail older adults, a 6‐month lifestyle intervention slowed epigenetic aging and improved functional outcomes, suggesting lifestyle strategies may delay biological aging and disability progression. ABSTRACT Frailty emerges as the intermediate stage preceding disability, but there is a gap in molecular signatures for early detection of subclinical ...
Gloria Olaso‐Gonzalez +13 more
wiley +1 more source

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