Fenotipo de envejecimiento saludable de personas mayores en Manizales [PDF]
Biomedica, 2020 Introduction: The healthy aging phenotype is present in those individuals that age with low morbidity, no functional or cognitive deterioration, and retain an acceptable level of wellness and social participation.Objective: To establish the frequency of ...
Giraldo, Andrés Fernando +2 more
core +2 more sources
Late motherhood linked to accelerated memory decline in amyloid‐positive cognitively unimpaired women [PDF]
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Both nulliparity and multiparity have been linked to an increased risk of dementia. However, evidence is inconclusive and requires further study. To further investigate the link between pregnancy history and cognition, we explored the link between age at first childbirth and cognitive change in cognitively unimpaired (CU) women and ...
Anna Brugulat‐Serrat +11 more
wiley +2 more sources
Association of graph network properties with Alzheimer's pathological hallmarks early in the disease continuum [PDF]
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Altered resting‐state functional connectivity (RSFC) has been reported in early Alzheimer's disease (AD). Graph metrics derived from RSFC networks provide valuable insights into brain organization. However, their potential in characterizing early network dysfunction and their relationship with AD biomarkers and cognitive performance
Aldana Lizarraga +14 more
wiley +2 more sources
Microglial reactivity attenuates ptau231‐related amyloid accumulation in preclinical Alzheimer's disease [PDF]
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Recent studies indicate that soluble tau phosphorylated at threonine 231 (p‐tau231) rises most prominently in the earliest preclinical stages of Alzheimer's disease (AD), preceding overt amyloid‐beta (Aβ) PET positivity. Elevated p‐tau231 levels may promote emerging Aβ deposition, but the biological mechanisms linking early tau ...
Wiesje Pelkmans +9 more
wiley +3 more sources
Predicting cognitive trajectories in asymptomatic individuals at‐risk of AD: insights from a multi‐platform plasma proteomics study [PDF]
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Plasma biomarkers enabling early detection of Alzheimer's disease (AD) biological hallmarks are now available. Yet, predicting cognitive decline in at‐risk individuals remains challenging due to the high variability of cognitive outcomes and lack of reliable prognostic markers.
Federica Anastasi +10 more
wiley +2 more sources
Synergistic Effects of Plasma p‐tau217 and GFAP on Neurodegeneration and Cognitive Decline in Cognitively Unimpaired Individuals [PDF]
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Plasma phosphorylated tau at threonine 217 (p‐tau217) is an accurate biomarker for Alzheimer's pathology. Emerging data suggest that plasma p‐tau217, especially when combined with Glial Fibrillary Acidic Protein (GFAP), predicts cognitive decline up to a decade before clinical onset. However, no studies have quantified its impact on
Raffaele Cacciaglia +11 more
wiley +2 more sources
Envejecimiento Activo y Saludable [PDF]
, 2022 El principal objetivo de este estudio es conocer cómo el ejercicio físico, el funcionamiento cognitivo, la satisfacción vital o la nutrición repercuten en la salud de las personas mayores. El marco de referencia surge del estudio del envejecimiento saludable y activo, como consecuencia del aumento en el número de personas mayores y la
Álvarez González, Elena
openaire +2 more sources
Exploring the impact of childbirth on the association between white matter hyperintensity load and cognitive changes in post‐menopausal women at risk of Alzheimer's Disease [PDF]
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Cerebrovascular diseases impact cognition in middle‐aged individuals. Hormonal changes caused by childbirth impact the cerebrovascular system, yet little is known about its influence on cognition. We examined the influence of associations between number of childbirths and white matter hyperintensities (WMH) on cognitive change, in ...
Clara Gallay +10 more
wiley +2 more sources
Cerebral glucose metabolism and regional homogeneity as predictors of amyloid burden changes in preclinical AD [PDF]
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Regional homogeneity (ReHo) is a widely used measure in resting‐state functional magnetic resonance imaging (rs‐fMRI) for assessing the coherence of blood oxygen level‐dependent (BOLD) fMRI timeseries among contiguous brain regions.
Michalis Kassinopoulos +14 more
wiley +2 more sources
Bases moleculares del envejecimiento. Un envejecimiento saludable [PDF]
, 2022 Grado en ...
Muñoz Bueno, Javier
openaire +2 more sources